PUBLICATIONS
TRANSFORM/CONNECT-TBI
2024
Audrey Low, Elizabeth McKiernan; Maria A. Prats-Sedano; Stephen F. Carter; James D. Stefaniak; Li Su; Maria-Eleni Dounavi; Graciela Muniz-Terrera; Natalie Jenkins; Katie Bridgeman; Karen Ritchie; Brian Lawlor; Lorina Naci, PhD; Paresh Malhotra; Clare Mackay; Ivan Koychev; Tony Thayanandan; Vanessa Raymont; Craig W. Ritchie; William Stewart; John T. O’Brien; for the PREVENT Dementia Investigators. Neuroimaging and Clinical Findings in Healthy Middle-Aged Adults With Mild Traumatic Brain Injury in the PREVENT Dementia Study. JAMA Network Open. 2024;7(8):e2426774. doi:10.1001/jamanetworkopen.2024.26774 SUMMARY
Rhonda Mittenzwei, Heather Maioli, Karinn Sytsma, Amanda Kirkland, C. Dirk Keene, Ramon Diaz-Arrastia, Christine Mac Donald, Chiara Maffei, Brian L. Edlow, Amber L. Nolan. Traumatic microhemorhages are not synonomous with axonal injury. MedRxIV. doi: https://doi.org/10.1101/2024.10.21.24315697 SUMMARY
Russell ER, Lyall DM, Mackay DF, Cronin K, Stewart K, MacLean JA, Pell JP, Stewart W. Health and lifestyle factors on dementia risk among former professional soccer players. JAMA Network Open 2024;7(12):e2449742. doi:10.1001/jamanetworkopen.2024.49742 SUMMARY
Ntikas, M., Stewart, W., Letswaart, M., Hunter, A. M., Maas, A. I. R., Menon, D. K., Wilson, L., & the CENTER-TBI participants and investigators (2024). Contrasting Characteristics and Outcomes of Sports-Related and Non–Sports-Related Traumatic Brain Injury. JAMA Network Open, 7(1), Article E2353318. https://doi.org/10.1001/jamanetworkopen.2023.53318. SUMMARY
Rodolphi MS, Strogulski NR, Kopczynski A, Sartor M, Soares G, de Oliveira VG, Vinade L, Dal-Belo C, Portela JV, Geller CA, De Bastiani MA, Justus JS, Portela LOC, Smith DH, Portela LV. Nandrolone Abuse Prior to Head Trauma Mitigates Endoplasmic Reticulum Stress, Mitochondrial Bioenergetic Deficits, and Markers of Neurodegeneration. Mol Neurobiol. 2024 Sep 23. doi: 10.1007/s12035-024-04488-8. Online ahead of print. PMID: 39313656. SUMMARY
Fullerton JL, Hay J, Bryant-Craig C, Atkinson J, Smith DH, Stewart W (2024) Pediatric traumatic brain injury and microvascular blood-brain barrier pathology. JAMANetw Open SUMMARY
2024
Song H, Tomasevich A, Paolini A, Browne KD, Wofford KL, Kelley B, Kantemneni E, Kennedy J, Qiu Y, Schneider ALC, Dolle JP, Cullen DK, Smith DH. Sex differences in the extent of acute axonal pathologies after experimental concussion. Acta Neuropathol. 2024 May 5;147(1):79. doi: 10.1007/s00401-024-02735-9. SUMMARY
Creekmore BC, Watanabe R, Lee EB. Neurodegenerative Disease Tauopathies. Annu Rev Pathol. 2024 Jan 24;19:345-370. doi: 10.1146/annurev-pathmechdis-051222-120750. Epub 2023 Oct 13. SUMMARY
2023
Stewart W, Buckland ME, Abdolmohammadi B, Affleck AJ, Alvarez VE, Gilchrist S, Huber BR, Lee EB, Lyall DM, Nowinski CJ, Russell ER, Stein TD, Suter CM, McKee AC. Risk of chronic traumatic encephalopathy in rugby union is associated with length of playing career. Acta Neuropathol. 2023 Dec;146(6):829-832. doi: 10.1007/s00401-023-02644-3. Epub 2023 Oct 24. SUMMARY
