Marina Cuchel, MD, PhD

Research Associate Professor of Medicine (Translational Medicine and Human Genetics)

Department: Medicine

Contact information

Institute for Translational Medicine and Therapeutics
9017 Maloney Building
3600 Spruce Street
Philadelphia, PA 19104

Office: (215) 662-7188
Fax: (215) 615-6520

Links
Primary Work Website
Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine

Education:
MD (Medicine)
Universita' degli Studi di Milano, Milan, Italy, 1987.
Specialist (Geriatric Medicine)
Universita' degli Studi di Milano, Milan, Italy, 1991.
PhD (Pathophysiology of Aging)
Universita' degli Studi di Milano, Milan, Italy, 1998.
MS (Translational Research)
University of Pennsylvania School of Medicine, 2008.

Post-Graduate Training
Resident, Center for the Study and Treatment of Atherosclerosis, Gerontology and Geriatric Medicine, Universita' degli Studi di Milano, Milan, Italy, 1987-1992.
Research Associate, Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging, Tufts University, Boston, MA, 1992-1993.
Graduate Student, Gerontology and Geriatrics Medicine, Department of Internal Medicine, Universita' degli Studi di Milano, 1993-1998.
Clinical Research Assistant, Pathological Biochemistry, Glasgow Royal Infirmary University NHS Trust, Glasgow, UK, 1995-2000.
Postdoctoral Fellow, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, 2001-2002.

Permanent link

Description of Research Expertise

Dr. Cuchel is interested in the study of mechanisms regulating the metabolism of lipid and lipoproteins, using two parallel approaches: animal models and well-defined human monogenic disorders. She is also interested in early phase development of novel therapeutic strategies for the treatment of rare genetic disorders of lipid metabolism and for the enhancement of reverse cholesterol transport.

Selected Publications

Stankov S, Cuchel M.: Gene editing for dyslipidemias: New tools to "cut" lipids. Atherosclerosis Jan 2023.

Vitali C, Rader DJ, Cuchel M.: Novel therapeutic opportunities for familial lecithin:cholesterol acyltransferase deficiency: promises and challenges. Curr Opin Lipidol Dec 2022.

Tromp TR, Cuchel M.: New algorithms for treating homozygous familial hypercholesterolemia. Curr Opin Lipidol 33: 326-335, Dec 2022.

Bajaj A, Cuchel M.: From supravalvular to valvular aortic stenosis: are statins contributing to the phenotypic shift in homozygous familial hypercholesterolaemia? Eur Heart J 43: 3240-3242, Sep 2022.

Bajaj A, Cuchel M.: Advancements in the Treatment of Homozygous Familial Hypercholesterolemia. J Atheroscler Thromb Apr 2022.

Vitali C, Bajaj A, Nguyen C, Schnall J, Chen J, Stylianou K, Rader DJ, Cuchel M.: A systematic review of the natural history and biomarkers of primary Lecithin:Cholesterol Acyltransferase (LCAT) deficiency. J Lipid Res Jan 2022.

Tromp TR, Hartgers ML, Hovingh GK, Vallejo-Vaz AJ, Ray KK, Soran H, Freiberger T, Bertolini S, Harada-Shiba M, Blom DJ, Raal FJ, Cuchel M; Homozygous Familial Hypercholesterolaemia International Clinical Collaborators.: Worldwide experience of homozygous familial hypercholesterolaemia: retrospective cohort study. Lancet 399: 719-728, Jan 2022.

Zanotti I, Potì F, Cuchel M.: HDL and reverse cholesterol transport in humans and animals: Lessons from pre-clinical models and clinical studies. Biochim Biophys Acta Mol Cell Biol Lipids 2022.

Cuchel M, McGowan MP.: Familial hypercholesterolaemia: too many lost opportunities. Lancet 398: 1667-1668, Nov 2021.

Hancock-Cerutti W, Millar JS, Valentini S, Liu J, Billheimer JT, Rader DJ, Cuchel M.: Assessing HDL Metabolism in Subjects with Elevated Levels of HDL Cholesterol and Coronary Artery Disease. Molecules 26: 6862, Nov 2021.