Riley Lab

Recent Research Publications

  1. Varela-Rohena A, Molloy PE, Dunn SM, Li Y, Suhoski MM, Carroll RG, Milicic A, Mahon T, Sutton DH, Laugel B, Moysey R, Cameron BJ, Vuidepot A, Purbhoo MA, Cole DK, Phillips RE, June CH, Jakobsen BK, Sewell AK, Riley JL: Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor. Nature Medicine 14(12): 1390-5, Dec 2008.
  2. Basu S, Golovina T, Mikheeva T, June CH, Riley JL: Cutting edge: Foxp3-mediated induction of pim 2 allows human T regulatory cells to preferentially expand in rapamycin. Journal of Immunology 180(9): 5794-8, May 2008.
  3. Riley JL, June CH, Blazar BR: Human T regulatory cell therapy: take a billion or so and call me in the morning. Immunity 30(5): 656-65, May 2009.
  4. Richardson MW, Jadlowsky J, Didigu CA, Doms RW, Riley JL:Kruppel-like factor 2 modulates CCR5 expression and susceptibility to HIV-1 infection. Journal of Immunology 189(8): 3815-21, Oct 2012.
  5. Plesa G, Zheng L, Medvec A, Wilson CB, Robles-Oteiza C, Liddy N, Bennett AD, Gavarret J, Vuidepot A, Zhao Y, Blazar BR, Jakobsen BK, Riley JL: TCR affinity and specificity requirements for human regulatory T-cell function. Blood 119(15): 3420-30, Apr 2012.
  6. Rech AJ, Mick R, Martin S, Recio A, Aqui NA, Powell DJ, Colligon TA, Trosko JA, Leinbach LI, Pletcher CH, Tweed CK, DeMichele A, Fox KR, Domchek SM, Riley JL, Vonderheide RH: CD25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patients. Science Translational Medicine 4(134): 134ra62, May 2012.
  7. Riley JL: Combination checkpoint blockade--taking melanoma immunotherapy to the next level. The New England Journal of Medicine 369(2): 187-9, Jul 2013.
  8. Wei F, Zhong S, Ma Z, Kong H, Medvec A, Ahmed R, Freeman GJ, Krogsgaard M, Riley JL: Strength of PD-1 signaling differentially affects T-cell effector functions. Proceedings of the National Academy of Sciences of the United States of America 110(27): E2480-9, Jul 2013.
  9. Richardson MW, Guo L, Xin F, Yang X, Riley JL: Stabilized human TRIM5α protects human T cells from HIV-1 infection. Molecular Therapy 22(6): 1084-95, Jun 2014.
  10. Leibman RS, Riley JL: Engineering T Cells to Functionally Cure HIV-1 Infection. Molecular Therapy 23(7): 1149-59, Jul 2015.