2021

  • Gautreau AM, Fregoso FE, Simanov G, Dominguez R (2021) Nucleation, Stabilization and Disassembly of Branched Actin Networks. Trends Cell Biol. DOI: https://doi.org/10.1016/j.tcb.2021.10.006

  • Fregoso FE, Van Eeuwen T, Simanov G, Rebowski G, Boczkowska M, Zimmet A, Gautreau AM, Dominguez R (2021) Molecular mechanism of Arp2/3 complex inhibition by Arpin. bioRxiv, DOI: https://doi.org/10.1101/2021.10.30.466598

  • Carman PJ, Barrie KR, Dominguez R (2021) Novel human cell expression method reveals the role and prevalence of posttranslational modification in non-muscle tropomyosins. J Biol Chem 297: 101154. DOI: 10.1016/j.jbc.2021.101154

  • Cason SE, Carman PJ , Van Duyne C, Goldsmith J, Dominguez R, Holzbaur ELF (2021) Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway J Cell Biol, 220(7):e202010179, DOI: https://doi.org/10.1083/jcb.202010179

  • Baker RW, Reimer JM, Carman PJ, Turegun B, Arakawa T, Dominguez R, Leschziner AE (2021) Structural insights into assembly and function of the RSC chromatin remodeling complex. Nature Struct Mol Biol, 28, DOI: https://doi.org/10.1038/s41594-020-00528-8

2020

  • Lee IG, Cason SE, Alqassim SS, Holzbaur ELF, Dominguez R (2020) A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner. Nat Commun, 11:5695. DOI: https://doi.org/10.1038/s41467-020-19538-7
  • Zimmet A, Van Eeuwen T, Boczkowska M, Rebowski G, Murakami K, Dominguez R (2020) Cryo-EM Structure of NPF-Bound Human Arp2/3 Complex and Activation Mechanism. Science Advances, 6(23):eaaz7651. DOI: 10.1126/sciadv.aaz7651
  • Rebowski G, Boczkowska M, Drazic A, Ree R, Goris M, Arnesen T, Dominguez R (2020) Mechanism of actin N-terminal acetylation. Science Advances 6(15):eaay8793. DOI: 10.1126/sciadv.aay8793
  • Kumari R, Jiu Y, Carman PJ, Tojkander S, Kogan K, Varjosalo M, Gunning PW, Dominguez R, Lappalainen P (2020) Tropomodulins control the balance between protrusive and contractile structures by stabilizing actin-tropomyosin filaments. Curr Biol 30:767-778. DOI: 10.1016/j.cub.2019.12.049

    2019

  • Dominguez R (2019) Actin: Post-translational modification of actin linked to formin inhibition. Curr Biol 29:R367-R370. DOI: 10.1016/j.cub.2019.03.061
  • Kast DJ and Dominguez R (2019) IRSp53 coordinates AMPK and 14-3-3 signaling to regulate filopodia dynamics and directed cell migration. MBoC 30:1285-1297. DOI: 10.1091/mbc.E18-09-0600
  • Dominguez R (2019) Nucleotide-dependent conformational changes in the actin filament: Subtler than expected. PNAS 116:3959-3961. DOI: 10.1073/pnas.1900799116 (Reprints)
  • Kast DJ and Dominguez R (2019) Mechanism of IRSp53 inhibition by 14-3-3. Nat Commun 10:483. DOI: 10.1038/s41467-019-08317-8 (Reprints)
  • Alqassim SS, Lee IG, Dominguez R (2019) Rickettsia Sca2 Recruits Two Actin Subunits for Nucleation but Lacks WH2 Domains. Biophys J 116:540-550. DOI: 10.1016/j.bpj.2018.12.009
  • Olenick MA, Dominguez R, Holzbaur ELF (2019) Dynein activator HOOK1 is required for trafficking of BDNF-signaling endosomes in neurons. J Cell Biol 218:220-233. DOI: 10.1083/jcb.201805016

