Publications

Narayan, V., Barber-Rotenberg, J.S., Jung, I.Y., Lacey, S.F., Rech, A.J., Davis, M.M., Hwang, W.-T., Lai, P., Carpenter, E.L., Maude, S.L., Plesa, G., Vapiwala, N., Chew, A., Moniak, M., Sebro, R.A., Farwell, M.D., Marshall, A., Gilmore, J., Lledo, L., Dengel, K., Church, S.e., Hether, T.D., Xu, J., Gohil, M., Buckingham, T.H., Yee, S.S., Gonzalez, V.E., Kulikovskaya, I., Chen, F., Tian, L., Tien, K., Gladney, W., Nobles, C.L., Raymond, H., Prostate Cancer Cellular Therapy Program Investigators, Hexner, E.O., Siegel, D.L., Bushman, F.D., June, C.H., Fraietta, J.A., Haas, N.B. PSMA-redirected TGFb-insensitive armored CAR T cell to treat metastatic castration resistant prostate cancer, Nature Medicine, in press.

Melenhorst, J.J., Chen, G.M., Wang, M., Porter, D.L., Gao, P., Bandyopadhyay, S., Pruteanu-Malinici, I., Nobles, C.L., Maji, S., Frey, N.V., Gill, S.I., Tian, L., Kulikovskaya, I., Gupta, M., Davis, M.M., Fraietta, J.A., Brogdon, J.L., Young, R.M., Ambrose, D.E., Chew, A., Levine, B.L., Siegel, D.L., Alanio, C., Wherry, E.J., Bushman, F.D., Lacey, S.F., Tan^,, K., June^, C.H.: Decade-long remissions of leukemia sustained by the persistence of activated CD4+ CAR T-cell, Nature 602:503-509, 2022

Mason, N.J., Chester, N., Xiong, A., Rotolo, A., Wu, Y., Glassman, P., Gulendan, G., Siegel, D.L.: Development of a fully canine anti-canine CTLA4 monoclonal antibody for comparative translational research in dogs with spontaneous tumors, mAbs, 13:e2004638

Bar, K.J., Shaw, P.A., Choi, G.H., Aqui, N., Fesnak, A., Yang, J.B., Soto-Calderon, H., Grajales, L., Starr, J., Andronov, M., Mastellone, M., Amonu, C., Feret, G., DeMarshall, M., Buchanan, M., Caturla, M., Gordon, J., Wanicur, A., Monroy, M.A., Mampe, F., Lindemuth, E., Gouma, S., Mullin, A.M., Barilla, H., Pronina, A., Irwin, L., Thomas, R., Eichinger, R.A., Demuth, F., Luning Prak, E.T., Pascual, J.L., Short, W., Elovitz, M.A., Baron, J., Meyer, N.J., Degnan, K.O., Frank, I., Hensley, S., Siegel, D.L., Tebas, P.:  A randomized controlled study of convalescent plasma for individuals hospitalized with COVID-19 pneumonia, J. Clin. Invest., 131:e15511, 2021.

Tutwiler, V., Litvinov, R.I., Protopopova, A., Nagaswami, C., Villa, C., Abdulmalik, O., Siegel, D.L., Eric Russell, E.R., Muzykantov, V.R., Lam, W.A., Myers, D.R., Weisel, J.W.:  Pathologically stiff erythrocytes can promote thrombosis by impeding contraction of blood clots, J. Thromb. Haemost., 10.1111/jth.15407, 2021.

Myers, R.M., Li, Y., Leahy, A.B., Barrett, D.M., Teachey, D.T., Callahan, C., Fasano, C.C., Rheingold, S.R., DiNofia, A., Wray, L. Aplenc, R.,  Baniewicz, D., Liu, H., Shaw, P.A., Pequignot, E., Getz, K.D., Brogdon, J.L.,  Fesnak, A.D., Siegel, D.L., Davis, M.M., Bartoszek, C., Lacey, S.F., Hexner, E.O., Chew, A., Wertheim, G.B., Levine, B.L., June, C.H., Grupp, S.A., Maude, S.L.: Humanized CD19-targeted Chimeric Antigen Receptor (CAR) T cells in CAR-naïve and CAR-exposed children and young adults with relapsed/refractory acute lymphoblastic leukemia, J. Clin. Oncol., 39:3044-3055, 2021.

