• Arnesen T, Marmorstein R, Dominguez R (2018) Actin’s N-terminal Acetyltransferase Uncovered. Cytoskeleton DOI: 10.1002/cm.21455
  • Drazic A, Aksnes H, Marie M, Boczkowska M, Varland S, Timmerman E, Foyn H, Glomnes N, Rebowski G, Impens F, Gevaert K, Dominguez R, Arnesen T (2018) NAA80 is actin’s N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility. PNAS 115:4399-4404. doi: 10.1073/pnas.1718336115
  • Lee IG, Olenick MA, Boczkowska M, Franzini-Armstrong C, Holzbaur EL, Dominguez R (2018) A Conserved Interaction of the Dynein Light Intermediate Chain with Dynein-Dynactin Effectors Necessary for Processivity. Nat Commun 9:986. doi: 10.1038/s41467-018-03412-8
  • Mentes A, Huehn A, Liu X, Zwolak A, Dominguez R, Shuman H, Ostap EM, Sindelar CV (2018) High-resolution cryo-EM structures of actin-bound myosin states reveal the mechanism of myosin force sensing. PNAS 115:1292-1297. doi: 10.1073/pnas.1718316115
  • Turegun B, Baker RW, Leschziner AE, Dominguez R (2018) Actin-related proteins regulate the RSC chromatin remodeler by modulating intramolecular interactions of the Sth1 ATPase Commun Biol 1:1 doi:10.1038/s42003-017-0002-6


  • Boczkowska M, Yurtsever Z, Rebowski G, Eck MJ, Dominguez R (2017) Crystal structure of leiomodin 2 in complex with actin: A structural and functional reexamination Biophys J 113:889-899 (New & Notable by Thomas Pollard in Biophys J 113:762-764)
  • Fowler VM & Dominguez R (2017) Tropomodulins and Leiomodins: actin pointed end caps and nucleators in muscles. Biophys J 112:1742-1760
  • Kast DJ & Dominguez R (2017) The cytoskeleton-autophagy connection. Curr Biol 27:R318-R326
  • Burke TA, Harker AJ, Dominguez R, Kovar DR (2017) The bacterial virulence factors VopL and VopF nucleate actin from the pointed end. J Cell Biol 216 doi:10.1083/jcb.201608104


  • Olenick MA, Tokito M, Boczkowska M, Dominguez R, Holzbaur EL (2016) Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction. J Biol Chem. 291:18239-18251.
  • Dominguez R (2016) The WH2 Domain and Actin Nucleation: Necessary but Insufficient. Trends Biochem Sci 41:478-490


  • Boczkowska M, Rebowski G, Dominguez R (2015) The chalenges of polydisperse SAXS data analysis: Two SAXS studies of PICK1 produce different structural models. Stucture 23:1967-1968. DOI:10.1016/j.str.2015.10.007
  • Boczkowska M, Rebowski G, Kremneva E, Lappalainen P, Dominguez R (2015) How Leiomodin and Tropomodulin use a common fold for different actin assembly functions. Nature Commun 6:8314. DOI:10.1038/ncomms9314
  • Kast DJ & Dominguez R (2015) WHAMM links actin assembly via the Arp2/3 complex to autophagy. Autophagy 11:1702-1704
  • Kast DJ, Zajac AL, Holzbaur EL, Ostap EM, Dominguez R (2015) WHAMM directs the Arp2/3 complex to the ER for autophagosome biogenesis through and actin comet tail mechanism. Curr Biol 25:1791-1797
  • Dominguez R (2015) Subversive bacteria reveal new tricks in their cytoskeleton-hijacking arsenal. Nature Struct Mol Biol 22:178-179
  • Madasu Y, Yang C, Boczkowska M, Bethoney KA, Zwolak A, Rebowski G, Svitkina T, and Dominguez R (2015) PICK1 is implicated in organelle motility in an Arp2/3 complex-independent manner. Mol Biol Cell 26:1308-1322


