Publications

1: Lee TT, Bell BA, Anderson BD, Song Y, Dunaief JL. Tamoxifen protects
photoreceptors in the sodium iodate model. Exp Eye Res. 2024 May;242:109879.
doi: 10.1016/j.exer.2024.109879. Epub 2024 Apr 1. PMID: 38570182; PMCID:
PMC11055656.
2: Anderson BD, Lee TT, Bell BA, Wang T, Dunaief JL. Optimizing the sodium
iodate model: Effects of dose, gender, and age. Exp Eye Res. 2024
Feb;239:109772. doi: 10.1016/j.exer.2023.109772. Epub 2023 Dec 27. PMID:
38158173; PMCID: PMC10922497.
3: Anderson BD, Lee T, Bell B, Song Y, Dunaief JL. Low ceruloplasmin levels
exacerbate retinal degeneration in a hereditary hemochromatosis model. Dis Model
Mech. 2023 Jul 1;16(7):dmm050226. doi: 10.1242/dmm.050226. Epub 2023 Jul 13.
PMID: 37439255; PMCID: PMC10354715.
4: Zhang KR, Jankowski CSR, Marshall R, Nair R, Más Gómez N, Alnemri A, Liu Y,
Erler E, Ferrante J, Song Y, Bell BA, Baumann BH, Sterling J, Anderson B, Foshe
S, Roof J, Fazelinia H, Spruce LA, Chuang JZ, Sung CH, Dhingra A, Boesze-
Battaglia K, Chavali VRM, Rabinowitz JD, Mitchell CH, Dunaief JL. Oxidative
stress induces lysosomal membrane permeabilization and ceramide accumulation in
retinal pigment epithelial cells. Dis Model Mech. 2023 Jul 1;16(7):dmm050066.
doi: 10.1242/dmm.050066. Epub 2023 Jul 25. PMID: 37401371; PMCID: PMC10399446.
5: Sterling J, Hua P, Dunaief JL, Cui QN, VanderBeek BL. Glucagon-like peptide 1
receptor agonist use is associated with reduced risk for glaucoma. Br J
Ophthalmol. 2023 Feb;107(2):215-220. doi: 10.1136/bjophthalmol-2021-319232. Epub
2021 Aug 19. PMID: 34413054; PMCID: PMC8857286.
6: Bell BA, Kaul C, Dunaief JL, Hollyfield JG, Bonilha VL. A comparison of
optophysiological biomarkers of photoreceptor stress and phototoxicity in
BALB/cJ, B6 (Cg)-Tyrc-2J/J, and C57Bl/6J mouse strains. Front Ophthalmol
(Lausanne). 2023;3:1128311. doi: 10.3389/fopht.2023.1128311. Epub 2023 Mar 29.
PMID: 38689597; PMCID: PMC11057998.
7: Perzia B, Ying GS, Dunaief JL, Dunaief DM. Once-Daily Low Inflammatory Foods
Everyday (LIFE) Smoothie or the Full LIFE Diet Lowers C-Reactive Protein and
Raises Plasma Beta-Carotene in 7 Days. Am J Lifestyle Med. 2020 Oct
5;16(6):753-764. doi: 10.1177/1559827620962458. PMID: 36389047; PMCID:
PMC9644139.
8: Dunaief JL. Heavy lipids protect against heavy metals. Aging (Albany NY).
2022 Jun 22;14(12):4933-4934. doi: 10.18632/aging.204143. Epub 2022 Jun 22.
PMID: 35748784; PMCID: PMC9271310.
9: Sterling JK, Baumann B, Foshe S, Voigt A, Guttha S, Alnemri A, McCright SJ,
Li M, Zauhar RJ, Montezuma SR, Kapphahn RJ, Chavali VRM, Hill DA, Ferrington DA,
Stambolian D, Mullins RF, Merrick D, Dunaief JL. Inflammatory adipose activates
a nutritional immunity pathway leading to retinal dysfunction. Cell Rep. 2022
Jun 14;39(11):110942. doi: 10.1016/j.celrep.2022.110942. PMID: 35705048; PMCID:
PMC9248858.
10: Perzia BM, Ying GS, Dunaief JL, Dunaief DM. Reduction in Ferritin
Concentrations among Patients Consuming a Dark-Green Leafy Vegetable-Rich, Low
Inflammatory Foods Everyday (LIFE) Diet. Curr Dev Nutr. 2022 May
18;6(6):nzac095. doi: 10.1093/cdn/nzac095. PMID: 35769450; PMCID: PMC9233618.
11: Zhang KR, Baumann B, Song Y, Sterling J, Erler EA, Guttha S, Kozmik Z,
Dunaief JL. Conditional knockout of hephaestin in the neural retina disrupts
retinal iron homeostasis. Exp Eye Res. 2022 May;218:109028. doi:
10.1016/j.exer.2022.109028. Epub 2022 Mar 8. PMID: 35271829; PMCID: PMC9050911.