Halkidis, K., Siegel, D.L., Zheng, X.L.: A human monoclonal antibody against the C-terminus of ADAMTS13 modulates its susceptibility to an inhibitor in thrombotic thrombocytopenic purpura, J. Thromb Haemos, 19:1888-1895, 2021.

Tebas, P., Jadlowsky, J.K., Shaw, P.A., Tian, L., Esparza, E., Brennan, A., Kim, S., Naing, S.Y., Richardson, M.W., Vogel, A.N., Maldini, C., Kong, H., Liu, X., Lacey, S.F., Bauer, A.M., Mampe, F., Lee, G., Dale Ando, D., Levine, B.D., Porter, D.L., Zhao, Y., Siegel, D.L., Bar, K.J., June, C.H., Riley, J.L.: CCR5-edited CD4 T cells augment HIV-specific immunity to enable post rebound control of HIV replication, J. Clin. Invest., 131:e144486, 2021.

Bhoj, V., Li,^, L., Parvathaneni, K., Zhang, Z., Kacir, S., Arhontoulis, D., Zhou, K., McGettigan-Croce, B., Nunez-Cruz, S., Gulendran,^, G., Boesteanu, A.C., Johnson, L., Feldman, M.D., Radaelli, E., Mansfield, K., Nasrallah, M., Goydel,^, R., Peng, H., Rader, C.,  Milone, M.C., Siegel, D.L.:  Adoptive T cell immunotherapy for medullary thyroid carcinoma targeting GDNF family receptor alpha 4 (GFRa4), Molecular Therapy – Oncolytics, 20:387-398, 2021.

Diorio, C., Shaw, P.A., Pequignot, E., Orlenko, A., Chen, F., Aplenc, R., Barrett, D.M., Bassiri, H., Behrens, E., DiNofia, A.M., Gonzalez, V., Koterba, N., Levine, B.L., Maude, S.L., Meyer, N.J., Moore, J.H., Paessler, M., Porter, D.L., Bush, J.L., Siegel, D.L., Davis, M.M., Zhang, D., June, C.H., Grupp, S..A., Melenhorst, J.J., Lacey, S.F., Weiss, S.L., Teachey, D.T.: Diagnostic biomarkers to differentiate sepsis from cytokine release syndrome in critically ill children, Blood Adv., 4:5174-5183, 2020.

Stadtmauer, E.A., Fraietta, J.A., Davis, M.M., Cohen, A.D., Weber, K.L., Lancaster, E., Mangan, P.A., Kulikovskaya, I., Gupta, M., Chen, F., Tian, L., Gonzalez, V.E., Xu, J., Jung, I.Y., Melenhorst, J.J., Plesa, G., Shea, J., Matlawski, T., Cervini, A., Gaymon, A.L., Desjardins, S., Lamontagne, A., Salas-Mckee, J., Fesnak, A., Siegel, D.L., Levine, B.L., Jadlowsky, J.K., Young, R.M., Chew, A., Hwang, W.-T., Hexner, E.O., Carreno, B.M., Nobles, C.L., Bushman, F.D., Parker, K.R., Qi, Y., Satpathy, A.T., Chang, H.Y., Zhao, Y., Lacey, S.F., June, C.H.:  CRISPR-engineered T cells in patients with refractory cancer, Science, Feb 6 [Epub ahead of print], 2020

He, X., Feng, Z., Ma, J., Ling, S., Cao, Y., Gurung, B., Wu, Y., Katona, B.W., O’Dwyer, K., Siegel, D.L., June, C.H., Hua, X.: Bi-specific and split CAR T cells targeting CD13 and TIM3 eradicate acute myeloid leukemia, Blood, Jan 17; [Epub ahead of print], 2020