  • Edwards M, Zwolak A, Schafer DA, Sept D, Dominguez R, Cooper JA (2014) Capping protein regulators fine-tune actin assembly dynamics. Nat Rev Mol Cell Biol 15:677-689
  • Kremneva E, Makkonen MH, Skwarek-Maruszewska A, Gateva G, Michelot A, Dominguez R, Lappalainen P (2014) Cofilin-2 controls actin filament length in muscle sarcomeres. Dev Cell 31:215-226
  • Rao JN, Madasu Y, Dominguez R (2014) Mechanism of actin filament pointed-end capping by tropomodulin. Science 345:463-467 (Links to: FullText & Reprints)
  • Kast DJ, Yang C, Disanza A, Boczkowska M, Madasu Y, Scita G, Svitkina T and Dominguez R (2014) Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors. Nature Struct Mol Biol 21:413-422.
  • Boczkowska M, Rebowski G, Kast DJ, Dominguez R (2014) Structural analysis of the transitional state of Arp2/3 complex activation by two actin-bound WCAs. Nature Commun 5:3308. DOI:10.1038/ncomms4308
  • Shuman H, Greenberg MJ, Zwolak A, Lin T, Sindelar CV, Dominguez R, Ostap EM (2014) A vertebrate myosin-I structure reveals unique insights into myosin mechanochemical tuning. PNAS 111:2116-2121


  • Turegun B, Kast D, Dominguez R (2013) Subunit Rtt102 controls the conformation of the Arp7/9 heterodimer and its interactions with nucleotide and the catalytic subunit of SWI/SNF remodelers. J Biol Chem 288:35758-35768
  • Zwolak A, Yang C, Feeser EA, Ostap EM, Svitkina T, Dominguez R (2013) CARMIL leading edge localization depends on a non-canonical PH domain and dimerization. Nature Commun 4:2523. DOI:10.1038/ncomms3523
  • Disanza A, Bisi S, Winterhoff M, Milanesi F, Ushakov DS, Kast D, Marighetti P, Romet-Lemonne G, Müller HM, Nickel W, Linkner J, Waterschoot D, Ampè C, Cortellino S, Palamidessi A, Dominguez R, Carlier MF, Faix J, Scita G (2013) Cdc42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP. EMBO J 32:2735-2750
  • Boczkowska M, Rebowski G, Dominguez R (2013) GMF interacts with Arp2/3 complex in a nucleotide state-dependent manner. J Biol Chem 288:25683-25688
  • Madasu Y, Suarez C, Kast DJ, Kovar DR and Dominguez R (2013) Rickettsia Sca2 has evolved formin-like activity through a different molecular mechanism. PNAS 110:E2677-E2686


  • Kallenbach NR & Dominguez R (2012) Dystrophin's tandem calponin-homology domains: Is the case closed? Biophys J 103:1818-181
  • Jensen MH, Morris EJ, Huang R, Rebowski G, Dominguez R, Weitz DA, Moore JR, Wang CL (2012) The conformational state of actin filaments regulates branching by actin-related protein 2/3 (Arp2/3) complex. J Biol Chem 287:31447-31453
  • Rao JN, Rivera-Santiago R, Li W, Lehman R, Dominguez R (2012) Structural analysis of Smooth muscle tropomyosin alpha and beta isoforms. J Biol Chem 287:3167-3174
  • Dominguez R & Namgoong S (2012) Chapter 4.4: Actin Filament Nucleation and Elongation. Egelman E (Ed) In Comprehensive Biophysics Elsevier


  • Namgoong S, Boczkowska M, Glista MJ, Winkelman JD, Rebowski G, Kovar DR, Dominguez R (2011) Mechanism of actin filament nucleation by Vibrio VopL and implications for tandem-W domain nucleation. Nature Struct Mol Biol 18:1060-1067
  • Jansen S, Collins A, Yang C, Rebowski G, Svitkina T*, Dominguez R* (2011) Mechanism of Actin Filament Bundling by Fascin. J Biol Chem 268:30087-30096
  • Pykalainen A, Boczkowska M, Zhao H, Saarikangas J, Rebowski G, Jansen M, Hakanen J, Koskela E, Peranen J, Vihinen H, Jokitalo E, Salminen M, Ikonen E, Dominguez R*, Lappalainen P* (2011) Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures. Nature Struct Mol Biol 18:902-907
  • Kast D & Dominguez R (2011) Arp you ready for actin in the nucleus? EMBO J 30:2097-2098
  • Dominguez R (2011) Tropomyosin: the gatekeeper's view of the actin filament revealed. Biophys J 100:797-798
  • Dominguez R & Holmes KC (2011) Actin Structure And Function. Annu Rev Biophys 40:169-186
  • Gorelik R, Yang C, Kameswaran V, Dominguez R, Svitkina T (2011) Mechanisms of plasma membrane targeting of formin mDia2 through its amino terminal domains. Mol Biol Cell 22:189-201


