Lorraine E Levitt Katz, MD

Professor of Pediatrics (Endocrinology and Diabetes) at the Children's Hospital of Philadelphia

Department: Pediatrics

Contact information

The Children's Hospital of Philadelphia
34th & Civic Center Blvd.
Philadelphia, PA 19104-4399

Office: 2155903174
Fax: 2155903053

Links
The longest-running study of type 2 diabetes in young people, Longitudinal Outcomes in Youth with Type 2 Diabetes—The TODAY2 Study, is winding down. Results to date show that youth-onset type 2 diabetes is more aggressive than adult-onset disease.
Penn News Today June 2013
Medical mystery author
Research Suggests Youth-onset Type 2 Diabetes More Severe than Adult-onset Disease
ITMAT
T2D in Teens: More Severe Complications. Investigator Dr Lorraine Levitt Katz provides an update of the data presented at ADA 2019.
Session Reports Latest from TODAY2 Research
Weight loss threshold for improving insulin sensitivity

Education:
B.A. (Biology)
Barnard College/Columbia University, 1984.
M.D.
University of Connecticut School of Medicine, 1989.

Post-Graduate Training
Resident in Pediatrics, Babies Hospital/Columbia Presbyterian Medical Center, 1989-1992.
Clinical Fellow in Pediatric Endocrinology, The Children's Hospital of Philadelphia, 1992-1993.
Research Fellow in Pediatric Endocrinology, The Children's Hospital of Philadelphia, 1993-1996.
CHOP Physician Leadership Program, CHOP, 2016-2017.
ITMAT Research Mentor Training, University of Pennsylvania School of Medicine, 2018-2018.
Patient Safety Certificate, Institute for Healthcare Improvement (IHI) , 2019-2019.
Quality Improvement Certificate, Institute for Healthcare Improvement (IHI), 2019-2019.

Permanent link

Description of Research Expertise

insulin-like growth factor axis
insulin resistance in children
type 2 diabetes in children

Description of Clinical Expertise

pediatric diabetes
pediatric carbohydrate metabolism
pediatric endocrinology

Description of Other Expertise

resident education
patient-oriented research

Selected Publications

Barbara Braffett, Fida Bacha; Laure El ghormli; Amy Shah; Santica Marcovina; Lorraine Levitt Katz; Steven Willi; Sonia Caprio; Ruban Dhaliwal; Samuel Gidding : Candidate Biomarkers as Predictors of Future Kidney Disease and Cardiovascular Dysfunction in Adolescents with Type 2 Diabetes Corresponding. Diabetes Research and Clinical Practice 199: 110671, May 2023.

Koren, Dorit; Knutson, Kristen L.; Burke, Brian K.; Drews, Kimberly; Bacha, Fida; Katz, Lorraine, Marcus, Marsha; McKay, Siripoom; Nadeau, Kristen; Mokhlesi, Babak : The Association of Self-Reported Sleep andCircadian Measures with Glycemic Control and Diabetes Complications among Young Adults with Type 2 Diabetes: Results from the TODAY2 Study. Diabetes research and Clinical Practice, submitted 2023.

Lynne L Levitsky, Kimberly L Drews, Rose A. Glubitosi-Klug, Lori Laffel, Lorraine E Levitt Katz, Mihai Mittelu, William Tamborlane, Jeanie B. Tryggestad, Ruth S. Weinstock, for the TODAY Study Group: The Obesity Paradox: Retinopathy, Obesity, and Circulating Risk Markers in Youth with Type 2 Diabetes in the TODAY Study. Journal of Diabetes and its Complications 36(11): 108259, November 2022 Notes: doi: 10.1016/j.jdiacomp.2022.108259. Epub 2022 Jul 19.