12: Liu Y, Baumann B, Song Y, Zhang K, Sterling JK, Lakhal-Littleton S, Kozmik
Z, Su G, Dunaief JL. Minimal effect of conditional ferroportin KO in the neural
retina implicates ferrous iron in retinal iron overload and degeneration. Exp
Eye Res. 2022 May;218:108988. doi: 10.1016/j.exer.2022.108988. Epub 2022 Feb 21.
PMID: 35202704; PMCID: PMC9050912.
13: Huang S, Liu CH, Wang Z, Fu Z, Britton WR, Blomfield AK, Kamenecka TM,
Dunaief JL, Solt LA, Chen J. REV-ERBα regulates age-related and oxidative
stress-induced degeneration in retinal pigment epithelium via NRF2. Redox Biol.
2022 May;51:102261. doi: 10.1016/j.redox.2022.102261. Epub 2022 Feb 9. PMID:
35176707; PMCID: PMC8851379.
14: Liu Y, Bell BA, Song Y, Zhang K, Anderson B, Axelsen PH, Bohannan W, Agbaga
MP, Park HG, James G, Brenna JT, Schmidt K, Dunaief JL, Shchepinov MS.
Deuterated docosahexaenoic acid protects against oxidative stress and geographic
atrophy-like retinal degeneration in a mouse model with iron overload. Aging
Cell. 2022 Apr;21(4):e13579. doi: 10.1111/acel.13579. Epub 2022 Mar 8. PMID:
35257475; PMCID: PMC9009113.
15: Guo M, Schwartz TD, Dunaief JL, Cui QN. Myeloid cells in retinal and brain
degeneration. FEBS J. 2022 Apr;289(8):2337-2361. doi: 10.1111/febs.16177. Epub
2021 Sep 15. PMID: 34478598; PMCID: PMC8891394.
16: Sterling JK, Kam TI, Guttha S, Park H, Baumann B, Mehrabani-Tabari AA,
Schultz H, Anderson B, Alnemri A, Chou SC, Troncoso JC, Dawson VL, Dawson TM,
Dunaief JL. Interleukin-6 triggers toxic neuronal iron sequestration in response
to pathological α-synuclein. Cell Rep. 2022 Feb 15;38(7):110358. doi:
10.1016/j.celrep.2022.110358. PMID: 35172141; PMCID: PMC8898592.
17: Chuang JZ, Yang N, Nakajima N, Otsu W, Fu C, Yang HH, Lee MP, Akbar AF,
Badea TC, Guo Z, Nuruzzaman A, Hsu KS, Dunaief JL, Sung CH. Retinal pigment
epithelium-specific CLIC4 mutant is a mouse model of dry age-related macular
degeneration. Nat Commun. 2022 Jan 18;13(1):374. doi:
10.1038/s41467-021-27935-9. PMID: 35042858; PMCID: PMC8766482.
18: Perzia BM, Dunaief JL, Dunaief DM. Chronic migraine reversal and prevention
with the LIFE diet: a nutrient dense whole food plant-based diet (WFPBD). BMJ
Case Rep. 2021 Nov 18;14(12):e243987. doi: 10.1136/bcr-2021-243987. PMID:
34794983; PMCID: PMC8689122.
19: Kim BJ, Lee V, Lee EB, Saludades A, Trojanowski JQ, Dunaief JL, Grossman M,
Irwin DJ. Retina tissue validation of optical coherence tomography determined
outer nuclear layer loss in FTLD-tau. Acta Neuropathol Commun. 2021 Nov
18;9(1):184. doi: 10.1186/s40478-021-01290-8. PMID: 34794500; PMCID: PMC8600822.
20: Schultz H, Ying GS, Dunaief JL, Dunaief DM. Rising Plasma Beta-Carotene Is
Associated With Diminishing C-Reactive Protein in Patients Consuming a Dark
Green Leafy Vegetable-Rich, Low Inflammatory Foods Everyday (LIFE) Diet. Am J
Lifestyle Med. 2019 Dec 21;15(6):634-643. doi: 10.1177/1559827619894954. PMID:
34916884; PMCID: PMC8669909.
