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Diva D De Leon Crutchlow, M.D., M.S.C.E.

Professor of Pediatrics (Endocrinology and Diabetes) at the Children's Hospital of Philadelphia
Department: Pediatrics

Contact information
Division of Endocrinology/Diabetes
The Children's Hospital of Philadelphia
3500 Civic Center Blvd
Buerger Center for Advanced Pediatric Care
Room 12128
Philadelphia, PA 19104
Office: 267-426-0641
Fax: 267-425-0234
Lab: 267-426-0385
University of Panama, 1992.
M.S.C.E (Clinical Epidemiology)
Perelman School of Medicine at the University of Pennsylvania, 2012.
Post-Graduate Training
Rotating Internship, Complejo Hospitalario, Panama, Republic of Panama, 1992-1993.
Rotating Internship, Sistema Integrado de Salud de Azuero, Los Santos, Republic of Panama, 1993-1994.
Resident, Pediatrics, Monmouth Medical Center, Long Branch, NJ, 1996-1998.
Chief Resident, Pediatrics, Monmouth Medical Center, Long Branch, NJ, 1998-1999.
Pediatric Endocrinology Fellowship, The Children's Hospital of Philadelphia, 1999-2002.
Postdoctoral Fellow (NRSA fellowship training in Medicine-Diabetes/Endocrine), University of Pennsylvania, 2000-2001.
Postdoctoral Fellow (LWPES-Eli Lilly fellowship), University of Pennsylvania, 2001-2002.
Postdoctoral Fellow (Individual NRSA fellowship training), University of Pennsylvania, 2002-2003.
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Description of Research Expertise

Diva D. De León, M.D. is an Associate Professor of Pediatrics and a Pediatric Endocrinologist in the Division of Endocrinology and Diabetes at The Children's Hospital of Philadelphia. Dr. De León research interest focuses on congenital and acquired forms of hyperinsulinemic hypoglycemia. She is particularly interested in the role that alterations of the entero-insular axis may play in the pathophysiology of these disorders.

Description of Clinical Expertise

Dr. De León specializes in the diagnosis and management of monogenic disorders of insulin regulation resulting in diabetes and hypoglycemia. She is the Director of the Congenital Hyperinsulinism Center at The Children's Hospital of Philadelphia. Dr. De León predominantly cares for children with congenital and acquired forms of hyperinsulinemic hypoglycemia.

Selected Publications

Stanescu DE, Hughes N, Patel P, De León DD: A novel mutation in GATA6 causes pancreatic agenesis. Pediatr Diabetes 16(1): 67-70, Feb 2015.

Browning E, Wang H, Hong N, Yu K, Buerk DG, DeBolt K, Gonder D, Sorokina EM, Patel P, De León DD, Feinstein SI, Fisher AB and Chatterjee S: Mechanotransduction drives post ischemic revascularization through KATP channel closure and production of reactive oxygen species. Antioxidants & Redox Signaling 20(6): 872-86, Feb 2014.

Lord K, Dzata E, Snider KE, Gallagher PR, De León DD: Clinical presentation and management of children with diffuse and focal hyperinsulinism: a review of 223 cases. J Clin Endocrinol Metab 98(11): E1786-9, Nov 2013.

Calabria AC, Li C, Gallagher PR, Stanley CA, De León DD: GLP-1 receptor antagonist exendin-(9-39) elevates fasting blood glucose levels in congenital hyperinsulinism due to inactivating mutations in the ATP-sensitive K+ channel. Diabetes 61(10): 2585-91, Oct 2012.

Stanescu DE, Hughes N, Kaplan B, Stanley CA, De León DD: Novel presentations of congenital hyperinsulinism due to mutations in the MODY genes: HNF1A and HNF4A. J Clin Endocrinol Metab 97(10): E2026-30, Oct 2012.

Lin YW, Akrouh A, Hsu YC, Hughes N, Nichols CG, De León DD: Compound heterozygous mutations int eh SUR1 (ABCC 8) subunit of pancreatic K(ATP) channels cause neonatal diabetes by perturbing the coupling between Kir6.2 and SUR1 subunits. Channels (Austin) 6(2): 133-8, March-April 2012.

Calabria AC, Gallagher PR, Simmons R, Blinman T, De León DD: Postoperative surveillance and detection of postprandial hypoglycemia after fundoplasty in children. J Pediatr 159(4): 597-601, Oct 2011.

Pinney SE, Oliver-Krasinski J, Ernst L, Hughes N, Patel P, Stoffers DA, Russo P, De León DD: Neonatal diabetes and congenital malabsorptive diarrhea attributable to a novel mutation in the human neurogenin-3 gene coding sequence. J Clin Endocrinol Metab 96(7): 1960-5, Jul 2011.

Masia R, De León DD, MacMullen C, McKnight H, Stanley CA, Nichols CG: A mutations in the TMD0-L0 region of sulfonylurea receptor-1 (L225P) causes permanent neonatal diabetes mellitus (PNDM) Diabetes 56(5): 1357-62, May 2007.

De León DD, Stanley CA: Permanent Neonatal Diabetes Mellitus GeneReviews® [Internet] Pagon RA, Adam MP, Ardinger HH, et al., editors (eds.). Seattle (WA): University of Washington, Seattle; 1993-2016. Feb 2008 [Updated 2016 Jul 29] Notes: Available from: http://www.ncbi.nlm.nih.gov/books/NBK1447/

De León DD, Stanley CA, Sperling MA: Hypoglycemia in Neonates and Infants. Pediatric Endocrinology Sperling, MA (eds.). Saunders, 3rd edition, 2008.

De León DD, Li C, Delson MI, Matschinsky FM, Stanley CA, Stoffers DA: Exendin-(9-39) corrects fasting hypoglycemia in SUR-1-/- mice by lowering cAMP in pancreatic beta-cells and inhibiting insulin secretion. J Biol Chem 283(38): 25786-93, Sep 2008.

Palladino AA, Sayed S, Katz LE, Gallagher PR, De León DD: Increased glucagon-like peptide-1 secretion and post-prandial hypoglycemia in children after Nissen fundoplication. J Clin Endocrinol Metab 94(1): 39-44, Jan 2009.

De León DD: Role of Incretin Hormones in Hyperinsulinemic Hypoglycemia Frontiers in Diabetes: Monogenic Hyperinsulinemic Hypoglycemia Disorders. Stanley CA and De León DD (eds.). Karger, Basel, Switzerland, 21, Feb 2012.

De León DD, Stanley CA: Pathophysiology of Diffuse ATP-Sensitive Potassium Channel Hyperinsulinism. Frontiers in Diabetes: Monogenic Hyperinsulinemic Hypoglycemia Disorders. Stanley CA and De León DD (eds.). Karger, Basel, Switzerland, 21, Feb 2012.

Lord K, De León DD: Monogenic hyperinsulinemic hypoglycemia: current insights into the pathogenesis and management. Int J Pediatr Endocrinol 1: 3, Feb 2013.

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Last updated: 09/20/2023
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