Publications

Fraietta Joseph A, Nobles Christopher L, Sammons Morgan A, Lundh Stefan, Carty Shannon A, Reich Tyler J, Cogdill Alexandria P, Morrissette Jennifer J D, DeNizio Jamie E, Reddy Shantan, Hwang Young, Gohil Mercy, Kulikovskaya Irina, Nazimuddin Farzana, Gupta Minnal, Chen Fang, Everett John K, Alexander Katherine A, Lin-Shiao Enrique, Gee Marvin H, Liu Xiaojun, Young Regina M, Ambrose David, Wang Yan, Xu Jun, Jordan Martha S, Marcucci Katherine T, Levine Bruce L, Garcia K Christopher, Zhao Yangbing, Kalos Michael, Porter David L, Kohli Rahul M, Lacey Simon F, Berger Shelley L, Bushman Frederic D, June Carl H, Melenhorst J Joseph: Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells. Nature 558(7709): 307-312, May 2018.

Ruella Marco, Xu Jun, Barrett David M, Fraietta Joseph A, Reich Tyler J, Ambrose David E, Klichinsky Michael, Shestova Olga, Patel Prachi R, Kulikovskaya Irina, Nazimuddin Farzana, Bhoj Vijay G, Orlando Elena J, Fry Terry J, Bitter Hans, Maude Shannon L, Levine Bruce L, Nobles Christopher L, Bushman Frederic D, Young Regina M, Scholler John, Gill Saar I, June Carl H, Grupp Stephan A, Lacey Simon F, Melenhorst J Joseph: Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell. Nature medicine 24(10): 1499-1503, Oct 2018.

Fraietta Joseph A, Lacey Simon F, Orlando Elena J, Pruteanu-Malinici Iulian, Gohil Mercy, Lundh Stefan, Boesteanu Alina C, Wang Yan, O'Connor Roddy S, Hwang Wei-Ting, Pequignot Edward, Ambrose David E, Zhang Changfeng, Wilcox Nicholas, Bedoya Felipe, Dorfmeier Corin, Chen Fang, Tian Lifeng, Parakandi Harit, Gupta Minnal, Young Regina M, Johnson F Brad, Kulikovskaya Irina, Liu Li, Xu Jun, Kassim Sadik H, Davis Megan M, Levine Bruce L, Frey Noelle V, Siegel Donald L, Huang Alexander C, Wherry E John, Bitter Hans, Brogdon Jennifer L, Porter David L, June Carl H, Melenhorst J Joseph: Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia. Nature medicine 24(5): 563-571, May 2018.

Long Kristen B, Young Regina M, Boesteanu Alina C, Davis Megan M, Melenhorst J Joseph, Lacey Simon F, DeGaramo David A, Levine Bruce L, Fraietta Joseph A: CAR T Cell Therapy of Non-hematopoietic Malignancies: Detours on the Road to Clinical Success. Frontiers in immunology 9: 2740, Dec 2018.

Long Kristen B, Gladney Whitney L, Tooker Graham M, Graham Kathleen, Fraietta Joseph A, Beatty Gregory L: IFNγ and CCL2 Cooperate to Redirect Tumor-Infiltrating Monocytes to Degrade Fibrosis and Enhance Chemotherapy Efficacy in Pancreatic Carcinoma. Cancer discovery 6(4): 400-413, Apr 2016.

Kawalekar Omkar U, O'Connor Roddy S, Fraietta Joseph A, Guo Lili, McGettigan Shannon E, Posey Avery D, Patel Prachi R, Guedan Sonia, Scholler John, Keith Brian, Snyder Nathaniel W, Snyder Nathaniel, Blair Ian A, Blair Ian, Milone Michael C, June Carl H: Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells. Immunity 44(2): 380-90, Feb 2016.

Fraietta Joseph A, Beckwith Kyle A, Patel Prachi R, Ruella Marco, Zheng Zhaohui, Barrett David M, Lacey Simon F, Melenhorst Jan Joseph, McGettigan Shannon E, Cook Danielle R, Zhang Changfeng, Xu Jun, Do Priscilla, Hulitt Jessica, Kudchodkar Sagar B, Cogdill Alexandria P, Gill Saar, Porter David L, Woyach Jennifer A, Long Meixiao, Johnson Amy J, Maddocks Kami, Muthusamy Natarajan, Levine Bruce L, June Carl H, Byrd John C, Maus Marcela V: Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia. Blood 127(9): 1117-27, Mar 2016.

Johnson Laura A, Scholler John, Ohkuri Takayuki, Kosaka Akemi, Patel Prachi R, McGettigan Shannon E, Nace Arben K, Dentchev Tzvete, Thekkat Pramod, Loew Andreas, Boesteanu Alina C, Cogdill Alexandria P, Chen Taylor, Fraietta Joseph A, Kloss Christopher C, Posey Avery D, Engels Boris, Singh Reshma, Ezell Tucker, Idamakanti Neeraja, Ramones Melissa H, Li Na, Zhou Li, Plesa Gabriela, Seykora John T, Okada Hideho, June Carl H, Brogdon Jennifer L, Maus Marcela V: Rational development and characterization of humanized anti-EGFR variant III chimeric antigen receptor T cells for glioblastoma. Science translational medicine 7(275): 275ra22, Feb 2015.

Fraietta Joseph A, Mueller Yvonne M, Yang Guibin, Boesteanu Alina C, Gracias Donald T, Do Duc H, Hope Jennifer L, Kathuria Noshin, McGettigan Shannon E, Lewis Mark G, Giavedoni Luis D, Jacobson Jeffrey M, Katsikis Peter D: Type I interferon upregulates Bak and contributes to T cell loss during human immunodeficiency virus (HIV) infection. PLoS pathogens 9(10): e1003658, Oct 2013.

Gracias Donald T, Stelekati Erietta, Hope Jennifer L, Boesteanu Alina C, Doering Travis A, Norton Jillian, Mueller Yvonne M, Fraietta Joseph A, Wherry E John, Turner Martin, Katsikis Peter D: The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling. Nature immunology 14(6): 593-602, Jun 2013.