The Second Britton Chance International Symposium on Metabolic Imaging and Spectroscopy
HONORING THE 105th BIRTHDAY OF BRITTON CHANCE
June 11-13, 2018
Rubenstein Auditorium, Smilow Center for Translational Research
Monday, June 11, 2018
7:30 a.m.
Registration
7:50 a.m.
Introductory remarks
Lin Z. Li, Ph.D. University of Pennsylvania
Arjun Yodh, Ph.D. University of Pennsylvania
Welcome remarks
Mitchell Schnall, MD., Ph.D. University of Pennsylvania
SESSION I: CANCER (1)
Chair: Lin Li, Ph.D., University of Pennsylvania
8:00 A.M.
"Metabolic complexity in cancer cells and tumors"
Ralph J. DeBerardinis, M.D., Ph.D.
University of Texas Southwestern Medical Center
8:40 A.M.
"Optical metabolic probes characterize tumor life cycle stages"
Nimmi Rammanujam, Ph.D.
Duke University
9:05 A.M.
"New directions in nonlinear microscopy improve diagnosis of metastatic potential"
Warren Warren, Ph.D.
Duke University
9:30 A.M. – 10:00 A.M.
Coffee Break
SESSION II: METABOLISM AND FUNCTION (1)
Chair: Arjun Yodh, Ph.D., University of Pennsylvania
VIDEOS OF SESSION II: METABOLISM AND FUNCTION & FLASH TALKS
10:00 A.M.
"Coherent spatial frequency domain imaging (c-SFDI) of tissue metabolism"
Bruce Tromberg, Ph.D.
University of California, Irvine
10:25 A.M.
"Advances in noninvasive assessment of organ oxygen consumption in humans by quantitative MRI"
Felix Wehrli, Ph.D.
University of Pennsylvania
10:50 A.M.
"CEST enhanced metabolic imaging at ultrahigh fields"
Ravinder Reddy, Ph.D.
University of Pennsylvania
11:15 A.M. – 11:45 A.M.
Flash talks (I): 90-second summaries of selected posters, introduced by He N. Xu and Jeffrey Cochran
11:45 A.M. – 1:10 P.M.
Lunch break and poster viewing
1:10 P.M.
Grant Workshop: "Pitching your project – a workshop on effective proposals"
Judith Swan, Ph.D.
Princeton University
SESSION III: CANCER (2)
Chair: Rong Zhou, Ph.D., University of Pennsylvania
2:10 P.M.
"Molecular imaging and theranostics of cancer"
Zaver M. Bhujwalla, M.Sc., Ph.D.
Johns Hopkins University School of Medicine
2:35 P.M.
"Predicting cancer aggressiveness by optical redox imaging: feasibility and basis"
He N. Xu, Ph.D.
University of Pennsylvania
3:00 P.M.
"Predicting breast cancer residual cancer burden during early phase neoadjuvant chemotherapy by NIR spectral tomography"
Shudong Jiang, Ph.D.
Dartmouth College
3:15 p.m.
Coffee break
SESSION IV: MUSCLE, PANCREAS, AND OTHER TISSUES
Chair: Shoko Nioka, M.D., Ph.D.
VIDEOS OF SESSION IV: MUSCLE, PANCREAS, AND OTHER TISSUES
3:55 P.M.
"Quantitative imaging of molecular mechanisms underlying glucose-regulated hormone secretion from pancreatic islets"
David W. Piston, Ph.D.
Washington University in St. Louis, Missouri
4:35 P.M.
"Assessing skeletal muscle metabolism using near infrared spectroscopy"
Kevin McCully, Ph.D., FNAK, FACSM
University of Georgia, Athens
5:00 P.M.
"Human brown adipose tissue evaluated by near-infrared time-resolved spectroscopy"
Takafumi Hamaoka, Ph.D.
Tokyo Medical University, Japan
5:15 P.M.
"RunMan legacy: Measuring muscle metabolism 30 years later"
Maria Angela Franceschini, Ph.D.
Massachusetts General Hospital, Harvard Medical School
5:30 P.M.
Short break
VIDEO OF THE BIOSTATISTICS WORKSHOP
5:35 p.m. – 6:25 p.m.
Biostatistics Workshop
Mary Putt, Ph.D.
University of Pennsylvania
"Rigor and reproducibilty: Why are so many studies 'irreproducible'? "
Huaqing Zhao, Ph.D.
Temple University
"Multiple comparisons and false discovery rate using metabolic imaging data"
6:25 P.M. – 7:30 P.M.
Poster viewing and reception
Tuesday, June 12, 2018
7:30 A.M.