Choi, H., Kudchodkar, S.B., Reuschel, E.L., Asija, K., Borole, P., Agarwal, S., Van Gorder, L., Reed, C.C., Gulendram, G., Ramos, S., Broderick, K.E., Kim, J.J., Ugen, K.E., Kobinger, G., Siegel, D.L., Weiner, D.B., Muthumani, K.: Synthetic nucleic acid antibody prophylaxis confers rapid and durable protective immunity against Zika virus challenge, Human Vaccines & Immunotherapeutics, Dec 4; [Epub ahead of print], 2019

Nobles, C., Sherrill-Mix, S., Everett, J.K., Reddy, S., Fraietta, J., Porter, D., Frey, N., Gill, S.I., Grupp, S., Maude, S., Siegel, D.L., Levine, B.L. June, C.H., Lacey, S., Melenhorst, J., Bushman, F.: Linking CART19 immunotherapy outcome with genomic modification by vector integration, J Clin Invest, 130:673-685, 2020

Chong, E.A., Levine, B.L., Gruppp, S.A., Davis, M.M., Siegel, D.L., Maude, S.L., Gladney, W.L., Frey, N.V., Porter, D.L., Hwang, W.-T., Chong, E.R., June, C.H., Schuster, S.J. CAR T cell viability release testing and clinical outcomes: is there a lower limit?, Blood, 134:1873-1875, 2019

Garfall, A.L., Dancy, E., Cohen, A.D., Hwang, W.-T., Fraietta, J., Davis, M.M., Levine, B.L., Siegel, D.L., Stradtmauer, E., Vogl, D.T., Waxman, A., Rapoport, A.P., Milone, M., June, C.H., Melenhorst, J.J.: T cell phenotypes associated with effective CAR T cell therapy in post-induction versus relapsed multiple myeloma, Blood Advances, 3:2812-2815, 2019.

Cohen, A., Garfall, A, Stadtmauer, E., Melenhorst, J., Lacey, S., Lancaster, E., Vogl, D., Weiss, B., Dengel, K., Nelson, A. M., Plesa, G., Chen, F., Davis, M., Hwang, W.-T., Young, R., Brogdon, J., Isaacs, R., Pruteanu-Malinici, I., Siegel, D. L., Levine, B., June, C. H., Milone, M.C.: B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma, J Clin Invest, 129:2210-2221, 2019

Fraietta, J.A., Lacey, S.F., Orlando, E.J., Pruteanu-Malinici, I., Gohil, M., Lundh, S., Boesteanu, A.C., Wang, Y., O’Connor, R.S., Hwang, W.-T., Pequignot, E., Ambrose, D.E., Zhang, C., Wilcox, N., Bedoya, F., Dorfmeir, C., Chen, F., Tian, L., Parakandi, H., Gupta, M., Young, R.M., Johnson, F.B., Kulikovskaya, I., Liu, L., Xu, J., Kassim, S.H., Suhoski-Davis, M.M., Levine, B.L., Frey, N.V., Siegel, D.L., Huang, A.C., Wherry, E.J., Bitter, H., Brogdon, J.L., Porter, D.L., June, C.H.,  Melenhorst, J.J.:  Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia, Nature Medicine, 24:563-571, 2018

Villa, C.H., Pan, D.C., Johnston, I., Greineder, C.F., Walsh, L., Hood, E., Cines, D.B., Poncz, M., Siegel, D.L., Muzykantov, V.R.: Biocompatible coupling of therapeutic fusion proteins to human erythrocytes, Blood Advances, 2:165-176, 2018

Carnemolla, R., Villa, C.H., Greineder, C.F., Zaitsev, S., Kowalska, A., Atochin, D.N., Cines, D.B., Siegel, D.L., Esmon, C.T. Muzykantov, V.R.: Targeting thrombomodulin to circulating red blood cells augments its protective effects in models of endotoxemia and ischemia-reperfusion injury, FASEB J., 31:761-770, 2017

Chen, J., Zheng, Q., Hammers, C.M., Ellebrecht, C., Mukherjee, C., Tang, H-Y., Lin, C., Yuan, H-J., Pan, M., Langenhan, J., Komorowski, L., Siegel, D.L., Payne, A.S., Stanley, J.R.: Proteomic analysis of pemphigus autoantibodies indicates a much larger, more diverse, and dynamic repertoire than determined by B-cell genetics, Cell Reports, 18:237-247, 2017