21: Liu Y, Bell BA, Song Y, Kim HJ, Sterling JK, Kim BJ, Poli M, Guo M, Zhang K,
Rao A, Sparrow JR, Su G, Dunaief JL. Intraocular iron injection induces
oxidative stress followed by elements of geographic atrophy and sympathetic
ophthalmia. Aging Cell. 2021 Nov;20(11):e13490. doi: 10.1111/acel.13490. Epub
2021 Oct 9. PMID: 34626070; PMCID: PMC8590099.
22: Song D, Hua P, VanderBeek BL, Dunaief JL, Grunwald JE, Daniel E, Maguire MG,
Martin DF, Ying GS; CATT Research Group. SYSTEMIC MEDICATION USE AND THE
INCIDENCE AND GROWTH OF GEOGRAPHIC ATROPHY IN THE COMPARISON OF AGE-RELATED
MACULAR DEGENERATION TREATMENTS TRIALS. Retina. 2021 Jul 1;41(7):1455-1462. doi:
10.1097/IAE.0000000000003075. PMID: 33332813; PMCID: PMC9296271.
23: Kim BJ, Mastellos DC, Li Y, Dunaief JL, Lambris JD. Targeting complement
components C3 and C5 for the retina: Key concepts and lingering questions. Prog
Retin Eye Res. 2021 Jul;83:100936. doi: 10.1016/j.preteyeres.2020.100936. Epub
2020 Dec 13. PMID: 33321207; PMCID: PMC8197769.
24: Zhao J, Kim HJ, Ueda K, Zhang K, Montenegro D, Dunaief JL, Sparrow JR. A
vicious cycle of bisretinoid formation and oxidation relevant to recessive
Stargardt disease. J Biol Chem. 2021 Jan 5:jbc.RA120.015890. doi:
10.1074/jbc.RA120.015890. Epub ahead of print. PMID: 33402423.
25: Zhao J, Kim HJ, Ueda K, Zhang K, Montenegro D, Dunaief JL, Sparrow JR. A
vicious cycle of bisretinoid formation and oxidation relevant to recessive
Stargardt disease. J Biol Chem. 2021 Jan-Jun;296:100259. doi:
10.1016/j.jbc.2021.100259. Epub 2021 Jan 7. PMID: 33837742; PMCID: PMC7948646.
26: Sterling JK, Adetunji MO, Guttha S, Bargoud AR, Uyhazi KE, Ross AG, Dunaief
JL, Cui QN. GLP-1 Receptor Agonist NLY01 Reduces Retinal Inflammation and Neuron
Death Secondary to Ocular Hypertension. Cell Rep. 2020 Nov 3;33(5):108271. doi:
10.1016/j.celrep.2020.108271. PMID: 33147455; PMCID: PMC7660987.
27: Kim BJ, Hunter A, Brucker AJ, Hahn P, Gehrs K, Patel A, Edwards AO, Li Y,
Khurana RN, Nissim I, Daniel E, Grunwald J, Ying GS, Pistilli M, Maguire MG,
Dunaief JL. Orally Administered Alpha Lipoic Acid as a Treatment for Geographic
Atrophy: A Randomized Clinical Trial. Ophthalmol Retina. 2020 Sep;4(9):889-898.
doi: 10.1016/j.oret.2020.03.019. Epub 2020 Apr 2. PMID: 32418846; PMCID:
PMC7483261.
28: Shu W, Baumann BH, Song Y, Liu Y, Wu X, Dunaief JL. Ferrous but not ferric
iron sulfate kills photoreceptors and induces photoreceptor-dependent RPE
autofluorescence. Redox Biol. 2020 Jul;34:101469. doi:
10.1016/j.redox.2020.101469. Epub 2020 Apr 18. PMID: 32362442; PMCID:
PMC7327978.
29: Bellsmith KN, Dunaief JL, Yang P, Pennesi ME, Davis E, Hofkamp H, Lujan BJ.
Bull's eye maculopathy associated with hereditary hemochromatosis. Am J
Ophthalmol Case Rep. 2020 Mar 20;18:100674. doi: 10.1016/j.ajoc.2020.100674.
PMID: 32258826; PMCID: PMC7109569.
30: Hughes S, Gumas J, Lee R, Rumano M, Berger N, Gautam AK, Sfyroera G, Chan
AL, Gnanaguru G, Connor KM, Kim BJ, Dunaief JL, Ricklin D, Hajishengallis G,
Yancopoulou D, Reis ES, Mastellos DC, Lambris JD. Prolonged intraocular
residence and retinal tissue distribution of a fourth-generation compstatin-
based C3 inhibitor in non-human primates. Clin Immunol. 2020 May;214:108391.
doi: 10.1016/j.clim.2020.108391. Epub 2020 Mar 27. PMID: 32229292; PMCID:
PMC7368884.
31: Cui QN, Bargoud AR, Ross AG, Song Y, Dunaief JL. Oral administration of the
iron chelator deferiprone protects against loss of retinal ganglion cells in a
mouse model of glaucoma. Exp Eye Res. 2020 Apr;193:107961. doi:
10.1016/j.exer.2020.107961. Epub 2020 Feb 8. PMID: 32045598; PMCID: PMC7584350.