Registration
SESSION I: METABOLISM AND FUNCTION (2)
Chair: Joseph Baur, Ph.D., University of Pennsylvania
VIDEOS OF SESSION I: METABOLISM AND FUNCTION
8:00 A.M.
"Towards understanding hydrogen peroxide in redox biology"
Helmut Sies, M.D., Ph.D.
Heinrich Heine University Düsseldorf, Germany
8:40 A.M.
"Spatial and physical properties of mitochondrial oxidative phosphorylation"
Douglas Wallace, Ph.D.
The Children's Hospital of Philadelphia
9:05 A.M.
"Multi-parametric, label-free, high resolution optical imaging for monitoring mitochondrial metabolism and dynamics"
Irene Georgakoudi, Ph.D.
Tufts University
9:30 A.M.
"Imaging metabolic plasticity in breast cancer models via redox enzyme systems"
Krishnan Ramanujan, Ph.D.
Cedars-Sinai Medical Center
9:55 A.M.
"Monitoring diabetic wound metabolism through in vivo multiphoton microscopy"
Kyle P. Quinn, Ph.D.
University of Arkansas
10:10 A.M.
Coffee break
SESSION II: BRAIN
Chair: Maria Angela Franceschini, Ph.D., Massachusetts General Hospital, Harvard Medical School
VIDEOS OF SESSION II: BRAIN & FLASH TALKS
10:40 A.M.
"fNIRS in 2023"
David Boas, Ph.D.
Boston University
11:10 A.M.
"Non-invasive optical hemodynamic monitoring in critically brain-injured patients"
Wesley B. Baker, Ph.D.
The Children's Hospital of Philadelphia and University of Pennsylvania
11:25 A.M.
"Cerebral hemodynamics improve seizure prediction in fNIRS/EEG recordings"
Parikshat Sirpal
Université de Montréal, Canada
11:40 A.M.
"Multifractal hemodynamic fluctuations in the human brain cortex: impact of aging"
Peter Mukli, Ph.D.
Semmelweis University, Hungary
11:55 P.M.
"Real-time color-coded brain cancer mapping for surgical guidance"
Xingde Li, Ph.D.
Johns Hopkins Biomedical Engineering
12:20 P.M.
Flash Talks (II): 90-minute summaries of selected posters, introduced by He N. Xu and Jeffrey Cochran
12:50 P.M. – 2:15 P.M.
Lunch break and poster viewing
SESSION III: NOVEL TECHNIQUES AND APPLICATIONS (1)
Chair: Xingde Li, Ph.D., Johns Hopkins University
VIDEOS OF SESSION III: NOVEL TECHNIQUES AND APPLICATIONS
2:15 P.M.
"Stimulated Raman scattering microscopy: seeing the invisible in biology and medicine"
Sunney Xie, Ph.D.
Harvard University and Peking University, China
2:55 P.M.
"In vivo NAD assay methodology and potential applications for assessing brain NAD+ and NADH contents and redox ratio"
Xiao-hong Zhu, Ph.D.
University of Minnesota
3:20 P.M.
"MitoRACE: in vivo assessment of mitochondrial function using NADH fluorescence"
Thomas B. Willingham, Ph.D.
NHLBI, NIH
3:35 P.M.
"Hyperpolarization chemistry for broadly available metabolic imaging"
Thomas Theis, Ph.D.
Duke University
3:50 P.M.
Coffee break
SESSION IV: CANCER (3)
Chair: Samuel Achilefu, Ph.D., Washington University at St. Louis
VIDEOS OF SESSION IV: CANCER & PANEL DISCUSSION
4:35 P.M.
"Imaging cancer metabolism in patients: FDG, PET, and beyond"
David Mankoff, M.D., Ph.D.
University of Pennsylvania
5:15 P.M.
"Fluorescence molecular imaging of cancer metabolism"
Samuel Achilefu, Ph.D.
Washington University at St. Louis
5:40 P.M.
Early-time breast cancer oxygen saturation predicts response to neoadjuvant chemotherapy
Arjun G. Yodh, Ph.D.
University of Pennsylvania
6:05 P.M.
PANEL: Critical issues in the field of metabolic imaging and spectroscopy
Chair: Bruce Tromberg, Beckman Laser Institute, University of California
Samuel Achilefu, Washington University at St. Louis
Wafik El-Deiry, Fox Chase Cancer Center
Irene Georgakoudi, Tufts University
Joseph LaManna, Case Western Reserve
Ruth Muschel, University of Oxford
7:00 P.M.
Walking break & group photo
7:10 P.M. – 9:00 P.M.
