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Goodman Lab

Publications

List of Recent Publications

  1. Chang CR, Vykunta VS, Lee JHJ, Li K, Kochendoerfer C, Muldoon JJ, Wang CH, Mazumder T, Sun Y, Goodman DB, Nyberg WA, Liu C, Allain V, Rothrock A, Ye CJ, Marson A, Shy BR, Eyquem J. SEED-Selection enables high-efficiency enrichment of primary T cells edited at multiple loci. Nat Biotechnol. 2025;1–11. doi:10.1038/s41587-024-02531-6

  2. Garcia J*, Daniels J*, Lee Y, Zhu I, Cheng K, Liu Q, Goodman D, Burnett C, Law C, Thienpont C, Alavi J, Azimi C, Montgomery G, Roybal KT, Choi J. Naturally occurring T cell mutations enhance engineered T cell therapies. Nature. 2024;626(7999): 626–634. doi:10.1038/s41586-024-07018-7

  3. Blaeschke F, Chen YY, Apathy R, Daniel B, Chen AY, Chen PA, Sandor K, Zhang W, Li Z, Mowery CT, Yamamoto TN, Nyberg WA, To A, Yu R, Bueno R, Kim MC, Schmidt R, Goodman DB, Feuchtinger T, Eyquem J, Jimmie Ye C, Carnevale J, Satpathy AT, Shifrut E, Roth TL, Marson A. Modular pooled discovery of synthetic knockin sequences to program durable cell therapies. Cell. 2023;186(19): 4216–4234.e33. doi:10.1016/j.cell.2023.08.013

  4. Goodman DB*, Azimi C*, Kearns K, Talbot A, Garakani K, Garcia JM, Patel N, Hwang B, Lee DS, Park E, Vykunta VS, Shy B, Ye CJ, Eyquem J, Marson A, Bluestone J, Roybal KT. Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies. Sci Transl Med. 2022;14: eabm1463–eabm1463. doi:10.1126/scitranslmed.abm1463

  5. Schubert MG*, Goodman DB*, Wannier TM, Kaur D, Farzadfard F, Lu TK, Shipman SL, Church GM. High-throughput functional variant screens via in vivo production of single-stranded DNA. Proc Natl Acad Sci U S A. 2021;118(18): . doi:10.1073/pnas.2018181118

  6. Nguyen DN, Roth TL, Li PJ, Chen PA, Apathy R, Mamedov MR, Vo LT, Tobin VR, Goodman D, Shifrut E, Bluestone JA, Puck JM, Szoka FC, Marson A. Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency. Nat Biotechnol. 2020;38(1): 44–49. doi:10.1038/s41587-019-0325-6

  7. Chan Y, Chan YK, Goodman DB, Guo X, Chavez A, Lim ET, Church GM. Enabling multiplexed testing of pooled donor cells through whole-genome sequencing. Genome Med. 2018;10(1): 31. doi:10.1186/s13073-018-0541-6

  8. Kuznetsov G*, Goodman DB*, Filsinger GT*, Landon M, Rohland N, Aach J, Lajoie MJ, Church GM. Optimizing complex phenotypes through model-guided multiplex genome engineering. Genome Biol. 2017;18(1): 100. doi:10.1186/s13059-017-1217-z

  9. Goodman DB*, Kuznetsov G*, Lajoie MJ, Ahern BW, Napolitano MG, Chen KY, Chen C, Church GM. Millstone: software for multiplex microbial genome analysis and engineering. Genome Biol. 2017;18(1): 101. doi:10.1186/s13059-017-1223-1

  10. Lajoie MJ*, Rovner AJ*, Goodman DB, Aerni H, Haimovich AD, Kuznetsov G, Mercer JA, Wang HH, Carr PA, Mosberg JA, Rohland N, Schultz PG, Jacobson JM, Rinehart J, Church GM, Isaacs FJ. Genomically recoded organisms expand biological functions. Science. 2013;342(6156): 357–360. doi:10.1126/science.1241459

  11. Kosuri S*, Goodman DB*, Cambray G, Mutalik VK, Gao Y, Arkin AP, Endy D, Church GM. Composability of regulatory sequences controlling transcription and translation in Escherichia coli. Proc Natl Acad Sci U S A. 2013;110(34): 14024–14029. doi:10.1073/pnas.1301301110

  12. Goodman DB, Church GM, Kosuri S. Causes and effects of N-terminal codon bias in bacterial genes. Science. 2013;342(6157): 475–479. doi:10.1126/science.1241934

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