O'Connor Lab


1. Liu, M., R. S. O'Connor, S. Trefely, K. Graham, N. W. Snyder and G. L. Beatty (2019). "Metabolic rewiring of macrophages by 
CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated 'don't-eat-me' signal." 
Nat Immunol 20(3): 265-275.
2. Ghassemi, S., S. Nunez-Cruz, R. S. O'Connor, J. A. Fraietta, P. R. Patel, J. Scholler, D. M. Barrett, S. M. Lundh, M. M. Davis, F. Bedoya,
 C. Zhang, J. Leferovich, S. F. Lacey, B. L. Levine, S. A. Grupp, C. H. June, J. J. Melenhorst and M. C. Milone (2018). 
"Reducing Ex Vivo Culture Improves the Antileukemic Activity of Chimeric Antigen Receptor (CAR) T Cells.”
 Cancer Immunol Res 6(9): 1100-1109.
3. Fraietta, J. A., S. F. Lacey, E. J. Orlando, I. Pruteanu-Malinici, M. Gohil, S. Lundh, A. C. Boesteanu, Y. Wang, R. S. O'Connor, 
W. T. Hwang, E. Pequignot, D. E. Ambrose, C. Zhang, N. Wilcox, F. Bedoya, C. Dorfmeier, F. Chen, L. Tian, H. Parakandi, 
M. Gupta, R. M. Young, F. B. Johnson, I. Kulikovskaya, L. Liu, J. Xu, S. H. Kassim, M. M. Davis, B. L. Levine, N. V. Frey, 
D. L. Siegel, A. C. Huang, E. J. Wherry, H. Bitter, J. L. Brogdon, D. L. Porter, C. H. June and J. J. Melenhorst (2018). 
"Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic 
lymphocytic leukemia." Nat Med 24(5): 563-571.
4. June, C. H., R. S. O'Connor, O. U. Kawalekar, S. Ghassemi and M. C. Milone (2018).
 "CAR T cell immunotherapy for human cancer." Science 359(6382): 1361-1365.
5. O'Connor, R. S., L. Guo, S. Ghassemi, N. W. Snyder, A. J. Worth, L. Weng, Y. Kam, B. Philipson, S. Trefely, S. Nunez-Cruz,
 I. A. Blair, C. H. June and M. C. Milone (2018). "The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly 
used concentrations." Sci Rep 8(1): 6289.
6. Hippen, K. L., R. S. O'Connor, A. M. Lemire, A. Saha, E. A. Hanse, N. C. Tennis, S. C. Merkel, A. Kelekar,
 J. L. Riley, B. L. Levine, C. H. June, L. A. Turka, L. S. Kean, M. L. MacMillan, J. S. Miller, J. E. Wagner,
 D. H. Munn and B. R. Blazar (2017). "In Vitro Induction of Human Regulatory T Cells Using Conditions
 of Low Tryptophan Plus Kynurenines." Am J Transplant 17(12): 3098-3113.
7. Lambert, L. H., G. K. Goebrecht, S. E. De Leo, R. S. O'Connor, S. Nunez-Cruz, T. D. Li, J. Yuan, M. C. Milone and L. C. Kam (2017). 
"Improving T Cell Expansion with a Soft Touch." Nano Lett 17(2): 821-826.
8. Kawalekar, O. U., R. S. O'Connor, J. A. Fraietta, L. Guo, S. E. McGettigan, A. D. Posey, Jr., P. R. Patel, S. Guedan,
 J. Scholler, B. Keith, N. W. Snyder, I. A. Blair, M. C. Milone and C. H. June (2016).
 "Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in 
CAR T Cells." Immunity 44(2): 380-390.
9. Saha, A., R. S. O'Connor, G. Thangavelu, S. B. Lovitch, D. B. Dandamudi, C. B. Wilson, 
B. G. Vincent, V. Tkachev, J. M. Pawlicki, S. N. Furlan, L. S. Kean, K. Aoyama, P. A. Taylor, A. Panoskaltsis-Mortari, R. Foncea, 
P. Ranganathan, S. M. Devine, J. S. Burrill, L. Guo, C. Sacristan, N. W. Snyder, I. A. Blair, M. C. Milone, M. L. Dustin, J. L. Riley, 
D. A. Bernlohr, W. J. Murphy, B. T. Fife, D. H. Munn, J. S. Miller, J. S. Serody, G. J. Freeman, A. H. Sharpe, L. A. Turka and
 B. R. Blazar (2016). "Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality.”
 J Clin Invest 126(7): 2642-2660.
10. Hu, J., A. A. Gondarenko, A. P. Dang, K. T. Bashour, R. S. O'Connor, S. Lee, A. Liapis, S. Ghassemi, M. C. Milone, 
M. P. Sheetz, M. L. Dustin, L. C. Kam and J. C. Hone (2016).
 "High-Throughput Mechanobiology Screening Platform Using Micro- and Nanotopography." Nano Lett 16(4): 2198-2204.
11. Xiang, Y., Z. E. Stine, J. Xia, Y. Lu, R. S. O'Connor, B. J. Altman, A. L. Hsieh, A. M. Gouw, A. G. Thomas, P. Gao, L. Sun,
 L. Song, B. Yan, B. S. Slusher, J. Zhuo, L. L. Ooi, C. G. Lee, A. Mancuso, A. S. McCallion, A. Le, M. C. Milone, 
S. Rayport, D. W. Felsher and C. V. Dang (2015). "Targeted inhibition of tumor-specific glutaminase 
diminishes cell-autonomous tumorigenesis." J Clin Invest 125(6): 2293-2306.
12. O'Connor, R. S., X. Hao, K. Shen, K. Bashour, T. Akimova, W. W. Hancock, L. C. Kam and M. C. Milone (2012). 
"Substrate rigidity regulates human T cell activation and proliferation." J Immunol 189(3): 1330-1339.
13. Babich, A., S. Li, R. S. O'Connor, M. C. Milone, B. D. Freedman and J. K. Burkhardt (2012).
 "F-actin polymerization and retrograde flow drive sustained PLCgamma1 signaling during T cell activation." 
J Cell Biol 197(6): 775-787.
14. Reichek, J. L., F. Duan, L. M. Smith, D. M. Gustafson, R. S. O'Connor, C. Zhang, M. J. Dunlevy,
 J. M. Gastier-Foster and F. G. Barr (2011). "Genomic and clinical analysis of amplification of the 
13q31 chromosomal region in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group.”
 Clin Cancer Res 17(6): 1463-1473.