Britton Chance Commemorative Dinner Reception
Penn Museum, 3260 Spruce Street
Ticket required
Speakers
Helen Davies, University of Pennsylvania
Linda Powers, Arizona University
Shoko Nioka, University of Pennsylvania
Wednesday, June 13, 2018
7:30 A.M.
Registration
SESSION I: RADIATION THERAPY AND IMMUNOTHERAPY
Chair: Wafik El-Deiry, MD, PhD, Fox Chase Cancer Center
VIDEOS OF SESSION I: RADIATION THERAPY AND IMMUNOTHERAPY
8:00 A.M.
"Reducing cancer hypoxia to improve radiation therapy"
Ruth J. Muschel, M.D, Ph.D.
University of Oxford, UK
8:40 A.M.
"Assessing tumor oxygen/blood flow for personalization of photodynamic therapy"
Theresa Busch, Ph.D.
University of Pennsylvana
9:05 A.M.
"Radiation therapy mediated molecular imaging"
Brian W. Pogue, Ph.D.
Dartmouth College
9:30 A.M.
Coffee break
SESSION II: METABOLISM AND FUNCTIONS (3) – ISOTOPE METABOLISM
Chair: Felix Wehrli, Ph.D., University of Pennsylvania
VIDEOS OF SESSION III: METABOLISM AND FUNCTIONS - ISOTOPE METABOLISM & FLASH TALKS
10:15 A.M.
"Magnetic resonance spectroscopy studies of the relationship between mitochondrial neuroenergetics and brain function"
Douglas Rothman, Ph.D.
Yale University
10:55 A.M.
"Metabolic flux analysis studies of cancer cells and tumors by 13C-NMR and 13C LC-MS"
Seung-Cheol Lee, Ph.D.
University of Pennsylvania
11:20 A.M.
"Metabolic imaging of the lungs using hyperpolarized 13C-NMR"
Mehrdad Pourfathi
University of Pennsylvania
11:35 A.M.
Flash talks (III): 90-second summaries of selected posters, introduced by He N. Xu and Jeffrey Cochran
12:05 P.M.
Lunch break and poster viewing
SESSION III: NOVEL TECHNIQUES AND APPLICATIONS (2)
Chair: Banu Onaral, Ph.D., Drexel University
VIDEO OF SESSION III: NOVEL TECHNIQUES AND APPLICATIONS
1:35 P.M.
"Metabolic imaging of tumor heterogeneity"
Melissa C. Skala, Ph.D.
University of Wisconsin, Madison
2:00 P.M.
"Translating optical molecular imaging"
Jim Delikatny, Ph.D.
University of Pennsylvania
2:25 P.M.
"Real-time time-resolved fluorescence lifetime measurements and portable point-of-care diagnostic system for bloodborne pathogens"
Linda Powers, Ph.D.
Arizona University
2:50 P.M.
"Total-body metabolism, chemistry and physiology: PET for fetus to adults"
Thomas Budinger, M.D., Ph.D.
University of California, Berkeley
3:15 P.M.
"Early diagnosis of traumatic intracranial hematomas"
Baruch Ben Dor, Ph.D.
Drexel University
3:30 P.M.
Coffee break
SESSION IV: NOVEL TECHNIQUES AND APPLICATIONS (3)
Chair: Brian W. Pogue, Ph.D., Dartmouth College
VIDEOS OF SESSION IV: NOVEL TECHNIQUES AND APPLICATIONS, AWARDS, & CONCLUDING REMARKS
4:00 P.M.
"Temporal metabolic partitioning of the yeast cellular network: the cell is a global scale-invariant (fractal or self-similar), multi-oscillator"
David Lloyd, D.Sc., Ph.D.
Cardiff University, UK
4:25 P.M.
"Engineering freedom of cofactor selection in de novo protein design"
Chris Moser, Ph.D.
University of Pennsylvania
4:50 P.M.
"Mesoscopic functional imaging with fluorescence laminar optical tomography"
Yu Chen, Ph.D.
University of Maryland at College Park
5:15 P.M.
"Conversion of a fluorescent probe to a PET radiotracer"
Robert Mach, Ph.D.
University of Pennsylvania
Concluding Session
5:40 P.M.
Remarks on journal issues
Brian Pogue, Editor-in-Chief, Journal of Biomedical Optics
Raymond Gibson, Editor-in-Chief, Molecular Imaging and Biology
5:45 P.M.
Arjun Yodh, Ph.D.
Poster awards
5:50 P.M.
Lin Z. Li, Ph.D.
Arjun Yodh, Ph.D.
Closing remarks