2018

  • Carman PJ and Dominguez R (2018) BAR domain proteins – a linkage between cellular membranes, signaling pathways and the actin cytoskeleton. Biophys Rev 10:1587–1604. DOI: 10.1007/s12551-018-0467-7
  • Arnesen T, Marmorstein R, Dominguez R (2018) Actin’s N-terminal acetyltransferase uncovered. Cytoskeleton 75:318-322. DOI: 10.1002/cm.21455
  • Drazic A, Aksnes H, Marie M, Boczkowska M, Varland S, Timmerman E, Foyn H, Glomnes N, Rebowski G, Impens F, Gevaert K, Dominguez R, Arnesen T (2018) NAA80 is actin’s N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility. PNAS 115:4399-4404. DOI: 10.1073/pnas.1718336115
  • Lee IG, Olenick MA, Boczkowska M, Franzini-Armstrong C, Holzbaur EL, Dominguez R (2018) A Conserved Interaction of the Dynein Light Intermediate Chain with Dynein-Dynactin Effectors Necessary for Processivity. Nat Commun 9:986. DOI: 10.1038/s41467-018-03412-8
  • Mentes A, Huehn A, Liu X, Zwolak A, Dominguez R, Shuman H, Ostap EM, Sindelar CV (2018) High-resolution cryo-EM structures of actin-bound myosin states reveal the mechanism of myosin force sensing. PNAS 115:1292-1297. DOI: 10.1073/pnas.1718316115
  • Turegun B, Baker RW, Leschziner AE, Dominguez R (2018) Actin-related proteins regulate the RSC chromatin remodeler by modulating intramolecular interactions of the Sth1 ATPase. Commun Biol 1:1. DOI:10.1038/s42003-017-0002-6 (Reprints)

2017

  • Boczkowska M, Yurtsever Z, Rebowski G, Eck MJ, Dominguez R (2017) Crystal structure of leiomodin 2 in complex with actin: A structural and functional reexamination. Biophys J 113:889-899. DOI: 10.1016/j.bpj.2017.07.007 (New & Notable by Thomas Pollard in Biophys J 113:762-764)
  • Fowler VM & Dominguez R (2017) Tropomodulins and Leiomodins: actin pointed end caps and nucleators in muscles. Biophys J 112:1742-1760. DOI: 10.1016/j.bpj.2017.03.034
  • Kast DJ & Dominguez R (2017) The cytoskeleton-autophagy connection. Curr Biol 27:R318-R326. DOI: 10.1016/j.cub.2017.02.061
  • Burke TA, Harker AJ, Dominguez R, Kovar DR (2017) The bacterial virulence factors VopL and VopF nucleate actin from the pointed end. J Cell Biol 216. DOI:10.1083/jcb.201608104

2016

  • Olenick MA, Tokito M, Boczkowska M, Dominguez R, Holzbaur EL (2016) HOOK adaptors induce unidirectional processive motility by enhancing the dynein-dynactin interaction. J Biol Chem. 291:18239-18251. DOI: 10.1074/jbc.M116.738211
  • Dominguez R (2016) The WH2 domain and actin nucleation: Necessary but insufficient. Trends Biochem Sci 41:478-490. DOI: 10.1016/j.tibs.2016.03.004

2015

  • Boczkowska M, Rebowski G, Dominguez R (2015) The chalenges of polydisperse SAXS data analysis: Two SAXS studies of PICK1 produce different structural models. Stucture 23:1967-1968. DOI:10.1016/j.str.2015.10.007
  • Boczkowska M, Rebowski G, Kremneva E, Lappalainen P, Dominguez R (2015) How Leiomodin and Tropomodulin use a common fold for different actin assembly functions. Nature Commun 6:8314. DOI:10.1038/ncomms9314
  • Kast DJ & Dominguez R (2015) WHAMM links actin assembly via the Arp2/3 complex to autophagy. Autophagy 11:1702-1704. DOI: 10.1080/15548627.2015.1073434
  • Kast DJ, Zajac AL, Holzbaur EL, Ostap EM, Dominguez R (2015) WHAMM directs the Arp2/3 complex to the ER for autophagosome biogenesis through and actin comet tail mechanism. Curr Biol 25:1791-1797. DOI: 10.1016/j.cub.2015.05.042
  • Dominguez R (2015) Subversive bacteria reveal new tricks in their cytoskeleton-hijacking arsenal. Nature Struct Mol Biol 22:178-179. DOI: 10.1038/nsmb.2976
  • Madasu Y, Yang C, Boczkowska M, Bethoney KA, Zwolak A, Rebowski G, Svitkina T, and Dominguez R (2015) PICK1 is implicated in organelle motility in an Arp2/3 complex-independent manner. Mol Biol Cell 26:1308-1322. DOI: 10.1091/mbc.E14-10-1448