15. O'Connor, R. (2008). "Concealed cargo within the tumor microenvironment: microvesicles disseminate 
oncogenic receptors among cancer cells." Cancer Biol Ther 7(9): 1350-1351.

16. O'Connor, R. S., C. M. Steeds, R. W. Wiseman and G. K. Pavlath (2008).
 "Phosphocreatine as an energy source for actin cytoskeletal rearrangements during myoblast fusion.”
 J Physiol 586(12): 2841-2853.

17. O'Connor, R. S. and G. K. Pavlath (2007). "Point:Counterpoint: Satellite cell addition is/is not obligatory for 
skeletal muscle hypertrophy." J Appl Physiol (1985) 103(3): 1099-1100.
18. O'Connor, R. S., G. K. Pavlath, J. J. McCarthy and K. A. Esser (2007). "Last Word on Point:Counterpoint: Satellite cell 
addition is/is not obligatory for skeletal muscle hypertrophy." J Appl Physiol (1985) 103(3): 1107.

19. O 'Connor, R. S., S. T. Mills, K. A. Jones, S. N. Ho and G. K. Pavlath (2007). 
"A combinatorial role for NFAT5 in both myoblast migration and differentiation during skeletal muscle 
myogenesis." J Cell Sci 120(Pt 1): 149-159.

20. Mitchell, P. O., T. Mills, R. S. O'Connor, E. R. Kline, T. Graubert, E. Dzierzak and G. K. Pavlath (2005).
 "Sca-1 negatively regulates proliferation and differentiation of muscle cells." Dev Biol 283(1): 240-252.