Priemer DS, Perl DP. Neurotrauma: 2023 Update. Free Neuropathol. 2023 Sep 20;4:4-14. doi: 10.17879/freeneuropathology-2023-5076. SUMMARY
Dams-O'Connor K, Seifert AC, Crary JF, Delman BN, Del Bigio MR, Kovacs GG, Lee EB, Nolan AL, Pruyser A, Selmanovic E, Stewart W, Woodoff-Leith E, Folkerth RD. The neuropathology of intimate partner violence. Acta Neuropathol. 2023 Oct 28. doi: 10.1007/s00401-023-02646-1. SUMMARY
Ramos-Llordén G, Park DJ, Kirsch JE, Scholz A, Keil B, Maffei C, Lee HH, Bilgic B, Edlow BL, Mekkaoui C, Yendiki A, Witzel T, Huang SY. Eddy current-induced artifact correction in high b-value ex vivo human brain diffusion MRI with dynamic field monitoring. Magn Reson Med. 2023 Sep 27. doi: 10.1002/mrm.29873. SUMMARY
Song H, Tomasevich A, Acheampong KK, Schaff DL, Shaffer SM, Dolle JP, Johnson VE, Mikytuck B, Lee EB, Nolan A, Keene CD, Weiss SR, Stewart W, Smith DH. Detection of blood-brain barrier disruption in brains of patients with COVID-19, but no evidence of brain penetration by SARS-CoV-2. Acta Neuropathol. 2023 Aug 25. doi: 10.1007/s00401-023-02624-7. SUMMARY
Makdissi M, Critchley ML, Cantu RC, Caron JG, Davis GA, Echemendia RJ, Fremont P, Hayden KA, Herring SA, Hinds SR, Jordan B, Kemp S, McNamee M, Maddocks D, Nagahiro S, Patricios J, Putukian M, Turner M, Sick S, Schneider KJ. When should an athlete retire or discontinue participating in contact or collision sports following sport-related concussion? A systematic review. Br J Sports Med. 2023 Jun;57(12):822-830. doi: 10.1136/bjsports-2023-106815. SUMMARY
Yeates KO, Räisänen AM, Premji Z, Debert CT, Frémont P, Hinds S, Smirl JD, Barlow K, Davis GA, Echemendia RJ, Feddermann-Demont N, Fuller C, Gagnon I, Giza CC, Iverson GL, Makdissi M, Schneider KJ. What tests and measures accurately diagnose persisting post-concussive symptoms in children, adolescents and adults following sport-related concussion? A systematic review. Br J Sports Med. 2023 Jun;57(12):780-788. doi: 10.1136/bjsports-2022-106657.
Silverberg ND, Iverson GL; ACRM Brain Injury Special Interest Group Mild TBI Task Force and the ACRM Mild TBI Definition Expert Consensus Group, ACRM Brain Injury Special Interest Group Mild TBI Task Force members; Cogan A, Dams-O'Connor K, Delmonico R, Graf MJP, Iaccarino MA, Kajankova M, Kamins J, McCulloch KL, McKinney G, Nagele D, Panenka WJ, Rabinowitz AR, Reed N, Wethe JV, Whitehair V; ACRM Mild TBI Diagnostic Criteria Expert Consensus Group; Anderson V, Arciniegas DB, Bayley MT, Bazarian JJ, Bell KR, Broglio SP, Cifu D, Davis GA, Dvorak J, Echemendia RJ, Gioia GA, Giza CC, Hinds SR 2nd, Katz DI, Kurowski BG, Leddy JJ, Sage NL, Lumba-Brown A, Maas AIR, Manley GT, McCrea M, Menon DK, Ponsford J, Putukian M, Suskauer SJ, van der Naalt J, Walker WC, Yeates KO, Zafonte R, Zasler ND, Zemek R. The American Congress of Rehabilitation Medicine Diagnostic Criteria for Mild Traumatic Brain Injury. Arch Phys Med Rehabil. 2023 May 19:S0003-9993(23)00297-6. doi: 10.1016/j.apmr.2023.03.036.
