Sheppard Lab


  1. Tang Y, Liu W, Kadu S, Johnson O, Hasanali S, Kelly A, Shestov A, Greenblatt E, Holmes M, Wang L, Shih N, O’Connor RS, Garfall AL, Allman D, Vogl DT, Cohen A, June CH, & Sheppard NC (2023) Exploiting the CD200-CD200R Immune Checkpoint Axis in Multiple Myeloma to Enhance CAR-T Therapy, Blood,2022018658 PubMed PMID 37616575
  2. Zhang C, Kadu S, Xiao Y, Johnson O, Kelly A, O’Connor RS, Lai M, Kong H, Srivatsa S, Tai V, Greenblatt E, Holmes M, Riley JL, June CH, & Sheppard NC (2023) Sequential Exposure to Interleukin-21 and Interleukin-15 During Human Natural Killer Cell Expansion Optimizes Yield and Function, Cancer Immunology Research, doi: 10.1158/2326-6066.CIR-23-0151. PubMed PMID 37649085
  3. Mai D, Johnson O, Reff J, Fan TJ, Scholler J, Sheppard NC, June CH (2023) Combined disruption of T cell inflammatory regulators Regnase-1 and Roquin-1 enhances antitumor activity of engineered human T cells, PNAS 120(12): e2218632120. PubMed PMID 36920923
  4. Hamilton AG, Swingle KL, Joseph RA, Mai D, Gong N, Billingsley MM, Alameh MG, Weissman D, Sheppard NC, June CH, Mitchell MJ. (2023) Ionizable Lipid Nanoparticles with Integrated Immune Checkpoint Inhibition for mRNA CAR T Cell Engineering. Adv Healthc Mater, e2301515. PubMed PMID 37602495
  5. Zhong W, Xiao Z, Qin Z, Yang J, Wen Y, Yu Z, Li Y, Sheppard NC, Fuchs SY, Xu X, Herlyn M, June CH, Puré E, Guo W. Tumor-Derived Small Extracellular Vesicles Inhibit the Efficacy of CAR T Cells against Solid Tumors (2023) Cancer Res 83(16):2790-2806. PubMed PMID 37115855
  6. Haas AR, Golden RJ, Litzky LA, Engels B, Zhao L, Xu F, Taraszka JA, Ramones M, Granda B, Chang WJ, Jadlowsky J, Shea KM, Runkle A, Chew A, Dowd E, Gonzalez V, Chen F, Liu X, Fang C, Jiang S, Davis MM, Sheppard NC, Zhao Y, Fraietta JA, Lacey SF, Plesa G, Melenhorst JJ, Mansfield K, Brogdon JL, Young RM, Albelda SM, June CH, Tanyi JL. (2023) Two cases of severe pulmonary toxicity from highly active mesothelin-directed CAR T cells, Molecular Therapy 31(8):2309-2325. PubMed PMID 37312454
  7. Berjis A, Muthumani D, Sheppard NC, June CH. (2023) Swiss army knife T cell: one T cell many tumor targets, Cell Research doi: 10.1038/s41422-023-00871-7. PubMed PMID 37666977
  8. Mai D, June CH, & Sheppard NC (2022) In vivo gene immunotherapy for cancer, Science Translational Medicine, 14(670):eabo3603. PubMed PMID 36350990
  9. Billingsley MM, Hamilton AG, Mai D, Patel SK, Swingle KL, Sheppard NC, June CH, Mitchell MJ. (2022) Orthogonal Design of Experiments for Optimization of Lipid Nanoparticles for mRNA Engineering of CAR T Cells, Nano Letters 22(1):533-542.  PubMed PMID 34669421
  10. Ellis GI, Sheppard NC, Riley JL. (2021) Genetic engineering of T cells for immunotherapy, Nature Reviews Genetics 22(7):427-447. PubMed PMID 33603158
  11. Gong N, Sheppard NC, Billingsley MM, June CH, Mitchell MJ. (2021) Nanomaterials for T-cell cancer immunotherapy, Nature Nanotechnology 16(1):25-36. PubMed PMID 33437036