Selected Publications
For a complete list of publications, click here
Davila Antonio, Liu Ling, Chellappa Karthikeyani, Redpath Philip, Nakamaru-Ogiso Eiko, Paolella Lauren M, Zhang Zhigang, Migaud Marie E, Rabinowitz Joshua D, Baur Joseph A. Nicotinamide adenine dinucleotide is transported into mammalian mitochondria. eLife 7, June 2018.
Liu Ling, Su Xiaoyang, Quinn William J, Hui Sheng, Krukenberg Kristin, Frederick David W, Redpath Philip, Zhan Le, Chellappa Karthikeyani, White Eileen, Migaud Marie, Mitchison Timothy J, Baur Joseph A, Rabinowitz Joshua D. Quantitative Analysis of NAD Synthesis-Breakdown Fluxes. Cell metabolism 27(5): 1067-1080 .e5, May 2018.
Sims Carrie A, Guan Yuxia, Mukherjee Sarmistha, Singh Khushboo, Botolin Paul, Davila Antonio, Baur Joseph A. Nicotinamide mononucleotide preserves mitochondrial function and increases survival in hemorrhagic shock. JCI insight 3(17), Sep 2018.
Yoshino Jun, Baur Joseph A, Imai Shin-Ichiro. NAD Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell metabolism 27(3): 513-528, March 2018.
Chellappa Karthikeyani, Perron Isaac J, Naidoo Nirinjini, Baur Joseph A. The leptin sensitizer celastrol reduces age-associated obesity and modulates behavioral rhythms. Aging cell 18(3): e12874, Jun 2019.
Mukherjee Sarmistha, Chellappa Karthikeyani, Moffitt Andrea, Ndungu Joan, Dellinger Ryan W, Davis James G, Agarwal Beamon, Baur Joseph A. Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration. Hepatology (Baltimore, Md.) 65(2):616-630, Feb 2017.
Frederick DW, Loro E, Liu L, Davila A Jr, Chellappa K, Silverman IM, Quinn WJ 3rd, Gosai SJ, Tichy ED, Davis JG, Mourkioti F, Gregory BD, Dellinger RW, Redpath P, Migaud ME, Nakamaru-Ogiso E, Rabinowitz JD, Khurana TS, Baur JA. Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. Cell Metab. 2016 Aug 9;24(2):269-82.
Tran CM, Mukherjee S, Ye L, Frederick DW, Kissig M, Davis JG, Lamming DW, Seale P, Baur JA. Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue.Diabetes. 2016 Apr;65(4):927-41.
Frederick DW, Davis JG, Dávila A Jr, Agarwal B, Michan S, Puchowicz MA, Nakamaru-Ogiso E, Baur JA. Increasing NAD synthesis in muscle via nicotinamide phosphoribosyltransferase is not sufficient to promote oxidative metabolism. J Biol Chem. 2015 Jan 16;290(3):1546-58.
Naidoo N, Davis JG, Zhu J, Yabumoto M, Singletary K, Brown M, Galante R, Agarwal B, Baur JA. Aging and sleep deprivation induce the unfolded protein response in the pancreas: implications for metabolism. Aging Cell. 2014 Feb;13(1):131-41.
Zhang J, Zhu Y, Zhan G, Fenik P, Panossian L, Wang MM, Reid S, Lai D, Davis JG, Baur JA, Veasey S. Extended wakefulness: compromised metabolics in and degeneration of locus ceruleus neurons. J Neurosci. 2014 Mar 19;34(12):4418-31.
Lamming DW, Ye L, Astle CM, Baur JA, Sabatini DM, Harrison DE. Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive. Aging Cell. 2013 Aug;12(4):712-8.
Ye L, Widlund AL, Sims CA, Lamming DW, Guan Y, Davis JG, Sabatini DM, Harrison DE, Vang O,Baur JA. Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance.
Aging (Albany NY). 2013 Jul;5(7):539-50.