Dams-O'Connor K, Awwad HO, Hoffman SW, Pugh MJ, Johnson V, Keene CD, McGavern L, Mukherjee P, Opanashuk L, Umoh N, Sopko G, Zetterberg H.J. Alzheimer's Disease-Related Dementias Summit 2022: National research priorities for the investigation of post-traumatic brain injury Alzheimer's Disease and Related Dementias. Neurotrauma. 2023 Mar 16. doi: 10.1089/neu.2022.0514.
Lee EB, Kennedy-Dietrich C, Geddes JF, Nicoll JAR, Revesz T, Smith DH,Stewart W. The perils of contact sport: pathologies of diffuse brain swelling and chronic traumatic encephalopathy neuropathologic change in a 23-year-old rugby union player. Acta Neuropathol. 2023 Apr 22. doi: 10.1007/s00401-023-02576-y.
2022
Russell ER, Mackay DF, Lyall D, Stewart K, MacLean JA, Robson J, Pell JP, Stewart W. Neurodegenerative disease risk among former international rugby union players. J Neurol Neurosurg Psychiatry. 2022;93(12):1262-8. Epub 2022/10/05. doi: 10.1136/jnnp-2022-329675. PubMed PMID: 36195436; PMCID: PMC9669247.
Stewart, W., Carson, A (2022). Heading in the right direction. Nat Rev Neurol 18, 573–574.
Roemer SF, Grinberg LT, Crary JF, Seeley WW, McKee AC, Kovacs GG, Beach TG, Duyckaerts C, Ferrer IA, Gelpi E, Lee EB, Revesz T, White CL 3rd, Yoshida M, Pereira FL, Whitney K, Ghayal NB, Dickson DW. Rainwater Charitable Foundation criteria for the neuropathologic diagnosis of progressive supranuclear palsy. Acta Neuropathol. 2022 Oct;144(4):603-614. doi: 10.1007/s00401-022-02479-4.
Song H, McEwan PP, Ameen-Ali KE, Tomasevich A, Kennedy-Dietrich C, Palma A, Arroyo EJ, Dolle JP, Johnson VE, Stewart W, Smith DH. Concussion leads to widespread axonal sodium channel loss and disruption of the node of Ranvier. Acta Neuropathol. 2022 Sep 15. doi: 10.1007/s00401-022-02498-1
John F. Crary. Neurodegeneration: 2022 update. Free Neuropathology 3:13 (2022). https://doi.org/10.17879/freeneuropathology-2022-3866
Agrawal S, Leurgans SE, James BD, Barnes LL, Mehta RI, Dams-O'Connor K, Mez J, Bennett DA, Schneider JA. Association of Traumatic Brain Injury With and Without Loss of Consciousness With Neuropathologic Outcomes in Community-Dwelling Older Persons. JAMA Netw Open. 2022;5(4):e229311. Epub 2022/04/28. doi: 10.1001/jamanetworkopen.2022.9311. PubMed PMID: 35476062; PMCID: PMC9047640.
Ameen-Ali KE, Bretzin A, Lee EB, Folkerth R, Hazrati LN, Iacono D, Keene CD, Kofler J, Kovacs GG, Nolan A, Perl DP, Priemer DS, Smith DH, Wiebe DJ, Stewart W, Investigators C-T. Detection of astrocytic tau pathology facilitates recognition of chronic traumatic encephalopathy neuropathologic change. Acta Neuropathol Commun. 2022;10(1):50. Epub 2022/04/13. doi: 10.1186/s40478-022-01353-4. PubMed PMID: 35410438; PMCID: PMC8996534.
