Perelman School of Medicine at the University of Pennsylvania

CorLab | Advanced Cardiovascular Imaging Lab



Wang J, Zhao H, Wang Y, Herrmann HC, Witschey WR, Han Y. Native T1 and T2 mapping by cardiovascular magnetic resonance imaging in pressure overloaded left and right heart diseases. Journal of Thoracic Disease. 2018.

Al-Badri A, Hashmath Z, Oldland GH, Miller R, Javaid K, Syed AA, Ansari B, Gaddam S, Witschey WR, Akers SR, Chirinos JA. Poor Glycemic Control Is Associated With Increased Extracellular Volume Fraction in Diabetes. Diabetes Care. 2018.

Hsu JC, Naha PC, Lau KC, Chhour P, Hastings R, Moon BF, Stein JM, Witschey W, McDonald ES, Maidment A, Cormode D. An all-in-one nanoparticle (AION) contrast agent for breast cancer screening with DEM-CT-MRI-NIRF imaging. Nanoscale. 2018.



Muser D, Liang JJ, Witschey WR, Pathak RK, Castro S, Magnani S, Zado ES, Garcia FC, Desjardins B, Callans DJ, Frankel DS, Marchlinski FE, Santangeli P. Ventricular arrhythmias associated with left ventricular noncompaction: Electrophysiologic characteristics, mapping, and ablation. Heart Rhythm. 2017 Feb 28. 14(2):166-175.

Stoffers RH, Madden M, Shahid M, Contijoch F, Solomon J, Pilla JJ, Gorman JH, Gorman RC, Witschey WR. Assessment of myocardial injury after reperfused infarction by T1ρ cardiovascular magnetic resonance. JCMR. 2017 Feb 15. 19(1):17.

McCormick ME, Manduchi E, Witschey WR, Gorman RC, Gorman JH, Jiang Y-Z, Stoeckert CJ, Barker AJ, Yoon S, Markl M, and Davies PF. Spatial phenotyping of the endocardial endothelium as a function of intracardiac hemodynamic shear stress. Journal of Biomechanics. 2017 Jan 4. 50:11-19.



Contijoch FJ, Witschey WR, McGarvey J, Lee ME, Gorman J, Gorman RC, and Pilla JJ. Slice-by-Slice Pressure-Volume Loop Analysis Demonstrates Native Differences in Regional Cardiac Contractility and Response to Inotropic Agents. Ann. Thor. Surg. 2016 Sep 30.

Muser D, Liang JJ, Witschey WR, Pathak RK, Castro S, Magnani S, Zado ES, Garcia FC, Desjardins B, Callans DJ, Frankel DS, Marchlinski FE, Santangeli P. Ventricular Arrhythmias Associated with Left Ventricular Non Compaction: Electrophysiological Characteristics, Mapping, and Ablation. Heart Rhythm. 2016 Nov 23. doi: 10.1016/j.hrthm.2016.11.014.

McCormick ME, Manduchi E, Witschey WR, Gorman RC, Gorman JH 3rd, Jiang YZ, Stoeckert CJ Jr, Barker AJ, Yoon S, Markl M, Davies PF. Spatial phenotyping of the endocardial endothelium as a function of intracardiac hemodynamic shear stress. J Biomech. 2016 Nov 16. pii: S0021-9290(16)31186-1. doi: 10.1016/j.jbiomech.2016.11.018. [Epub ahead of print] PubMed PMID: 27916240.

Rodell CB, Lee ME, Wang H, Takebayashi S, Takayama T, Kawamura T, Arkles JS, Dusaj NN, Dorsey SM, Witschey WR, Pilla JJ, Gorman JH 3rd, Wenk JF, Burdick JA, Gorman RC. Injectable Shear-Thinning Hydrogels for Minimally Invasive Delivery to InfarctedMyocardium to Limit Left Ventricular Remodeling. Circ Cardiovasc Interv. 2016 Oct;9(10). pii: e004058.