32: Klee K, Storti F, Barben M, Samardzija M, Langmann T, Dunaief J, Grimm C.
Systemic knockout of Tspo in mice does not affect retinal morphology, function
and susceptibility to degeneration. Exp Eye Res. 2019 Nov;188:107816. doi:
10.1016/j.exer.2019.107816. Epub 2019 Sep 25. PMID: 31562844.
33: Shu W, Baumann BH, Song Y, Liu Y, Wu X, Dunaief JL. Iron Accumulates in
Retinal Vascular Endothelial Cells But Has Minimal Retinal Penetration After IP
Iron Dextran Injection in Mice. Invest Ophthalmol Vis Sci. 2019 Oct
1;60(13):4378-4387. doi: 10.1167/iovs.19-28250. PMID: 31634395; PMCID:
PMC6798310.
34: Baumann BH, Shu W, Song Y, Simpson EM, Lakhal-Littleton S, Dunaief JL.
Ferroportin-mediated iron export from vascular endothelial cells in retina and
brain. Exp Eye Res. 2019 Oct;187:107728. doi: 10.1016/j.exer.2019.107728. Epub
2019 Jul 16. PMID: 31323276; PMCID: PMC6759385.
35: Hussnain SA, Dolz-Marco R, Dunaief JL, Curcio CA, Freund KB. SPECKLED
HYPOAUTOFLUORESCENCE AS A SIGN OF RESOLVED SUBRETINAL HEMORRHAGE IN NEOVASCULAR
AGE-RELATED MACULAR DEGENERATION. Retina. 2019 Oct;39(10):1925-1935. doi:
10.1097/IAE.0000000000002367. PMID: 30355956; PMCID: PMC6476706.
36: Song D, Ying GS, Dunaief JL, Bhuyan R, Li Y, Maguire MG, Grunwald JE, Daniel
E, Hagstrom S, Martin DF; Comparison of Age-Related Macular Degeneration
Treatment Trial Research Group. ASSOCIATION BETWEEN ORAL IRON SUPPLEMENTATION
AND RETINAL OR SUBRETINAL HEMORRHAGE IN THE COMPARISON OF AGE-RELATED MACULAR
DEGENERATION TREATMENT TRIALS. Retina. 2019 Oct;39(10):1965-1972. doi:
10.1097/IAE.0000000000002295. PMID: 30157115; PMCID: PMC6395574.
37: Baumann BH, Shu W, Song Y, Sterling J, Kozmik Z, Lakhal-Littleton S, Dunaief
JL. Liver-Specific, but Not Retina-Specific, Hepcidin Knockout Causes Retinal
Iron Accumulation and Degeneration. Am J Pathol. 2019 Sep;189(9):1814-1830. doi:
10.1016/j.ajpath.2019.05.022. Epub 2019 Jul 6. PMID: 31287995; PMCID:
PMC6723216.
38: Schultz H, Song Y, Baumann BH, Kapphahn RJ, Montezuma SR, Ferrington DA,
Dunaief JL. Increased serum proteins in non-exudative AMD retinas. Exp Eye Res.
2019 Sep;186:107686. doi: 10.1016/j.exer.2019.05.026. Epub 2019 May 31. PMID:
31158383; PMCID: PMC6703940.
39: Khan RS, Baumann B, Dine K, Song Y, Dunaief JL, Kim SF, Shindler KS. Dexras1
Deletion and Iron Chelation Promote Neuroprotection in Experimental Optic
Neuritis. Sci Rep. 2019 Aug 12;9(1):11664. doi: 10.1038/s41598-019-48087-3.
PMID: 31406150; PMCID: PMC6690882.
40: Chen Z, Jiang R, Chen M, Zheng J, Chen M, Braidy N, Liu S, Liu G,
Maimaitiming Z, Shen T, Dunaief JL, Vulpe CD, Anderson GJ, Chen H. Multi-copper
ferroxidase deficiency leads to iron accumulation and oxidative damage in
astrocytes and oligodendrocytes. Sci Rep. 2019 Jul 1;9(1):9437. doi:
10.1038/s41598-019-46019-9. PMID: 31263155; PMCID: PMC6603037.
41: Ueda Y, Miwa T, Ito D, Kim H, Sato S, Gullipalli D, Zhou L, Golla M, Song D,
Dunaief JL, Palmer MB, Song WC. Differential contribution of C5aR and C5b-9
pathways to renal thrombic microangiopathy and macrovascular thrombosis in mice
carrying an atypical hemolytic syndrome-related factor H mutation. Kidney Int.
2019 Jul;96(1):67-79. doi: 10.1016/j.kint.2019.01.009. Epub 2019 Feb 27. PMID:
30910380; PMCID: PMC10084839.