2021
Burke J, Gugger J, Ding K, Kim JA, Foreman B, Yue JK, Puccio AM, Yuh EL, Sun X, Rabinowitz M, Vassar MJ, Taylor SR, Winkler EA, Deng H, McCrea M, Stein MB, Robertson CS, Levin HS, Dikmen S, Temkin NR, Barber J, Giacino JT, Mukherjee P, Wang KKW, Okonkwo DO, Markowitz AJ, Jain S, Lowenstein D, Manley GT, Diaz-Arrastia R, Investigators T-T, Badjatia N, Duhaime AC, Feeser VR, Gaudette E, Gopinath S, Keene CD, Korley FK, Madden C, Merchant R, Schnyer D, Zafonte R. Association of Posttraumatic Epilepsy With 1-Year Outcomes After Traumatic Brain Injury. JAMA Netw Open. 2021;4(12):e2140191. Epub 2021/12/30. doi: 10.1001/jamanetworkopen.2021.40191. PubMed PMID: 34964854; PMCID: PMC8717106.
Brett BL, Gardner RC, Godbout J, Dams-O'Connor K, Keene CD. Traumatic Brain Injury and Risk of Neurodegenerative Disorder. Biol Psychiatry. 2022;91(5):498-507. Epub 2021/08/09. doi: 10.1016/j.biopsych.2021.05.025. PubMed PMID: 34364650; PMCID: PMC8636548.
Smith DH, Kochanek PM, Rosi S, Meyer R, Ferland-Beckham C, Prager EM, Ahlers ST, Crawford F. Roadmap for Advancing Pre-Clinical Science in Traumatic Brain Injury. J Neurotrauma. 2021;38(23):3204-21. Epub 2021/07/03. doi: 10.1089/neu.2021.0094. PubMed PMID: 34210174; PMCID: PMC8820284.
Creekmore BC, Chang YW, Lee EB. The Cryo-EM Effect: Structural Biology of Neurodegenerative Disease Aggregates. J Neuropathol Exp Neurol. 2021;80(6):514-29. Epub 2021/05/11. doi: 10.1093/jnen/nlab039. PubMed PMID: 33970243; PMCID: PMC8177849.
Kim B, Mikytuck B, Suh E, Gibbons GS, Van Deerlin VM, Vaishnavi SN, Spindler MA, Massimo L, Grossman M, Trojanowski JQ, Irwin DJ, Lee EB. Tau immunotherapy is associated with glial responses in FTLD-tau. Acta Neuropathol. 2021. Epub 2021/05/06. doi: 10.1007/s00401-021-02318-y. PubMed PMID: 33950293.
Creekmore BC, Chang YW, Lee EB. The Cryo-EM Effect: Structural Biology of Neurodegenerative Disease Proteostasis Factors. J Neuropathol Exp Neurol. 2021;80(6):494-513. Epub 2021/04/17. doi: 10.1093/jnen/nlab029. PubMed PMID: 33860329; PMCID: PMC8177850.
Russell ER, Mackay DF, Stewart K, MacLean JA, Pell JP, Stewart W. Association of Field Position and Career Length With Risk of Neurodegenerative Disease in Male Former Professional Soccer Players. JAMA Neurol. 2021;78(9):1057-63. Epub 2021/08/03. doi: 10.1001/jamaneurol.2021.2403. PubMed PMID: 34338724; PMCID: PMC8329793.
Postupna N, Rose SE, Gibbons LE, Coleman NM, Hellstern LL, Ritchie K, Wilson AM, Cudaback E, Li X, Melief EJ, Beller AE, Miller JA, Nolan AL, Marshall DA, Walker R, Montine TJ, Larson EB, Crane PK, Ellenbogen RG, Lein ES, Dams-O'Connor K, Keene CD. The Delayed Neuropathological Consequences of Traumatic Brain Injury in a Community-Based Sample. Front Neurol. 2021;12:624696. Epub 2021/04/03. doi: 10.3389/fneur.2021.624696. PubMed PMID: 33796061; PMCID: PMC8008107.
