Siegel Lab
Don L. Siegel, PhD, MD
Professor, Pathology & Laboratory Medicine
Director, Division of Transfusion Medicine & Therapeutic Pathology
Director, Clinical Cell & Vaccine Production Facility
Dr. Siegel received an undergraduate degree in Biophysics from Brown University, a Ph.D. in Biophysics from Harvard University, and an M.D. from the University of Pennsylvania. He completed a residency in Clinical Pathology and Fellowship in Blood Banking/Transfusion Medicine at the Hospital of the University of Pennsylvania before joining Penn as a member of the faculty in 1992.
At the Hospital of the University of Pennsylvania, Dr. Siegel serves as the medical director of the blood bank, apheresis unit, hematopoietic stem cell laboratory, and an NIH T32-supported ACGME-accredited transfusion medicine fellowship program. Within the University, Dr. Siegel serves as Director of the Clinical Cell and Vaccine Production facility, a FACT-accredited, shared GMP resource within the Center for Cellular Immunotherapies and the Division of Transfusion Medicine & Therapeutic Pathology.
In 2013, Dr. Siegel was elected to the first class of Penn Medicine’s Academy of Master Clinicians and more recently was awarded the Research Innovation in Scientific Excellence from the American Association of Blood Banks, the Francis S. Morrison Award and the Lecturer Award from the American Society of Apheresis, and the Gift of Life Award from the Ree Wynn Foundation for his work in autoimmune immunohematology and cellular therapy.
Research Interests
Dr. Siegel’s laboratory has been funded by the NIH in the areas of immunohematology, hemostasis/thrombosis, autoimmunity, and oncology since 1992. His laboratory has focused on the study of human auto and alloimmune repertoires in health and disease using repertoire cloning approaches (phage and yeast display technologies) for the production of monoclonal antibodies relevant to transfusion medicine, benign hematology, infectious diseases, and cancer.
Contact
Director, Transfusion Medicine & Therapeutic Pathology
3 White Building, HUP
3400 Spruce Street
Philadelphia, PA 19104
(215) 662-3942 (office)
Director, Clinical Cell & Vaccine Production Facility
Center for Advanced Cellular Therapies
South Pavilion, Rm 9-112
3400 Civic Center Blvd, Bldg 421
Philadelphia, PA 19104
(215) 898-9655 (laboratory)
siegeld@pennmedicine.upenn.edu