Sheela N. Magge, MD, MSCEa , *Risa M. Wolf, MDa , Laura Pyle, PhDb 4 , Elizabeth A. Brown, MPHa , Valeria C. Benavides, MD, MPHc , Monica E. Bianco, MDd , Lily C. Chao, MDe 5 , Anna Cymbaluk, MDf , Pinar Gumus Balikcioglu, MDg , Kelsee Halpin, MD, MPHh 6 , Daniel S. Hsia, MDi , Lina Huerta-Saenz, MDj , Jane J. Kim, MDk , Seema Kumar, MDl 7 , Lorraine E Levitt Katz, MDm, Brynn E. Marks, MD, MSHPEdn , Anna Neyman, MDo , Katie L. O’Sullivan, MDp 8 , Sabitha Sasidharan Pillai, MDq , Amy S. Shah, MD, MSr , Ashley H. Shoemaker, MD, MSCIs 9 , Juwairriyyah A. W. Siddiqui, MDt , Shylaja Srinivasan, MDu , Inas H Thomas, MDv , Jeanie B. Tryggestad, MDw 10 , Maha F. Yousif, MDx , Megan M. Kelsey, MD, MSb 11 on behalf of the COVID-19 and Type 2 12 Diabetes Consortium^: The COVID-19 pandemic is associated with a substantial rise in frequency and severity of presentation of youth-onset type 2 diabetes. Journal of Pediatrics 251(Suppl), August 2022.

Mary Ellen Vajravelu*, Joseph M. Kindler, Babette S. Zemel, Abbas Jawad, Dorit Koren,Preneet Brar, Lee J. Brooks, Jessica Reiner and Lorraine E. Levitt Katz: Visceral adiposity is related to insulin sensitivity and inflammation in adolescents with obesity and mild sleep disordered breathing. Journal of Pediatric Endocrinology and Metabolism 35(8): 1069–1077, Aug 2022 Notes: doi.org/10.1515/jpem-2021 published online July 11, 2022.

Higgins J, Zeitler P, Drews KL, Arslanian S, Copeland K, Goland R, Klingensmith G, Lipman TH, Tollefsen S; TODAY Study Group: ZnT8 autoantibody prevalence is low in youth with type 2 diabetes and associated with higher insulin sensitivity, lower insulin secretion, and lower disposition index. J Clin Transl Endocrinol 29: 100300. Journal of Clinical & Translational Endocrinology Volume 29, May 2022.

Shah RD, Braffett BH, Tryggestad JB, Hughan KS, Dhaliwal R, Nadeau KJ, Levitt Katz LE, Gidding SS. for The TODAY Study Group: Cardiovascular risk factor progression in adolescents and young adults with youth-onset type 2 diabetes. Journal of Diabetes and its Complications . 36(3), March 2022.

TODAY Study Group: Marsha D. Marcus, Rachelle Gandica, Laure El Ghormli, Janine Higgins, Bereket Tesfaldet, Dorit Koren, Sarah Macleish, Elia Nila Escaname, Ruth S. Weinstock: Longitudinal Association of Depressive Symptoms, Binge Eating, and Quality of Life With Cardiovascular Risk Factors in Young Adults With Youth-Onset Type 2 Diabetes: Diabetes Care 45 (1073-81), March 2022.

Amy S. Shah, MD, MS1; Samuel S. Gidding, MD2; Laure El ghormli, MS3; Jeanie B. Tryggestad, MD4; Kristen J. Nadeau, MD5; Fida Bacha, MD6; Lorraine E. Levitt Katz, MD7; Steven M. Willi, MD7; Joao Lima, MD8; Elaine M. Urbina, MD, MS9; for the TODAY Study Group : Relationship between Arterial Stiffness and Subsequent Cardiac Structure and Function in Young Adults with Youth-Onset Type 2 Diabetes: Results from the TODAY Study JASE 35(6), February 2022.

T. Blaine Crowley, Ian Campbell, Emily J. Liebling, Michele P. Lambert, Lorraine E. Levitt Katz, Jennifer Heimall, Donna McDonald McGinn, Kathleen E Sullivan : Distinct immune trajectories in patients with chromosome 22q11.2 deletion syndrome and immune-mediated diseases. Journal of Allergy and Clinical Immunology 149.(Issue 1): 445-450, Jan 2022.