PET Analysis Laboratory (PETAL) Selected Publications

Key Publications

  • Young, AJ, AR Pantel, V Viswanath, TL Dominguez, M Makvandi, H Lee, S Li, EK Schubert, DA Pryma, MD Farwell, RH Mach, F Simpkins, LL Lin, DA Mankoff, and RK Doot: "Kinetic and static analysis of poly-(adenosine diphosphate-ribose) polymerase-1 (PARP-1) targeted 18F-FluorThanatrace (18F-FTT) PET images of ovarian cancer." J Nucl Med. 63: 44-50, 2022.
  • Duong, MT, YJ Chen, RK Doot, AJ Young, H Lee, J Cai, A Pilania, DA Wolk, and IM Nasrallah: "Astrocyte activation imaging with 11C-acetate and amyloid PET in mild cognitive impairment due to Alzheimer pathology." Nucl Med Commun. 42(11): 1261-1269, 2021.
  • Doot, RK, AJ Young, ME Daube-Witherspoon, D Alexoff, KJ Labban, H Lee, Z Wu, Z Zha, SR Choi, KH Ploessl, EK Schubert, H Lee, L Zhu, JS Reddin, JS Karp, H Kung, and DA Pryma: "Biodistribution, dosimetry, and temporal signal-to-noise ratio analyses of normal and cancer uptake of [68Ga]Ga-P15-041, a gallium-68 labeled bisphosphonate, from first-in-human studies." Nucl Med Biol. 86-87: 1-8, 2020.
  • Doot, RK, JG Dubroff, KJ Labban, and RH Mach: "Selectivity of probes for PET imaging of dopamine D3 receptors." Neurosci Lett. 691: 18-25, 2019.
  • Doot, RK, JG Dubroff, JS Scheuermann, KJ Labban, J Cai, CJ Hsieh, S Li, H Lee, EK Schubert, C Hou, R Sheffer, A Schmitz, K Xu, and RH Mach: "Validation of gallbladder absorbed radiation dose reduction simulation: human dosimetry of [18F]fluortriopride." EJNMMI Phys. 5: 1-12, 2018.
  • Dubroff, JG, RK Doot, M Falcone, RA Schnoll, R Tyndale, C Hou, A Schmitt, and C Lerman: "Decreased nicotinic receptor availability in smokers with slow rates of nicotine metabolism." J Nucl Med. 56: 1724-9, 2015.
  • Doot, RK, BF Kurland, PE Kinahan, and DA Mankoff: "Design considerations for using PET as a response measure in single site and multicenter clinical trials." Acad Radiol. 19(2): 184-90, 2012.
  • Pantel, AR, V Viswanath, M Muzi, RK Doot, and DA Mankoff: "Principles of Tracer Kinetic Analysis in Oncology, Part I: Principles and Overview of Methodology." J Nucl Med. 63(3): 342-352, 2022.
  • Lee HS, SW Schwarz, EK Schubert, DL Chen, RK Doot, M Makvandi, LL Lin, ES McDonald, DA Mankoff, and RH Mach: "The Development of [18F] Fluorthanatrace: A PET Radiotracer for Imaging Poly (ADP-Ribose) Polymerase-1." Radiol Imaging Cancer. 4(21): 1-11, 2022. COVER.
  • McDonald, ES, AR Pantel, PD Shah, MD Farwell, AS Clark, RK Doot, DA Pryma, and SD Carlin: "In vivo visualization of PARP inhibitor pharmacodynamics." JCI Insight. 6(8): 1-4, 2021.
  • Viswanath, V, R Zhou, H  Lee, S Li, A Cragin, RK Doot, DA Mankoff, and AR Pantel: "Kinetic modeling of 18F-(2S,4R)4-fluoroglutamine in mouse models of breast cancer to estimate glutamine pool size as an indicator of tumor glutamine metabolism." J Nucl Med. 62(8): 1154-1162, 2021.
  • McDonald, ES, RK Doot, A Pantel, MD Farwell, RH Mach, KN Maxwell, and DA Mankoff: "Positron Emission Tomography Imaging of Poly-(Adenosine Diphosphate-Ribose) Polymerase 1 Expression in Breast Cancer: A Nonrandomized Clinical Trial. " JAMA Oncol. 6(6): 921-923, 2020.
  • McDonald ES, RK Doot, AJ Young, EK Schubert, DA Pryma, MD Farwell, J Tchou, A Nayak, A Ziober, MD Feldman, A DeMichele, AS Clark, PD Shah, H Lee, SD Carlin, RH Mach, and DA Mankoff: "Breast cancer 18F-ISO-1 uptake as a marker of proliferation status." J Nucl Med. 61(5): 665-670, 2020.
  • Doot, RK: "Practical methods for estimating metabolic flux (Ki) to assess response to therapy via static PET scans." J Nucl Med. 60(3): 320-321, 2019.
  • Reis ES, N Berger, X Wang, S Koutsogiannaki, RK Doot, JT Gumas, PG Foukas, RRG Resuello, JV Tuplano, D Kukis, AF Tarantal, AJ Young, T Kajikawa, AM Soulika, DC Mastellos, D Yancopoulou, AR Biglarnia, M Huber-Lang, G Hajishengallis, B Nilsson, and JD Lambris: "Safety profile after prolonged C3 inhibition." Clin Immunol. 197: 96-106, 2018.
  • Doot, RK: "Getting the most out of 18F-FDG PET scans: The predictive value of 18F-FDG PET-derived blood flow estimates for breast cancer." J Nucl Med. 57(11): 1667-8, 2016.
  • Doot, RK, LA Pierce, D Byrd, B Elston, KC Allberg, and PE Kinahan: "Biases in multicenter longitudinal PET standardized uptake value measurements." Transl Oncol. 7(1): 48-54, 2014.
  • Doot, RK, ES McDonald, and DA Mankoff: "Role of PET quantitation in the monitoring of cancer response to treatment: review of approaches and human clinical trials." Clin Transl Imaging. 2(4): 295-303, 2014.
  • Fahey, FH, PE Kinahan, RK Doot, M Kocak, H Thurston, and TY Poussaint: "Variability in PET quantitation within a multicenter consortium." Med Phys. 37(7): 3660-6, 2010.
  • Kinahan, PE, KC Allberg, RK Doot, CM Lockhart, and W McDougald: "Calibration method and system for PET scanners." US Patent 7,858,925, 2010.
  • Doot, RK, JS Scheuermann, PE Christian, JS Karp, and PE Kinahan: "Instrumentation factors affecting variance and bias of quantifying tracer uptake with PET/CT." Med Phys. 37(11):6035-6046, 2010.