Contijoch F, Iyer SK, Pilla JJ, Yushkevich P, Gorman JH 3rd, Gorman RC, Litt H, Han Y, Witschey WR. Self-gated MRI of multiple beat morphologies in the presence of arrhythmias. Mag. Res. Med. 2016. doi:10.1002/mrm.26381

Contijoch FJ, Witschey WR, McGarvey J, Lee ME, Gorman J 3rd, Gorman RC, Pilla JJ. Slice-by-Slice Pressure-Volume Loop Analysis Demonstrates Native Differences in Regional Cardiac Contractility and Response to Inotropic Agents. Ann Thorac Surg. 2016 Sep;102(3):796-802. doi: 10.1016/j.athoracsur.2016.02.055.

McCormick ME, Manduchi E, Witschey WR, Gorman RC, Gorman JH 3rd, Jiang YZ, Stoeckert CJ Jr, Barker AJ, Markl M, Davies PF. Integrated Regional Cardiac Hemodynamic Imaging and RNA Sequencing Reveal Corresponding Heterogeneity of Ventricular Wall Shear Stress and Endocardial Transcriptome. J Am Heart Assoc. 2016 Apr 18;5(4):e003170. doi: 10.1161/JAHA.115.003170.

Contijoch F, Rogers K, Rears H, Shahid M, Kellman P, Gorman J 3rd, Gorman RC, Yushkevich P, Zado ES, Supple GE, Marchlinski FE, Witschey WR, Han Y. Quantification of Left Ventricular Function With Premature Ventricular Complexes Reveals Variable Hemodynamics. Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e003520. doi: 10.1161/CIRCEP.115.003520.

Berisha S, Han J, Shahid M, Han Y, Witschey WR. Measurement of Myocardial T1ρ with a Motion Corrected, Parametric Mapping Sequence in Humans. PLoS One. 2016 Mar 22;11(3):e0151144. doi: 10.1371/journal.pone.0151144.



Witschey WR, Zhang D, Contijoch F, McGarvey JR, Lee M, Takebayashi S, Aoki C, Han Y, Han J, Barker A, Pilla JJ, Gorman RC, Gorman JH 3rd. The influence of mitral annuloplasty on left ventricular flow dynamics. Ann Thorac Surg. 2015. PMID: 25975941.

Pilla JJ, Koomalsingh KJ, McGarvey JR, Witschey WR, Dougherty L, Gorman JH 3rd, Gorman RC. Regional myocardial three-dimensional principal strains during postinfarction remodeling. Ann Thorac Surg. 2015. PMID: 25620591.

Dorsey SM, Haris M, Singh A, Witschey WR, Rodell CB, Kogan F, Reddy R, Burdick JA. Visualization of injectable hydrogels using chemical exchange saturation transfer MRI. ACS Biomater Sci Eng. 2015. 1(4). p. 227-37. PMID: 25620591.



McGarvey JR, Kondo N, Witschey WR, Takebe M, Aoki C, Burdick JA, Spinale FG, Gorman JH 3rd, Pilla JJ, Gorman RC. Injectable microsphere gel progressively improves global ventricular function, regional contractile strain, and mitral regurgitation after myocardial infarction. Ann Thorac Surg. 2014. PMID: 25524397.

Naha PC, Zaki AA, Hecht E, Chorny M, Chhour P, Blankemeyer E, Yates DM, Witschey WR, Litt HI, Tsourkas A, Cormode DP. Dextran coated bismuth-iron oxide nanohybrid contrast agents for computed tomography and magnetic resonance imaging. J Mater Chem B Mater Biol Med. 2014. PMID: 25485115.

Chhour P, Gallo N, Cheheltani R, Williams D, Al-Zaki A, Paik T, Nichol JL, Tian Z, Naha PC, Witschey WR, Allcock HR, Murray CB, Tsourkas A, Cormode DP. Nanodisco balls: Control over Surface versus Core Loading of Diagnostically Active Nanocrystals into Polymer Nanoparticles. ACS Nano. 2014. PMID: 25188401.

Witschey WR, Pouch AM, McGarvey JR, Ikeuchi K, Contijoch F, Levack MM, Yushkevick PA, Sehgal CM, Jackson BM, Gorman RC, Gorman JH 3rd. Three-dimensional ultrasound-derived physical mitral valve modeling. Ann Thorac Surg. 2014. 98(2):691-4. PMID: 25087790.