2014

  • Edwards M, Zwolak A, Schafer DA, Sept D, Dominguez R, Cooper JA (2014) Capping protein regulators fine-tune actin assembly dynamics. Nat Rev Mol Cell Biol 15:677-689. DOI: 10.1038/nrm3869
  • Kremneva E, Makkonen MH, Skwarek-Maruszewska A, Gateva G, Michelot A, Dominguez R, Lappalainen P (2014) Cofilin-2 controls actin filament length in muscle sarcomeres. Dev Cell 31:215-226. DOI: 10.1016/j.devcel.2014.09.002
  • Rao JN, Madasu Y, Dominguez R (2014) Mechanism of actin filament pointed-end capping by tropomodulin. Science 345:463-467. DOI: 10.1126/science.1256159 (Reprints)
  • Kast DJ, Yang C, Disanza A, Boczkowska M, Madasu Y, Scita G, Svitkina T and Dominguez R (2014) Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors. Nature Struct Mol Biol 21:413-422. DOI: 10.1038/nsmb.2781
  • Boczkowska M, Rebowski G, Kast DJ, Dominguez R (2014) Structural analysis of the transitional state of Arp2/3 complex activation by two actin-bound WCAs. Nature Commun 5:3308. DOI:10.1038/ncomms4308
  • Shuman H, Greenberg MJ, Zwolak A, Lin T, Sindelar CV, Dominguez R, Ostap EM (2014) A vertebrate myosin-I structure reveals unique insights into myosin mechanochemical tuning. PNAS 111:2116-2121. DOI: 10.1073/pnas.1321022111

2013

  • Turegun B, Kast D, Dominguez R (2013) Subunit Rtt102 controls the conformation of the Arp7/9 heterodimer and its interactions with nucleotide and the catalytic subunit of SWI/SNF remodelers. J Biol Chem 288:35758-35768. DOI: 10.1074/jbc.M113.514083
  • Zwolak A, Yang C, Feeser EA, Ostap EM, Svitkina T, Dominguez R (2013) CARMIL leading edge localization depends on a non-canonical PH domain and dimerization. Nature Commun 4:2523. DOI:10.1038/ncomms3523
  • Disanza A, Bisi S, Winterhoff M, Milanesi F, Ushakov DS, Kast D, Marighetti P, Romet-Lemonne G, Müller HM, Nickel W, Linkner J, Waterschoot D, Ampè C, Cortellino S, Palamidessi A, Dominguez R, Carlier MF, Faix J, Scita G (2013) Cdc42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP. EMBO J 32:2735-2750. DOI: 10.1038/emboj.2013.208
  • Boczkowska M, Rebowski G, Dominguez R (2013) GMF interacts with Arp2/3 complex in a nucleotide state-dependent manner. J Biol Chem 288:25683-25688. DOI: 10.1074/jbc.C113.493338
  • Madasu Y, Suarez C, Kast DJ, Kovar DR and Dominguez R (2013) Rickettsia Sca2 has evolved formin-like activity through a different molecular mechanism. PNAS 110:E2677-E2686. DOI: 10.1073/pnas.1307235110