42: Daniel E, Ying GS, Kim BJ, Toth CA, Ferris F 3rd, Martin DF, Grunwald JE,
Jaffe GJ, Dunaief JL, Pan W, Maguire MG; Comparison of Age-Related Macular
Degeneration Treatments Trials. Five-Year Follow-up of Nonfibrotic Scars in the
Comparison of Age-Related Macular Degeneration Treatments Trials. Ophthalmology.
2019 May;126(5):743-751. doi: 10.1016/j.ophtha.2018.11.020. Epub 2018 Nov 23.
PMID: 30476517; PMCID: PMC6475610.
43: Kim BJ, Grossman M, Song D, Saludades S, Pan W, Dominguez-Perez S, Dunaief
JL, Aleman TS, Ying GS, Irwin DJ. Persistent and Progressive Outer Retina
Thinning in Frontotemporal Degeneration. Front Neurosci. 2019 Apr 4;13:298. doi:
10.3389/fnins.2019.00298. PMID: 31019447; PMCID: PMC6459211.
44: Song D, Ueda Y, Bhuyan R, Mohammed I, Miwa T, Gullipali D, Kim H, Zhou L,
Song Y, Schultz H, Bargoud A, Dunaief JL, Song WC. Complement Factor H Mutation
W1206R Causes Retinal Thrombosis and Ischemic Retinopathy in Mice. Am J Pathol.
2019 Apr;189(4):826-838. doi: 10.1016/j.ajpath.2019.01.009. Epub 2019 Feb 1.
PMID: 30711487; PMCID: PMC6458521.
45: Badiei A, Sudharsan R, Santana E, Dunaief JL, Aguirre GD. Comparative
localization of cystathionine beta synthases and cystathionine gamma lyase in
canine, non-human primate and human retina. Exp Eye Res. 2019 Apr;181:72-84.
doi: 10.1016/j.exer.2019.01.007. Epub 2019 Jan 14. PMID: 30653965; PMCID:
PMC6443508.
46: Storti F, Klee K, Todorova V, Steiner R, Othman A, van der Velde-Visser S,
Samardzija M, Meneau I, Barben M, Karademir D, Pauzuolyte V, Boye SL, Blaser F,
Ullmer C, Dunaief JL, Hornemann T, Rohrer L, den Hollander A, von Eckardstein A,
Fingerle J, Maugeais C, Grimm C. Impaired ABCA1/ABCG1-mediated lipid efflux in
the mouse retinal pigment epithelium (RPE) leads to retinal degeneration. Elife.
2019 Mar 13;8:e45100. doi: 10.7554/eLife.45100. PMID: 30864945; PMCID:
PMC6435327.
47: Yu JJ, Agrón E, Clemons TE, Domalpally A, van Asten F, Keenan TD, Cukras C,
Chew EY; Age-Related Eye Disease Study 2 Research Group. Natural History of
Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular
Degeneration: Age-Related Eye Disease Study 2 Report No. 17. Ophthalmology. 2019
Feb;126(2):261-273. doi: 10.1016/j.ophtha.2018.08.017. Epub 2018 Aug 22. PMID:
30142373; PMCID: PMC6348044.
48: Storm T, Burgoyne T, Dunaief JL, Christensen EI, Futter C, Nielsen R.
Selective Ablation of Megalin in the Retinal Pigment Epithelium Results in
Megaophthalmos, Macromelanosome Formation and Severe Retina Degeneration. Invest
Ophthalmol Vis Sci. 2019 Jan 2;60(1):322-330. doi: 10.1167/iovs.18-25667. PMID:
30665232; PMCID: PMC6343679.
49: Saadane A, Petrov A, Mast N, El-Darzi N, Dao T, Alnemri A, Song Y, Dunaief
JL, Pikuleva IA. Mechanisms that minimize retinal impact of apolipoprotein E
absence. J Lipid Res. 2018 Dec;59(12):2368-2382. doi: 10.1194/jlr.M090043. Epub
2018 Oct 17. PMID: 30333155; PMCID: PMC6277162.
50: Keenan TD, Agrón E, Domalpally A, Clemons TE, van Asten F, Wong WT, Danis
RG, Sadda S, Rosenfeld PJ, Klein ML, Ratnapriya R, Swaroop A, Ferris FL 3rd,
Chew EY; AREDS2 Research Group. Progression of Geographic Atrophy in Age-related
Macular Degeneration: AREDS2 Report Number 16. Ophthalmology. 2018
Dec;125(12):1913-1928. doi: 10.1016/j.ophtha.2018.05.028. Epub 2018 Jul 27.
PMID: 30060980; PMCID: PMC6246813.
51: Shu W, Dunaief JL. Potential Treatment of Retinal Diseases with Iron
Chelators. Pharmaceuticals (Basel). 2018 Oct 22;11(4):112. doi:
10.3390/ph11040112. PMID: 30360383; PMCID: PMC6316536.
