Milone Lab
Michael Milone, MD, PhD
Associate Professor of Pathology and Laboratory Medicine
Associate Director, Toxicology Laboratory
Michael Milone is an Associate Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania and the School of Medicine. He earned his MD and PhD in 1999 from the University of Medicine and Dentistry of New Jersey. His doctoral work focused upon the unique interactions between plasmacytoid dendritic cells and viruses that stimulate abundant type I interferon production by this dendritic cell subset. He went on to post-graduate medical training in internal medicine, laboratory medicine and transfusion medicine at the University of Pennsylvania. Dr. Milone continued his scientific research studies during a post-doctoral fellowship pursuing adoptive immunotherapy of cancer with Dr. Carl June at the University of Pennsylvania. This work has lead to an open Phase I study of artificial antigen receptors in patients with B cell leukemia and lympohma. Joining the faculty in 2007, Dr. Milone's laboratory continues to focus upon genetic engineering and adoptive immunotherapy of cancer with new approaches based upon work within the NCMDIR that began in 2008 when he joined the nanomedicine initiative as the center's clinical collaborator.
Research Interests
Dr. Milone is interested in improving cancer and transplantation therapy through the development of new immunotherapeutic modalities. Active research projects in my laboratory include:
- Developing improved chimeric antigen receptors (CARs) for adoptive immunotherapy of cancer.
- Developing novel T cell stimulatory substrates based upon nano- and micro-fabricated surfaces for control of T cell proliferation and differentiation.
Contact
Associate Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Associate Director, Toxicology Laboratory
3400 Civic Center Blvd
Building 421, SPE 8-101
Philadelphia, PA 19104
(215) 573-5163 Phone
(215) 573-6000 Research Lab
milone@pennmedicine.upenn.edu
Jennifer Wolfe
Administrative Staff Supervisor
Department of Pathology & Laboratory Medicine
University of Pennsylvania
M163 John Morgan Building
3620 Hamilton Walk
Philadelphia PA 19104
Phone: 215-746-1906
wolfejen@pennmedicine.upenn.edu