2012

  • Kallenbach NR & Dominguez R (2012) Dystrophin's tandem calponin-homology domains: Is the case closed? Biophys J 103:1818-181. DOI: 10.1016/j.bpj.2012.09.037
  • Jensen MH, Morris EJ, Huang R, Rebowski G, Dominguez R, Weitz DA, Moore JR, Wang CL (2012) The conformational state of actin filaments regulates branching by actin-related protein 2/3 (Arp2/3) complex. J Biol Chem 287:31447-31453. DOI: 10.1074/jbc.M112.350421
  • Rao JN, Rivera-Santiago R, Li W, Lehman R, Dominguez R (2012) Structural analysis of Smooth muscle tropomyosin alpha and beta isoforms. J Biol Chem 287:3167-3174. DOI: 10.1074/jbc.M111.307330
  • Dominguez R & Namgoong S (2012) Chapter 4.4: Actin Filament Nucleation and Elongation. Egelman E (Ed) In Comprehensive Biophysics Elsevier. ISBN: 9780123749208, eBook ISBN: 9780080957180

2011

  • Namgoong S, Boczkowska M, Glista MJ, Winkelman JD, Rebowski G, Kovar DR, Dominguez R (2011) Mechanism of actin filament nucleation by Vibrio VopL and implications for tandem-W domain nucleation. Nature Struct Mol Biol 18:1060-1067. DOI: 10.1038/nsmb.2109
  • Jansen S, Collins A, Yang C, Rebowski G, Svitkina T*, Dominguez R* (2011) Mechanism of Actin Filament Bundling by Fascin. J Biol Chem 268:30087-30096. DOI: 10.1074/jbc.M111.251439
  • Pykalainen A, Boczkowska M, Zhao H, Saarikangas J, Rebowski G, Jansen M, Hakanen J, Koskela E, Peranen J, Vihinen H, Jokitalo E, Salminen M, Ikonen E, Dominguez R*, Lappalainen P* (2011) Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures. Nature Struct Mol Biol 18:902-907. DOI: 10.1038/nsmb.2079
  • Kast D & Dominguez R (2011) Arp you ready for actin in the nucleus? EMBO J 30:2097-2098. DOI: 10.1038/emboj.2011.150
  • Dominguez R (2011) Tropomyosin: the gatekeeper's view of the actin filament revealed. Biophys J 100:797-798. DOI: 10.1016/j.bpj.2011.01.018
  • Dominguez R & Holmes KC (2011) Actin Structure And Function. Annu Rev Biophys 40:169-186. DOI: 10.1146/annurev-biophys-042910-155359
  • Gorelik R, Yang C, Kameswaran V, Dominguez R, Svitkina T (2011) Mechanisms of plasma membrane targeting of formin mDia2 through its amino terminal domains. Mol Biol Cell 22:189-201. DOI: 10.1091/mbc.E10-03-0256

2010

  • Rebowski G, Namgoong S, Boczkowska M, Leavis P, Navaza J, Dominguez R (2010) Structure of a Longitudinal Actin Dimer Assembled by Tandem W Domains - Implications for Actin Filament Nucleation. J Mol Biol 403:11-23. DOI: 10.1016/j.jmb.2010.08.040
  • Skwarek-Maruszewska A, Boczkowska M, Zajac A, Kremneva E, Svitkina T, Dominguez R*, Lappalainen P* (2010) Different Localizations and Cellular Behaviors of Leiomodin and Tropomodulin in Mature Cardiomyocyte Sarcomeres. Mol Biol Cell 21:3352-3361. DOI: 10.1091/mbc.E10-02-0109
  • Lee SH & Dominguez R (2010) Regulation of actin cytoskeleton dynamics in cells. Mol Cells 29:311-325. DOI: 10.1007/s10059-010-0053-8
  • Baek K, Knodler A, Lee SH, Zhang X, Orlando K, Zhang J, Foskett TJ, Guo W, Dominguez R (2010) Structure-Function Study of the N-terminal Domain of Exocyst Subunit Sec3  J Biol Chem 285:10424-10433. DOI: 10.1074/jbc.M109.096966
  • Dominguez R (2010) Structural insights into de novo actin polymerization. Curr Opin Struct Biol 20:217-225. DOI: 10.1016/j.sbi.2009.12.012
  • Kim HR, Graceffa P, Ferron, F, Gallant C, Boczkowska M, Dominguez R, Morgan KG (2010) Actin Polymerization in Differentiated Vascular Smooth Muscle Cells Requires Vasodilator-Stimulated Phosphoprotein (VASP).  Am J Physiol Cell Physiol 298:C559-C571. DOI: 10.1152/ajpcell.00431.2009