52: Song D, Mohammed I, Bhuyan R, Miwa T, Williams AL, Gullipalli D, Sato S,
Song Y, Dunaief JL, Song WC. Retinal Basal Laminar Deposits in Complement fH/fP
Mouse Model of Dense Deposit Disease. Invest Ophthalmol Vis Sci. 2018 Jul
2;59(8):3405-3415. doi: 10.1167/iovs.18-24133. PMID: 30025090; PMCID:
PMC6040236.
53: Fuqua BK, Lu Y, Frazer DM, Darshan D, Wilkins SJ, Dunn L, Loguinov AV, Kogan
SC, Matak P, Chen H, Dunaief JL, Vulpe CD, Anderson GJ. Severe Iron Metabolism
Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin
and Ceruloplasmin. Cell Mol Gastroenterol Hepatol. 2018 Jun 23;6(4):405-427.
doi: 10.1016/j.jcmgh.2018.06.006. PMID: 30182051; PMCID: PMC6120670.
54: Ueda K, Kim HJ, Zhao J, Song Y, Dunaief JL, Sparrow JR. Iron promotes
oxidative cell death caused by bisretinoids of retina. Proc Natl Acad Sci U S A.
2018 May 8;115(19):4963-4968. doi: 10.1073/pnas.1722601115. Epub 2018 Apr 23.
PMID: 29686088; PMCID: PMC5948992.
55: Zheng J, Jiang R, Chen M, Maimaitiming Z, Wang J, Anderson GJ, Vulpe CD,
Dunaief JL, Chen H. Multi-Copper Ferroxidase-Deficient Mice Have Increased Brain
Iron Concentrations and Learning and Memory Deficits. J Nutr. 2018 Apr
1;148(4):643-649. doi: 10.1093/jn/nxy012. PMID: 29659961.
56: Kim BJ, Irwin DJ, Song D, Daniel E, Leveque JD, Raquib AR, Pan W, Ying GS,
Aleman TS, Dunaief JL, Grossman M. Optical coherence tomography identifies outer
retina thinning in frontotemporal degeneration. Neurology. 2017 Oct
10;89(15):1604-1611. doi: 10.1212/WNL.0000000000004500. Epub 2017 Sep 8. PMID:
28887373; PMCID: PMC5634666.
57: Baumann B, Sterling J, Song Y, Song D, Fruttiger M, Gillies M, Shen W,
Dunaief JL. Conditional Müller Cell Ablation Leads to Retinal Iron Accumulation.
Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4223-4234. doi:
10.1167/iovs.17-21743. PMID: 28846772; PMCID: PMC5574447.
58: Song D, Sulewski ME Jr, Wang C, Song J, Bhuyan R, Sterling J, Clark E, Song
WC, Dunaief JL. Complement C5a receptor knockout has diminished light-induced
microglia/macrophage retinal migration. Mol Vis. 2017 Apr 10;23:210-218. PMID:
28442885; PMCID: PMC5389337.
59: Qi S, Wang C, Song D, Song Y, Dunaief JL. Intraperitoneal injection of
(-)-Epigallocatechin-3-gallate protects against light-induced photoreceptor
degeneration in the mouse retina. Mol Vis. 2017 Mar 24;23:171-178. PMID:
28458506; PMCID: PMC5367892.
60: Ueda Y, Mohammed I, Song D, Gullipalli D, Zhou L, Sato S, Wang Y, Gupta S,
Cheng Z, Wang H, Bao J, Mao Y, Brass L, Zheng XL, Miwa T, Palmer M, Dunaief J,
Song WC. Murine systemic thrombophilia and hemolytic uremic syndrome from a
factor H point mutation. Blood. 2017 Mar 2;129(9):1184-1196. doi:
10.1182/blood-2016-07-728253. Epub 2017 Jan 5. PMID: 28057640; PMCID:
PMC5374733.
61: Sterling J, Guttha S, Song Y, Song D, Hadziahmetovic M, Dunaief JL. Iron
importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron
levels. Exp Eye Res. 2017 Feb;155:15-23. doi: 10.1016/j.exer.2016.12.008. Epub
2017 Jan 3. PMID: 28057442; PMCID: PMC5359041.
62: Jiang B, Liu G, Zheng J, Chen M, Maimaitiming Z, Chen M, Liu S, Jiang R,
Fuqua BK, Dunaief JL, Vulpe CD, Anderson GJ, Wang H, Chen H. Hephaestin and
ceruloplasmin facilitate iron metabolism in the mouse kidney. Sci Rep. 2016 Dec
19;6:39470. doi: 10.1038/srep39470. PMID: 27991585; PMCID: PMC5171654.