Katz DI, Bernick C, Dodick DW, Mez J, Mariani ML, Adler CH, Alosco ML, Balcer LJ, Banks SJ, Barr WB, Brody DL, Cantu RC, Dams-O'Connor K, Geda YE, Jordan BD, McAllister TW, Peskind ER, Petersen RC, Wethe JV, Zafonte RD, Foley EM, Babcock DJ, Koroshetz WJ, Tripodis Y, McKee AC, Shenton ME, Cummings JL, Reiman EM, Stern RA. National Institute of Neurological Disorders and Stroke Consensus Diagnostic Criteria for Traumatic Encephalopathy Syndrome. Neurology. 2021;96(18):848-63. Epub 2021/03/17. doi: 10.1212/WNL.0000000000011850. PubMed PMID: 33722990; PMCID: PMC8166432.
Iacono D, Raiciulescu S, Olsen C, Perl DP. Traumatic Brain Injury Exposure Lowers Age of Cognitive Decline in AD and Non-AD Conditions. Frontiers in Neurology. 2021;12(764). doi: 10.3389/fneur.2021.573401.
Russell ER, McCabe T, Stewart W. Not all adverse health outcomes in former contact sports athletes are concussion related. J Neurol Neurosurg Psychiatry. 2021. Epub 2020 November 15. doi: 10.1136/jnnp-2020-324672. PubMed PMID: 33188135.
Stewart, W. Sport associated dementia: Prevention remains the only cure. British Medical Journal, 2021. 372, 168. doi: 10.1136/bmj.n168. PubMed PMID:33478970.
Smith DH, Dolle JP, Ameen-Ali KE, Bretzin A, Cortes E, Crary JF, Dams-O'Connor K, Diaz-Arrastia R, Edlow BL, Folkerth R, Hazrati LN, Hinds SR, Iacono D, Johnson VE, Keene CD, Kofler J, Kovacs GG, Lee EB, Manley G, Meaney D, Montine T, Okonkwo DO, Perl DP, Trojanowski JQ, Wiebe DJ, Yaffe K, McCabe T, Stewart W. COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI). Acta Neuropathol Commun. 2021;9(1):32. Epub 2021/03/03. doi: 10.1186/s40478-021-01122-9. PubMed PMID: 33648593.
2020
Arena JD, Johnson VE, Lee EB, Gibbons GS, Smith DH, Trojanowski JQ, Stewart W. Astroglial tau pathology alone preferentially concentrates at sulcal depths in chronic traumatic encephalopathy neuropathologic change. Brain Communications, , (2)2 fcaa210, Epub 2020 December 03.
Schneider ALC, Dams-O'Connor K. Demographic differences in the association of traumatic brain injury with dementia: Race matters. Neurology. 2020;95(13):561-2. Epub 2020/09/06. doi: 10.1212/WNL.0000000000010675. PubMed PMID: 32887770.
Smith DH, Stewart W. 'Concussion' is not a true diagnosis. Nat Rev Neurol. 2020;16(9):457-8. Epub 2020 July 11. doi: 10.1038/s41582-020-0382-y. PubMed PMID: 32647140.
Arena JD, Smith DH, Lee EB, Gibbons GS, Irwin DJ, Robinson JL, Lee VM, Trojanowski JQ, Stewart W, Johnson VE. Tau immunophenotypes in chronic traumatic encephalopathy recapitulate those of ageing and Alzheimer's disease. Brain. 2020;143(5):1572-87. Epub 2020 May 12. doi: 10.1093/brain/awaa071. PubMed PMID: 32390044; PMCID: PMC7241956.