2009

  • Dominguez R (2009) Actin filament nucleation and elongation factors — Structure-function relationships. Crit Rev Biochem Mol Biol 44:351-366. DOI: 10.3109/10409230903277340

  • Shvetsov A, Berkane E, Chereau D, Dominguez R, Reisler E (2009) The actin-binding domain of cortactin is dynamic and unstructed and affects lateral and longitudinal contacts in F-actin. Cell Motil Cytoskeleton 66:90-98. DOI: 10.1002/cm.20328

2008

  • Lee SH, Baek K & Dominguez R (2008) Large nucleotide-dependent conformational change in Rab28. FEBS Letters 582:4107-4111. DOI: 10.1016/j.febslet.2008.11.008
  • Baek K, Liu X, Ferron F, Shu S, Korn ED, Dominguez R (2008) Modulation of actin structure and function by phosphorylation of Tyr-53 and profilin binding. PNAS 105:11748–11753. DOI: 10.1073/pnas.0805852105
  • Rebowski G, Boczkowska M, Hayes DB, Guo L, Irving TC, Dominguez R (2008) X-ray scattering study of actin polymerization nuclei assembled by tandem W domains. PNAS 105:10785-10790. DOI: 10.1073/pnas.0801650105
  • Boczkowska M, Rebowski G, Petoukhov MV, Hayes DB, Svergun DI, Dominguez R (2008) X-ray Scattering Study of Activated Arp2/3 Complex with Bound Actin-WCA. Structure 16:695-704. DOI: 10.1016/j.str.2008.02.013
  • Chereau D, Boczkowska M, Skwarek-Maruszewska A, Fujiwara I, Hayes DB, Rebowski G, Lappalainen P, Pollard TD, Dominguez R (2008) Leiomodin Is an Actin Filament Nucleator in Muscle Cells. Science 320:239-243. DOI: 10.1126/science.1155313
  • Lee SH, Weins A, Hayes DB, Pollak, MR, Dominguez R (2008) Crystal structure of the actin-binding domain of α-actinin-4 Lys255Glu mutant implicated in focal segmental glomerulosclerosis. J Mol Biol 376:317-324. DOI: 10.1016/j.jmb.2007.11.084

2007

  • Ferron F, Rebowski G, Lee SH, Dominguez R (2007) Structural basis for the recruitment of profilin–actin complexes during filament elongation by Ena/VASP. EMBO J 26:4597-4606. DOI: 10.1038/sj.emboj.7601874
  • Lee SH, Hayes DB, Rebowski G, Tardieux I, Dominguez R (2007) Toxofilin from Toxoplasma gondii forms a ternary complex with an antiparallel actin dimer. PNAS 104:16122-16127. DOI: 10.1073/pnas.0705794104
  • Dominguez R (2007) The β-Thymosin/WH2 Fold: Multifunctionality and Structure. Ann N Y Acad Sci 1112:86-94. DOI: 10.1196/annals.1415.011
  • Lee SH, Kerff F, Chereau D, Ferron F, Klug A, Dominguez R (2007) Structural basis for the actin-binding function of Missing-in-Metastasis. Structure 15:145-155. DOI: 10.1016/j.str.2006.12.005