63: Song D, Wilson B, Zhao L, Bhuyan R, Bandyopadhyay M, Lyubarsky A, Yu C, Li
Y, Kanu L, Miwa T, Song WC, Finnemann SC, Rohrer B, Dunaief JL. Retinal Pre-
Conditioning by CD59a Knockout Protects against Light-Induced Photoreceptor
Degeneration. PLoS One. 2016 Nov 28;11(11):e0166348. doi:
10.1371/journal.pone.0166348. PMID: 27893831; PMCID: PMC5125596.
64: Song D, Kanu LN, Li Y, Kelly KL, Bhuyan RK, Aleman T, Morgan JI, Dunaief JL.
AMD-like retinopathy associated with intravenous iron. Exp Eye Res. 2016
Oct;151:122-33. doi: 10.1016/j.exer.2016.08.008. Epub 2016 Aug 23. PMID:
27565570; PMCID: PMC5045814.
65: Sarezky D, Raquib AR, Dunaief JL, Kim BJ. Tolerability in the elderly
population of high-dose alpha lipoic acid: a potential antioxidant therapy for
the eye. Clin Ophthalmol. 2016 Sep 29;10:1899-1903. doi: 10.2147/OPTH.S115900.
PMID: 27729766; PMCID: PMC5047711.
66: Dunaief JL. RACking Up Retinal Oxidative Stress. Invest Ophthalmol Vis Sci.
2016 May 1;57(6):2876. doi: 10.1167/iovs.16-19764. PMID: 27233036.
67: AREDS2 Research Group; Al-Holou SN, Tucker WR, Agrón E, Clemons TE, Sperduto
RD, Ferris FL 3rd, Chew EY. The Association of Statin Use with Cataract
Progression and Cataract Surgery: The AREDS2 Report Number 8. Ophthalmology.
2016 Apr;123(4):916-7. doi: 10.1016/j.ophtha.2015.10.040. Epub 2015 Dec 11.
PMID: 26686966; PMCID: PMC4808327.
68: Song D, Song J, Wang C, Li Y, Dunaief JL. Berberine protects against light-
induced photoreceptor degeneration in the mouse retina. Exp Eye Res. 2016
Apr;145:1-9. doi: 10.1016/j.exer.2015.10.005. Epub 2015 Oct 22. PMID: 26475979;
PMCID: PMC4841753.
69: Theurl M, Song D, Clark E, Sterling J, Grieco S, Altamura S, Galy B, Hentze
M, Muckenthaler MU, Dunaief JL. Mice with hepcidin-resistant ferroportin
accumulate iron in the retina. FASEB J. 2016 Feb;30(2):813-23. doi:
10.1096/fj.15-276758. Epub 2015 Oct 27. PMID: 26506980; PMCID: PMC4714557.
70: Bhoiwala DL, Dunaief JL. Retinal abnormalities in β-thalassemia major. Surv
Ophthalmol. 2016 Jan-Feb;61(1):33-50. doi: 10.1016/j.survophthal.2015.08.005.
Epub 2015 Aug 29. PMID: 26325202; PMCID: PMC4690783.
71: Hunter AA 3rd, Smit-McBride Z, Anderson R, Bordbari MH, Ying GS, Kim ES,
Park SS, Telander DG, Dunaief JL, Hjelmeland LM, Morse LS. GSTM1 and GSTM5
Genetic Polymorphisms and Expression in Age-Related Macular Degeneration. Curr
Eye Res. 2016;41(3):410-6. doi: 10.3109/02713683.2015.1016179. Epub 2015 Apr 21.
PMID: 25897651; PMCID: PMC4972491.
72: Zhao L, Hadziahmetovic M, Wang C, Xu X, Song Y, Jinnah HA, Wodzinska J,
Iacovelli J, Wolkow N, Krajacic P, Weissberger AC, Connelly J, Spino M, Lee MK,
Connor J, Giasson B, Harris ZL, Dunaief JL. Cp/Heph mutant mice have iron-
induced neurodegeneration diminished by deferiprone. J Neurochem. 2015
Dec;135(5):958-74. doi: 10.1111/jnc.13292. Epub 2015 Sep 29. PMID: 26303407;
PMCID: PMC4943332.
73: Bhoiwala DL, Song Y, Cwanger A, Clark E, Zhao LL, Wang C, Li Y, Song D,
Dunaief JL. CD1 Mouse Retina Is Shielded From Iron Overload Caused by a High
Iron Diet. Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5344-52. doi:
10.1167/iovs.15-17026. PMID: 26275132; PMCID: PMC4539129.
