Perelman School of Medicine at the University of Pennsylvania

CorLab | Advanced Cardiovascular Imaging Lab

Header Image

3D printed mitral valves, flow dynamics in valvular disease, and T1rho MRI

CorLab | Advanced Cardiovascular Imaging Lab

Who We Are

We are a research group in the Department of Radiology at the University of Pennsylvania and our main interests are the development of new imaging technologies for cardiovascular disease.

Principal Investigator: Walter RT Witschey, PhD

Our Research

The prevalence of heart failure continues to increase as the adult population ages, so understanding the role of hypertension and obesity to the development of heart failure is a number one priority in cardiovascular medicine.

To disentangle the relationships between the multiple organ systems implicated in heart failure, non-invasively in humans, and to understand how differences emerge in cardiovascular disease, it’s necessary to have methods that can probe disease holistically, at multiple locations, and to measure the relevant quantities at each organ, such as arterial flow, pressure and contractility.

It’s not enough simply to know these parameters, but also to measure their concurrent activity to understand their dynamic and integrated response. Major breakthroughs for heart failure treatment will arise from uncovering these complex relationships in patients.

The main focus of our group is the development of effective ways to non-invasively characterize the relationships between brain, heart and arteries in cardiovascular disease and the progression to heart failure.

To elucidate the pathogenesis of heart failure, our group develops magnetic resonance imaging (MRI) approaches that establish relationships between the different organs implicated in heart disease. Our major areas of interest are the determinants of cardiac contractile function, arrhythmias, and autonomic nervous system control of the heart.

Our group uses a multidisciplinary approach, integrating techniques from RF and electromagnetic engineering, computer vision and nuclear spin physics with a special emphasis on the real-time and nonlinear dynamics of the cardiovascular system.

Our work is supported by the National Institutes of Health, National Heart Lung and Blood Institute (R00 HL108157), the McCabe foundation and the Institute for Translational Medicine and Therapeutics at the University of Pennsylvania.