2006

  • Pant K, Chereau D, Hatch V, Dominguez R, Lehman W (2006) Cortactin binding to F-actin revealed by electron microscopy and 3D reconstruction. J Mol Biol 359:840-847. DOI: 10.1016/j.jmb.2006.03.065
  • Dominguez R (2006) A common binding site for actin-binding proteins on the actin surface. Lappalainen P (Ed). In Actin Monomer-Binding Proteins. Landes Bioscience
  • Borrego-Diaz E, Kerff F, Lee SH, Ferron F, Li Y, Dominguez R (2006) Crystal structure of the actin-binding domain of α-actinin 1: evaluating two competing actin-binding models. J Struct Biol 155:230-238. DOI: 10.1016/j.jsb.2006.01.013
  • Chereau D, Dominguez R (2006) Understanding the role of the G-actin-binding domain of Ena/VASP in actin assembly. J Struct Biol 155:195-201. DOI: 10.1016/j.jsb.2006.01.012

2005

  • Chereau D, Kerff F, Graceffa P, Grabarek Z, Langsetmo K, Dominguez R (2005) Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly. PNAS 102:16644-16649. DOI: 10.1073/pnas.0507021102
  • Terrak M, Rebowski G, Lu RC, Grabarek Z, Dominguez R (2005) Structure of the light chain-binding domain of myosin V. PNAS 102:12718-12723. DOI: 10.1073/pnas.0503899102

2004

  • Dominguez R. (2004) Actin-binding proteins - a unifying hypothesis. Trends Biochem Sci 29:572-578. DOI: 10.1016/j.tibs.2004.09.004
  • Terrak M, Kerff F, Langsetmo K., Tao T, Dominguez R (2004) Structural basis of protein phosphatase 1 regulation. Nature 429:780-784. DOI: 10.1038/nature02582

2003

  • Dominguez R, Graceffa P (2003) Solution properties of TMR-actin: when biochemical and crystal data agree.
    Biophys J 85:2073-2074. DOI: 10.1016/S0006-3495(03)74635-9
  • Graceffa P & Dominguez R (2003) Crystal structure of monomeric actin in the ATP state. Structural basis of nucleotide-dependent actin dynamics. J Biol Chem 278:34172-34180. DOI: 10.1074/jbc.M303689200
  • Terrak M, Wu G, Stafford WF, Lu RC, Dominguez R (2003) Two distinct myosin light chain structures are induced by specific variations within the bound IQ motifs - Functional implications. EMBO J 22:362-371. DOI: 10.1093/emboj/cdg058

2002

  • Terrak M, Otterebin LR, Wu G, Palecanda LA, Lu RC, Dominguez R (2002) Crystallization, X-ray characterization and selenomethionine phasing of Mlc1p bound to IQ motifs from myosin V. Acta Cryst D58:1882-1885. DOI: 10.1107/s0907444902013951
  • Otterbein LR, Cosio C, Graceffa P, Dominguez R (2002) Crystal structures of the vitamin D-binding protein and its complex with actin: Structural basis of the actin-scavenger system. PNAS 9:8003-8008. DOI: 10.1073/pnas.122126299
  • Otterbein LR, Kordowska J, Witte-Hoffmann C, Wang CL, Dominguez R (2002) Crystal Structures of S100A6 in the Ca2+-Free and Ca2+-Bound States. The Calcium Sensor Mechanism of S100 Proteins Revealed at Atomic Resolution. Structure 10:557-567. DOI: 10.1016/s0969-2126(02)00740-2

2001

  • Otterbein LR, Graceffa P, Dominguez R (2001) The crystal structure of uncomplexed actin in the ADP state. Science 293:708-711. DOI: 10.1126/science.1059700
  • Madrazo J, Brown JH, Litvinovich S, Dominguez R, Yakovlev S, Medved L, Cohen C (2001) Crystal structure of the central region of bovine fibrinogen (E5 fragment) at 1.4-A resolution. PNAS 98:11967-11972. DOI: 10.1073/pnas.211439798
  • Brown JH, Kim KH, Jun G, Greenfield NJ, Dominguez R, Volkmann N, Hitchcock-DeGregori SE, Cohen C (2001) Deciphering the design of the tropomyosin molecule. PNAS 98:8496-8501. DOI: 10.1073/pnas.131219198