Shefali Setia Verma
Assistant Professor of Biostatistics and Epidemiology
Perelman School of Medicine at the University of Pennsylvania
Assistant Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Shefali.SetiaVerma@pennmedicine.upenn.edu
Richards Medical Research Laboratories, D202
3700 Hamilton Walk
Philadelphia, PA 19104
Specialty Division
Diagnostic Innovation
Graduate Groups
Cell and Molecular Biology
Genomics and Computational Biology
Education
B.Tech (Biotechnology), Jaipur National University, 2008
MS (Bioinformatics), New Jersey Institute of Technology, 2011
PhD (Bioinformatics and Genomics), Penn State University, 2018
Research
Linking phenotypes in women’s health to genomics
Selected Publications
A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma
Verma SS, Gudiseva HV, Chavali VRM, Salowe RJ, Bradford Y, Guare L, Lucas A, Collins DW, Vrathasha V, Nair RM, Rathi S, Zhao B, He J, Lee R, Zenebe-Gete S, Bowman AS, McHugh CP, Zody MC, Pistilli M, Khachatryan N, Daniel E, Murphy W, Henderer J; Regeneron Genetics Center; Kinzy TG, Iyengar SK, Peachey NS; VA Million Veteran Program; Taylor KD, Guo X, Chen YI, Zangwill L, Girkin C, Ayyagari R, Liebmann J, Chuka-Okosa CM, Williams SE, Akafo S, Budenz DL, Olawoye OO, Ramsay M, Ashaye A, Akpa OM, Aung T, Wiggs JL, Ross AG, Cui QN, Addis V, Lehman A, Miller-Ellis E, Sankar PS, Williams SM, Ying GS, Cooke Bailey J, Rotter JI, Weinreb R, Khor CC, Hauser MA, Ritchie MD, O’Brien JM. Cell 187(2):464-480.e10, Jan 2024. doi: 10.1016/j.cell.2023.12.006. PMID: 38242088.
Polygenic risk scores for cardiometabolic traits demonstrate importance of ancestry for predictive precision medicine
Kember RL, Verma SS, Verma A, Xiao B, Lucas A, Kripke CM, Judy R, Chen J, Damrauer SM, Rader DJ, Ritchie MD. Pac Symp Biocomput 29:611-626, 2024. PMID: 38160310.
Uncovering myocardial infarction genetic signatures using GWAS exploration in Saudi and European cohorts
Al-Ali AK, Al-Rubaish AM, Alali RA, Almansori MS, Al-Jumaan MA, Alshehri AM, Al-Madan MS, Vatte C, Cherlin T, Young S, Verma SS, Morahan G, Koeleman BPC, Keating BJ. Sci Rep 13(1):21866, Dec 2023. doi: 10.1038/s41598-023-49105-1. PMID: 38072966; PMCID: PMC10711020.
Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target
Roychowdhury T, Klarin D, Levin MG, Spin JM, Rhee YH, Deng A, Headley CA, Tsao NL, Gellatly C, Zuber V, Shen F, Hornsby WE, Laursen IH, Verma SS, Locke AE, Einarsson G, Thorleifsson G, Graham SE, et al. Nat Genet 55(11):1831-1842, Nov 2023. doi: 10.1038/s41588-023-01510-y. Epub 2023 Oct 16. PMID: 37845353; PMCID: PMC10632148.
Quantitative traits associated with primary open-angle glaucoma in African ancestry individuals
Verma SS, Gudiseva HV, Chavali, VRM, Bradford Y, Salowe R, He J, Lee R, Zenebe-Gete S, Daniel E, Ying GS, Miller-Ellis EG. Investigative Ophthalmology & Visual Science, New Orleans, LO – Poster Presentation 63(7): 4013 – A0355, 2023.
Gene Interactions in Human Disease Studies-Evidence Is Mounting
Singhal P, Verma SS, Ritchie MD. Annu Rev Biomed Data Sci 6:377-395, Aug 2023. doi: 10.1146/annurev-biodatasci-102022-120818. Epub 2023 May 17. PMID: 37196359.
Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program
Klarin D, Devineni P, Sendamarai AK, Angueira AR, Graham SE, Shen YH, Levin MG, Pirruccello JP, Surakka I, Karnam PR, Roychowdhury T, Li Y, Wang M, Aragam KG, Paruchuri K, Zuber V, Shakt GE, Tsao NL, Judy RL, Vy HMT, Verma SS, Rader DJ, Do R, Bavaria JE, Nadkarni GN, Ritchie MD; VA Million Veteran Program; Burgess S, Guo DC, Ellinor PT, LeMaire SA, Milewicz DM, Willer CJ, Natarajan P, Tsao PS, Pyarajan S, Damrauer SM. Nat Genet 55(7):1106-1115, Jul 2023. doi: 10.1038/s41588-023-01420-z. Epub 2023 Jun 12. PMID: 37308786; PMCID: PMC10335930.
Leveraging electronic health record data for endometriosis research
Penrod N, Okeh C, Velez Edwards DR, Barnhart K, Senapati S, Verma SS. Front Digit Health 5:1150687, Jun 2023. doi: 10.3389/fdgth.2023.1150687. PMID: 37342866; PMCID: PMC10278662.
How to Run the Pharmacogenomics Clinical Annotation Tool (PharmCAT)
Li B, Sangkuhl K, Keat K, Whaley RM, Woon M, Verma S, Dudek S, Tuteja S, Verma A, Whirl-Carrillo M, Ritchie MD, Klein TE. Clin Pharmacol Ther 113(5):1036-1047, May 2023. doi: 10.1002/cpt.2790. Epub 2022 Dec 23. PMID: 36350094; PMCID: PMC10121724.
Genome-Wide Association Study of Breast Density Among Women of African Ancestry
Verma SS, Guare L, Ehsan S, Gastounioti A, Scales G, Ritchie MD, Kontos D, McCarthy AM, Penn Medicine Biobank. Cancers (Basel) 15(10):2776, May 2023. doi: 10.3390/cancers15102776. PMID: 37345113; PMCID: PMC10216271.