  • Rebowski G, Namgoong S, Boczkowska M, Leavis P, Navaza J, Dominguez R (2010) Structure of a Longitudinal Actin Dimer Assembled by Tandem W Domains - Implications for Actin Filament Nucleation. J Mol Biol 403:11-23
  • Skwarek-Maruszewska A, Boczkowska M, Zajac A, Kremneva E, Svitkina T, Dominguez R*, Lappalainen P* (2010) Different Localizations and Cellular Behaviors of Leiomodin and Tropomodulin in Mature Cardiomyocyte Sarcomeres. Mol Biol Cell 21:3352-3361
  • Lee SH & Dominguez R (2010) Regulation of actin cytoskeleton dynamics in cells. Mol Cells 29:311-325
  • Baek K, Knodler A, Lee SH, Zhang X, Orlando K, Zhang J, Foskett TJ, Guo W, Dominguez R (2010) Structure-Function Study of the N-terminal Domain of Exocyst Subunit Sec3  J Biol Chem 285:10424-10433
  • Dominguez R (2010) Structural insights into de novo actin polymerization. Curr Opin Struct Biol 20:217-225
  • Kim HR, Graceffa P, Ferron, F, Gallant C, Boczkowska M, Dominguez R, Morgan KG (2010) Actin Polymerization in Differentiated Vascular Smooth Muscle Cells Requires Vasodilator-Stimulated Phosphoprotein (VASP).  Am J Physiol Cell Physiol 298:C559-C571


  • Dominguez R (2009) Actin filament nucleation and elongation factors — Structure-function relationships. Crit Rev Biochem Mol Biol 44:351-366

  • Shvetsov A, Berkane E, Chereau D, Dominguez R, Reisler E (2009) The actin-binding domain of cortactin is dynamic and unstructed and affects lateral and longitudinal contacts in F-actin. Cell Motil Cytoskeleton 66:90-98


  • Lee SH, Baek K & Dominguez R (2008) Large nucleotide-dependent conformational change in Rab28. FEBS Letters 582:4107-4111
  • Baek K, Liu X, Ferron F, Shu S, Korn ED, Dominguez R (2008) Modulation of actin structure and function by phosphorylation of Tyr-53 and profilin binding. PNAS 105:11748–11753
  • Rebowski G, Boczkowska M, Hayes DB, Guo L, Irving TC, Dominguez R (2008) X-ray scattering study of actin polymerization nuclei assembled by tandem W domains. PNAS 105:10785-10790
  • Boczkowska M, Rebowski G, Petoukhov MV, Hayes DB, Svergun DI, Dominguez R (2008) X-ray Scattering Study of Activated Arp2/3 Complex with Bound Actin-WCA. Structure 16:695-704
  • Chereau D, Boczkowska M, Skwarek-Maruszewska A, Fujiwara I, Hayes DB, Rebowski G, Lappalainen P, Pollard TD, Dominguez R (2008) Leiomodin Is an Actin Filament Nucleator in Muscle Cells. Science 320:239-243
  • Lee SH, Weins A, Hayes DB, Pollak, MR, Dominguez R (2008) Crystal structure of the actin-binding domain of α-actinin-4 Lys255Glu mutant implicated in focal segmental glomerulosclerosis. J Mol Biol 376:317-324