Ostertag, E., Bdeir, K., Kacir, S., Thiboutot, M., Gulendran, G., Yunk, L., Hayes, V., Motto, D., Poncz, M., Zheng, X.L., Cines, D.B., Siegel, D.L.: ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model, Transfusion, 56:1775-1785, 2016

Ostertag, E., Kacir, S., Thiboutot, M., Gulendran, G., Zheng, X.L., Cines, D.B., Siegel, D.L.: ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 1. Structural and functional characterization in vitro, Transfusion, 56:1763-1774, 2016

Fuentes, R.E., Zaytsev, S., Sook Ahn, H., Hayes, V., Kowalska, M.A., Lambert, M.P., Wang, Y., Siegel, D.L., Bougie, D.W., Aster, R.H., Myers, D.D., Stepanova, V., Cines, D.B., Muzykantov, V.R., Poncz, M. : A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation, J Clin Invest, 126:483-494, 2016

Casina, V.C., Hu, W., Mao, J., Lu, R.-N., Hanby, H.A., Pickens, B., Kan, Z., Lim, W.K., Maybe, L., Ostertag, E., Kacir, S., Siegel, D.L., Englander, S.W., Zheng, X.L. : High-resolution epitope mapping by HX MS reveals the pathogenic mechanism and a possible therapy for autoimmune TTP syndrome, PNAS (USA), 112:9620-9625, 2015

Pickens, B., Mao, Y., Li, D., Siegel, D.L., Poncz, M., Cines, D.B., Zheng, X.L.: Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents thrombotic thrombocytopenic purpura in murine models, Blood 125:3326-3334, 2015

Rapoport, A.P., Stadtmauer, E.A., Binder-Scholl, G.K., Goloubeva, O., Vogl, D.Y., Lacey, S., Badros, A.Z., Garfall, A., Weiss, B., Finklestein, J., Kulikovskaya, I., Sinha, S.K., Kronsberg, S., Gupta, M., Bond, S., Melchiori, L., Brewer, J.E., Bennett, A.D., Gerry, A.B., Pumphrey, N.J., Williams, D., Tayton-Martin, H.K., Ribeiro, L., Holdich, T., Yanovich, S., Hardy, N., Yared, J., Kerr, N., Philip, S., Westphal, S., Siegel, D.L., Levine, B.L., Jakobsen, B.K., Kalos, M., June, C.H. : NY-ESO-1-specific TCR-engineered T cells mediate sustained antigen-specific antitumor effects in myeloma, Nature Medicine 21:914-921, 2015

Hammers, C.M., Chen, J., Lin, C., Kacir, S., Siegel, D.L., Payne, A.S., Stanley, J.R.: Persistence of anti-desmoglein 3 IgG+ B-cell clones in pemphigus patients over years, J Invest Dermatol 135:742-749, 2015

Gao, C., Liu, Y., Zhang, H., Zhang, Y., Fukuda, M.N., Palma, A.S., Kozak, R.P., Childs, R.A., Nonaka, M., Li, Z., Siegel, D.L., Hanfland, P., Peehl, D.M., Chai, W., Greene, M.I., Feizi, T.: Carbohydrate sequence of the prostate cancer-associated antigen F77 assigned by a mucin O-glycome designer array, J Biol Chem 289:16462-16477, 2014

Mangalmurti N.S., Friedman J.L., Wang L.C., Stolz D.B., Muthukumaran G., Siegel D.L., Schmidt A.M., Lee J.S., Albelda S.M.: The receptor for advanced glycation end products mediates lung endothelial activation by RBCs, Am J Physiol - Lung Cell Mol Physiol 304:L250-263, 2013

Kouno M., Lin C., Schechter N., Siegel D.L., Stanley J.R.: Targeted delivery of tumor necrosis factor-related apoptosis-inducing ligand to keratinocytes with a pemphigus monoclonal antibody, J Invest Dermatol, 133:2212-2220, 2013

Li Y., Siegel D.L., Scholler N., Kaplan D.E.: Glypican-3-specific scFv isolation and validation for use in hepatocellular carcinoma, BMC Biotechnology, 12:23, 2012

NCBI bibliography