Schultz G, Gallichan D, Weber H, Witschey WR, Honal M, Hennig J, Zaitsev M. Image reconstruction in k-space from MR data encoded with ambiguous gradient fields. Magn Reson Med. 2014. PMID: 24777559.

Han Y, Liimatainen T, Gorman RC, Witschey WR. Assessing cardiovascular disease using T1rho MRI. Curr Cardiovasc Imaging Rep. 2014. PMID: 24688628.

Witschey WR, Contijoch F, McGarvey JR, Ferrari VA, Hansen MS, Lee ME, Takebayashi S, Aoki C, Chirinos JA, Yushkevich PA, Gorman JH 3rd, Pilla JJ, Gorman RC. Real-time magnetic resonance imaging technique for determining left ventricle pressure-volume loops. Ann Thorac Surg. 2014. PMID: 24629301.

Haris M, Singh A, Cai K, Kogan F, McGarvey J, DeBrosse C, Zsido GA, Witschey WRT, Koomalsingh K, Pilla JJ, Chirinos JA, Ferrari VA, Gorman JH, Hariharan H, Gorman RC, Reddy R. A technique for in vivo mapping of myocardial creatine kinase metabolism. Nature Med. 2014. 20(2):209-214. PMID: 24412924.



McGarvey JR, Kondo N, Takebe M, Koomalsingh KJ, Witschey WR, Barker AJ, Markl M, Takebayashi S, Shimaoka T, Gorman JH 3rd, Gorman RC, Pilla JJ. Directed epicardial assistance in ischemic cardiomyopathy: Flow and function using cardiac magnetic resonance imaging. Ann Thorac Surg. 2013. 96(2):577-85. PMID: 23810178.

Witschey WRT, Littin S, Cocosco CA, Gallichan D, Schultz G, Weber H, Welz A, Hennig J, Zaitsev M. Stages: Sub-Fourier Dynamic Shim Updating Using Nonlinear Magnetic Field Phase Preparation. Magn Reson Med. 2014. 71(1):57-66. PMID: 23440677

Welz AM, Testud F, Cocosco CA, Dewdney A, Lehr H, Gallichan D, Jia F, Post H, Schmitt H, Schultz G, Weber H, Witschey WRT, Korvink J, Hennig J, Zaitsev M. Development and characterization of an unshielded PatLoc gradient coil for human head imaging. Concepts Magn. Reson. 2013.



Koomalsingh KJ, Witschey WR, McGarvey JR, Shuto T, Kondo N, Xu C, Jackson BM, Gorman JH 3rd, Gorman RC, Pilla JJ. Optimized local infarct restraint improves left ventricular function and limits remodeling. Ann Thorac Surg. 2012. 95(1):155-62. PMID: 23146279.

Weber H, Gallichan D, Schultz G, Cocosco CA, Littin S, Reichardt W, Welz A, Witschey W, Hennig J, Zaitsev M. Excitation and geometrically matched local encoding of curved slices. 2012. 69(5):1317-25. PMID: 22711656.

Witschey WR, Zsido GA, Koomalsingh K, Kondo N, Minakawa M, Shuto T, McGarvey JR, Levack MA, Contijoch F, Pilla JJ, Gorman JH, Gorman RC. In vivo chronic myocardial infarction characterization by spin locked cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2012. 15;14(1):37. PMID: 22704222

Fenty MC, Dodge GR, Kassey VB, Witschey WR, Borthakur A, Reddy R. Quantitative cartilage degeneration associated with spontaneous osteoarthritis in a guinea pig model. J Magn Reson Imaging. 2012. April;35(4):891-8. PMID: 22128105.

Witschey WR, Cocosco CA, Gallichan D, Schultz G, Weber H, Welz A, Hennig J, Zaitsev M. Localization by nonlinear phase preparation and k-space trajectory design. Magn Reson Med (2012) Jun;67(6)1620-32. PMID: 22127679.



Schultz, G, Weber H, Gallichan D, Witschey W, Welz A, Cocosco C, Hennig J, Zaitsev M. Radial imaging with multipolar magnetic encoding fields. IEEE Trans Med Imag. 2011 Dec; 30(12):2134-45. PMID: 21843982.