  • Ferron F, Rebowski G, Lee SH, Dominguez R (2007) Structural basis for the recruitment of profilin–actin complexes during filament elongation by Ena/VASP. EMBO J 26:4597-4606
  • Lee SH, Hayes DB, Rebowski G, Tardieux I, Dominguez R (2007) Toxofilin from Toxoplasma gondii forms a ternary complex with an antiparallel actin dimer. PNAS 104:16122-16127
  • Dominguez R (2007) The β-Thymosin/WH2 Fold: Multifunctionality and Structure. Ann N Y Acad Sci 1112:86-94
  • Lee SH, Kerff F, Chereau D, Ferron F, Klug A, Dominguez R (2007) Structural basis for the actin-binding function of Missing-in-Metastasis. Structure 15:145-155


  • Pant K, Chereau D, Hatch V, Dominguez R, Lehman W (2006) Cortactin binding to F-actin revealed by electron microscopy and 3D reconstruction. J Mol Biol 359:840-847
  • Dominguez R (2006) A common binding site for actin-binding proteins on the actin surface. Lappalainen P (Ed). In Actin Monomer-Binding Proteins. Landes Bioscience
  • Borrego-Diaz E, Kerff F, Lee SH, Ferron F, Li Y, Dominguez R (2006) Crystal structure of the actin-binding domain of α-actinin 1: evaluating two competing actin-binding models. J Struct Biol 155:230-238
  • Chereau D, Dominguez R (2006) Understanding the role of the G-actin-binding domain of Ena/VASP in actin assembly. J Struct Biol 155:195-201


  • Chereau D, Kerff F, Graceffa P, Grabarek Z, Langsetmo K, Dominguez R (2005) Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly. PNAS 102:16644-16649
  • Terrak M, Rebowski G, Lu RC, Grabarek Z, Dominguez R (2005) Structure of the light chain-binding domain of myosin V. PNAS 102:12718-12723


  • Dominguez R. (2004) Actin-binding proteins - a unifying hypothesis. Trends Biochem Sci 29:572-578
  • Terrak M, Kerff F, Langsetmo K., Tao T, Dominguez R (2004) Structural basis of protein phosphatase 1 regulation. Nature 429:780-784


  • Dominguez R, Graceffa P (2003) Solution properties of TMR-actin: when biochemical and crystal data agree.
    Biophys J 85:2073-2074
  • Graceffa P & Dominguez R (2003) Crystal structure of monomeric actin in the ATP state. Structural basis of nucleotide-dependent actin dynamics. J Biol Chem 278:34172-34180
  • Terrak M, Wu G, Stafford WF, Lu RC, Dominguez R (2003) Two distinct myosin light chain structures are induced by specific variations within the bound IQ motifs - Functional implications. EMBO J 22:362-371


  • Terrak M, Otterebin LR, Wu G, Palecanda LA, Lu RC, Dominguez R (2002) Crystallization, X-ray characterization and selenomethionine phasing of Mlc1p bound to IQ motifs from myosin V. Acta Cryst D58:1882-1885
  • Otterbein LR, Cosio C, Graceffa P, Dominguez R (2002) Crystal structures of the vitamin D-binding protein and its complex with actin: Structural basis of the actin-scavenger system. PNAS 9:8003-8008
  • Otterbein LR, Kordowska J, Witte-Hoffmann C, Wang CL, Dominguez R (2002) Crystal Structures of S100A6 in the Ca2+-Free and Ca2+-Bound States. The Calcium Sensor Mechanism of S100 Proteins Revealed at Atomic Resolution. Structure 10:557-567


  • Otterbein LR, Graceffa P, Dominguez R (2001) The crystal structure of uncomplexed actin in the ADP state. Science 293:708-711
  • Madrazo J, Brown JH, Litvinovich S, Dominguez R, Yakovlev S, Medved L, Cohen C (2001) Crystal structure of the central region of bovine fibrinogen (E5 fragment) at 1.4-A resolution. PNAS 98:11967-11972
  • Brown JH, Kim KH, Jun G, Greenfield NJ, Dominguez R, Volkmann N, Hitchcock-DeGregori SE, Cohen C (2001) Deciphering the design of the tropomyosin molecule. PNAS 98:8496-8501