Powell Lab

T cells play a major role in controlling the progression of human cancer

technique to study ovarian cancer-reactive T cells

In one research area, the Powell lab studies rare tumor-reactive T cells in patient-derived tumors, and is applying this new-found knowledge as a “roadmap” for the rational design of cancer immunotherapy trials using checkpoint inhibitors. In another, the Powell lab is developing innovative, advanced gene-engineering approaches to generate tumor-reactive T cells outside of the body for adoptive transfer therapy of cancer.
The missions of the Powell laboratory include the following:

  • Understand the immunobiology of human cancer. How can we strengthen the patient’s own immune cells to cure cancer?
  • Develop novel chimeric antigen receptor (CAR) and T cell receptor (TCR) platforms that deliver effective and safe T cell therapy for patients.
  • To develop improved in vivo model systems to test promising immunotherapy modalities, including therapies for companion pets.
  • Translate basic science into clinical trials for ovarian cancer.