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My research is on the regulation of cellular and tissue metabolism in vivo, with particular focus on the role of oxygen in tissue energy metabolism. This program covers several different tissues, including brain, liver, heart, and eye, and involves several models of ischemia/hypoxia and reoxygenation. We have developed an optical method for noninvasive measurement of oxygen, based on oxygen dependent quenching of phosphorescence, and are utilizing this technology for quantitative determine the oxygen dependence of tissue metabolism and function.
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Selected Publications
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Wilson DF, Cember ATJ, Matschinsky FM: Glutamate dehydrogenase: Role in regulating metabolism and insulin release in pancreatic β-cells. J Appl Physiol (1985). 2018 Apr 12. doi: 10.1152/japplphysiol.01077.2017 April 2018.
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Wilson DF: Oxidative phosphorylation: regulation and role in cellular and tissue metabolism. J Physiol. 2017 Dec 1;595(23):7023-7038. doi: 10.1113/JP273839. Epub 2017 Oct 29 595(23), Dec 2017.
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Pastuszko P, Schears GJ, Kubin J, Wilson DF, Pastuszko A.: Granulocyte colony-stimulating factor significantly decreases density of hippocampal caspase 3-positive nuclei, thus ameliorating apoptosis-mediated damage, in a model of ischaemic neonatal brain injury. Interact Cardiovasc Thorac Surg. 2017 Oct 1;25(4):600-605. doi: 10.1093/icvts/ivx047 25(4): 600-605, October 2017.
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Wilson DF, Cember ATJ, Matschinsky FM: The thermodynamic basis of glucose-stimulated insulin release: a model of the core mechanism. Physiol Rep. 2017 Jun;5(12). pii: e13327. doi: 10.14814/phy2.13327 5(12), June 2017.
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Kei T, Mistry N, Tsui AKY, Liu E, Rogers S, Doctor A, Wilson DF, Desjardins JF, Connelly K, Mazer CD, Hare GMT: Experimental assessment of oxygen homeostasis during acute hemodilution: the integrated role of hemoglobin concentration and blood pressure. Intensive Care Med Exp. 2017 Dec;5(1):12. doi: 10.1186/s40635-017-0125-6. Epub 2017 Mar 1 5(1), March 2017.
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Wilson DF: Oxidative phosphorylation: unique regulatory mechanism and role in metabolic homeostasis. J Appl Physiol (1985). 2017 Mar 1;122(3):611-619. doi: 10.1152/japplphysiol.00715.2016. Epub 2016 Oct 27 122(3): 611-619, March 2017.
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Wilson DF: Regulation of metabolism: the work-to-rest transition in skeletal muscle. Am J Physiol Endocrinol Metab. 2016 Apr 15;310(8):E633-E642. doi: 10.1152/ajpendo.00512.2015. Epub 2016 Feb 2 310(8): E633-E642, April 2016.
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Wilson DF: Regulation of metabolism: the rest-to-work transition in skeletal muscle. Am J Physiol Endocrinol Metab. 2015 Nov 1;309(9):E793-801. doi: 10.1152/ajpendo.00355.2015. Epub 2015 Sep 22. 309(9): E793-E801, September 2015.
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Wilson David F: Programming and regulation of metabolic homeostasis. American journal of physiology. Endocrinology and metabolism 308(6): E506-17, Mar 2015.
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Wilson David F, Harrison David K, Vinogradov Andrei: Mitochondrial cytochrome c oxidase and control of energy metabolism: measurements in suspensions of isolated mitochondria. Journal of applied physiology (Bethesda, Md. : 1985) 117(12): 1424-30, Dec 2014.
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Last updated: 06/25/2018
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The Trustees of the University of Pennsylvania
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