Mosher TJ, Zhang Z, Reddy R, Boudhar S, Milestone BN, Morrison WB, Kwoh CK, Eckstein F, Witschey WR, Borthakur A. Knee articular cartilage damage in osteoarthritis: analysis of MR image biomarker reproducibility in ACRIN-PA 4001 Multicenter Trial. Radiology (2011). Mar;258(3):832-842. PMID: 21212364.



Witschey WR, Pilla JJ, Ferrari G, Koomalsingh K, Haris M, Hinmon R, Zsido G, Gorman JH 3rd, Gorman RC, Reddy R. Rotating frame spin lattice relaxation in a swine model of chronic, left ventricular myocardial infarction. Magn Reson Med. 2010. Nov;64(5):1453-60. PMID: 20677236.

Wang C, Witschey W, Elliott MA, Borthakur A, Reddy R. Measurement of intervertebral disc pressure with T1ρ MRI. Magn Reson Med. (2010) Dec;64(6):1721-7. PMID: 20677234.

Wang C, Witschey W, Goldberg A, Elliott M, Borthakur A, Reddy R. Magnetization transfer ratio mapping of intervertebral disc degeneration. Magn Reson Med (2010). Nov;64(5):1520-8. PMID: 20677229.

Witschey WRT, Bortakur A, Fenty M, Kneeland BJ, Lonner JH, McArdle EL, Sochor M, Reddy R. T1ρ MRI quantification of arthroscopically confirmed cartilage degeneration. Magn Reson Med. 2010. 63(5):1376-82. PMID: 20432308.

Wang C, Mcardle E, Fenty M, Witschey WRT, Elliott M, Sochor M, Reddy R, Borthakur A. Validation of sodium magnetic resonance imaging of the intervertebral disc. Spine (2010) 35(5):505-10. PMID: 20147881.

Witschey WRT, Borthakur A, Elliott MA, Reddy R. Spin Locked Balanced Steady-State Free Precession Imaging. Magnetic Resonance in Medicine. 2009. 62(4):993-1001. PMID: 19672947.

Mellon EA, Pilkinton DT, Clark CM, Elliott MA, Witschey 2nd WR, Borthakur A, Reddy R. Sodium MR Imaging Detection of Mild Alzheimer Disease: Preliminary Study. Am J Neuroradiol. 2009. 30(5):978-84. PMID: 19213826.

Mellon EA, Beesam RS, Baumgaurdner JE, Borthakur A, Witschey WR, Reddy R. Estimation of the regional cerebral metabolic rate of oxygen consumption with proton detected O-17 MRI during precision O-17(2) inhalation in swine. J Neurosci Methods. 2009. 179(1):29-39. PMID: 19429508.

Mellon EA, Beesam RS, Kasam M, Baumgardner JE, Borthakur A, Witschey WR, Reddy R. Single Shot T1 magnetic resonance imaging of metabolically generated water in vivo. Oxygen Transport in Tissue. 2009. 645:279-86. PMID: 19227483.

Witschey WRT, Borthakur A, Elliott MA, Wang C, Reddy R. Rapid 3D T1rho-prepared balanced gradient echo for rapid 3D T1rho MRI. Journal of Magnetic Resonance Imaging. 2008. 28(3):744-54. PMID: 18777535.

Witschey WRT, Borthakur A, Elliott MA, Mellon E, Niyogi S, Wallman DJ, Wang C, Reddy R. Artifacts in T1ρ-weighted Imaging: Compensation for B1 and B0 Field Imperfections. J Magn Reson. 2007. 186(1):75-85. PMID: 17291799.

Witschey WRT, Borthakur A, Elliott MA, Mellon E, Niyogi S, Wang C, Reddy R. Compensation for Spin-Lock Artifacts Using an Off-Resonance Rotary Echo in T1ρoff-weighted Imaging. Magn Reson Med. 2007. 57(1):2-7. PMID: 17191245.

Wang C, Auerbach JD, Witschey WRT, Balderston RA, Reddy R, Borthakur A. Advances in magnetic resonance imaging for the assessment of degenerative disc disease of the lumbar spine. Seminars in Spine Surgery. 2007. 19(2):65-71. PMID: 18037984.