Lamming DW, Ye L, Sabatini DM, Baur JA. Rapalogs and mTOR inhibitors as anti-aging therapeutics. J Clin Invest. 2013 Mar 1;123(3):980-9.
Ye L, Varamini B, Lamming DW, Sabatini DM, Baur JA. Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2. Front Genet. 2012 Sep 11
Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science. 2012 Mar 30;335(6076):1638-43. Abstract | Reprint | Full Text
Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K., Shin Y-K, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martin-Montalvo A, Hubbard BP, Zhang Y, Lehrmann E, White AA, Price NL, Swindell WR, Pearson KJ, Becker KG, Bohr VA, Gorospe M, Egan JM, Talan MI, Auwerx J, Westphal CH, Ellis JL, Ungvari Z, Vlasuk GP, Elliott PJ, Sinclair DA, and de Cabo R. SRT1720 improves survival and healthspan of obese mice. Sci. Rep. 1:70 (2011).
Baur Joseph A: Resveratrol, sirtuins, and the promise of a DR mimetic. Mechanisms of ageing and development 131(4): 261-9, Feb 2010.
Armour Sean M, Baur Joseph A, Hsieh Sherry N, Land-Bracha Abigail, Thomas Sheila M, Sinclair David A: Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy. Aging 1(6): 515-28, Jun 2009.
Lou Zhenjun, Wei Jun, Riethman Harold, Baur Joseph A, Voglauer Regina, Shay Jerry W, Wright Woodring E: Telomere length regulates ISG15 expression in human cells. Aging 1(7): 608-21, Jul 2009.
Pearson Kevin J, Baur Joseph A, Lewis Kaitlyn N, Peshkin Leonid, Price Nathan L, Labinskyy Nazar, Swindell William R, Kamara Davida, Minor Robin K, Perez Evelyn, Jamieson Hamish A, Zhang Yongqing, Dunn Stephen R, Sharma Kumar, Pleshko Nancy, Woollett Laura A, Csiszar Anna, Ikeno Yuji, Le Couteur David, Elliott Peter J, Becker Kevin G, Navas Placido, Ingram Donald K, Wolf Norman S, Ungvari Zoltan, Sinclair David A, de Cabo Rafael: Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell metabolism 8(2): 157-68, Aug 2008.
Yang Hongying, Yang Tianle, Baur Joseph A, Perez Evelyn, Matsui Takashi, Carmona Juan J, Lamming Dudley W, Souza-Pinto Nadja C, Bohr Vilhelm A, Rosenzweig Anthony, de Cabo Rafael, Sauve Anthony A, Sinclair David A: Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell 130(6): 1095-107, Sep 2007.
Kim Dohoon, Nguyen Minh Dang, Dobbin Matthew M, Fischer Andre, Sananbenesi Farahnaz, Rodgers Joseph T, Delalle Ivana, Baur Joseph A, Sui Guangchao, Armour Sean M, Puigserver Pere, Sinclair David A, Tsai Li-Huei: SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. The EMBO journal 26(13): 3169-79, Jul 2007.
Baur Joseph A, Pearson Kevin J, Price Nathan L, Jamieson Hamish A, Lerin Carles, Kalra Avash, Prabhu Vinayakumar V, Allard Joanne S, Lopez-Lluch Guillermo, Lewis Kaitlyn, Pistell Paul J, Poosala Suresh, Becker Kevin G, Boss Olivier, Gwinn Dana, Wang Mingyi, Ramaswamy Sharan, Fishbein Kenneth W, Spencer Richard G, Lakatta Edward G, Le Couteur David, Shaw Reuben J, Navas Placido, Puigserver Pere, Ingram Donald K, de Cabo Rafael, Sinclair David A: Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444(7117): 337-42, Nov 2006.
Baur JA., Sinclair DA.: Therapeutic potential of resveratrol: the in vivo evidence. Nature Reviews in Drug Discovery 5(6): 337-342, 2006.
Baur J A, Zou Y, Shay J W, Wright W E: Telomere position effect in human cells. Science (New York, N.Y.) 292(5524): 2075-7, Jun 2001.