74: Gelfand BD, Wright CB, Kim Y, Yasuma T, Yasuma R, Li S, Fowler BJ, Bastos-
Carvalho A, Kerur N, Uittenbogaard A, Han YS, Lou D, Kleinman ME, McDonald WH,
Núñez G, Georgel P, Dunaief JL, Ambati J. Iron Toxicity in the Retina Requires
Alu RNA and the NLRP3 Inflammasome. Cell Rep. 2015 Jun 23;11(11):1686-93. doi:
10.1016/j.celrep.2015.05.023. Epub 2015 Jun 11. PMID: 26074074; PMCID:
PMC4481133.
75: Li Y, Song D, Song Y, Zhao L, Wolkow N, Tobias JW, Song W, Dunaief JL. Iron-
induced Local Complement Component 3 (C3) Up-regulation via Non-canonical
Transforming Growth Factor (TGF)-β Signaling in the Retinal Pigment Epithelium.
J Biol Chem. 2015 May 8;290(19):11918-34. doi: 10.1074/jbc.M115.645903. Epub
2015 Mar 23. PMID: 25802332; PMCID: PMC4424331.
76: Choi SY, Baek JI, Zuo X, Kim SH, Dunaief JL, Lipschutz JH. Cdc42 and sec10
Are Required for Normal Retinal Development in Zebrafish. Invest Ophthalmol Vis
Sci. 2015 May;56(5):3361-70. doi: 10.1167/iovs.14-15692. PMID: 26024121; PMCID:
PMC4453986.
77: Jiang R, Hua C, Wan Y, Jiang B, Hu H, Zheng J, Fuqua BK, Dunaief JL,
Anderson GJ, David S, Vulpe CD, Chen H. Hephaestin and ceruloplasmin play
distinct but interrelated roles in iron homeostasis in mouse brain. J Nutr. 2015
May;145(5):1003-9. doi: 10.3945/jn.114.207316. Epub 2015 Mar 18. PMID: 25788583.
78: Yao J, Jia L, Khan N, Lin C, Mitter SK, Boulton ME, Dunaief JL, Klionsky DJ,
Guan JL, Thompson DA, Zacks DN. Deletion of autophagy inducer RB1CC1 results in
degeneration of the retinal pigment epithelium. Autophagy. 2015;11(6):939-53.
doi: 10.1080/15548627.2015.1041699. PMID: 26075877; PMCID: PMC4502815.
79: Guo LY, Alekseev O, Li Y, Song Y, Dunaief JL. Iron increases APP translation
and amyloid-beta production in the retina. Exp Eye Res. 2014 Dec;129:31-7. doi:
10.1016/j.exer.2014.10.012. Epub 2014 Oct 16. PMID: 25456519; PMCID: PMC4259833.
80: Wolkow N, Li Y, Maminishkis A, Song Y, Alekseev O, Iacovelli J, Song D, Lee
JC, Dunaief JL. Iron upregulates melanogenesis in cultured retinal pigment
epithelial cells. Exp Eye Res. 2014 Nov;128:92-101. doi:
10.1016/j.exer.2014.09.010. Epub 2014 Sep 30. PMID: 25277027; PMCID: PMC4252790.
81: Zhao L, Li Y, Song D, Song Y, Theurl M, Wang C, Cwanger A, Su G, Dunaief JL.
A high serum iron level causes mouse retinal iron accumulation despite an intact
blood-retinal barrier. Am J Pathol. 2014 Nov;184(11):2862-7. doi:
10.1016/j.ajpath.2014.07.008. Epub 2014 Aug 28. PMID: 25174877; PMCID:
PMC4215029.
82: Song D, Grieco S, Li Y, Hunter A, Chu S, Zhao L, Song Y, DeAngelis RA, Shi
LY, Liu Q, Pierce EA, Nishina PM, Lambris JD, Dunaief JL. A murine RP1 missense
mutation causes protein mislocalization and slowly progressive photoreceptor
degeneration. Am J Pathol. 2014 Oct;184(10):2721-9. doi:
10.1016/j.ajpath.2014.06.010. Epub 2014 Aug 1. PMID: 25088982; PMCID:
PMC4188862.
83: Zhao L, Wang C, Song D, Li Y, Song Y, Su G, Dunaief JL. Systemic
administration of the antioxidant/iron chelator α-lipoic acid protects against
light-induced photoreceptor degeneration in the mouse retina. Invest Ophthalmol
Vis Sci. 2014 Aug 21;55(9):5979-88. doi: 10.1167/iovs.14-15025. PMID: 25146987;
PMCID: PMC4172298.
84: Song D, Zhao L, Li Y, Hadziahmetovic M, Song Y, Connelly J, Spino M, Dunaief
JL. The oral iron chelator deferiprone protects against systemic iron overload-
induced retinal degeneration in hepcidin knockout mice. Invest Ophthalmol Vis
Sci. 2014 Jun 26;55(7):4525-32. doi: 10.1167/iovs.14-14568. PMID: 24970260;
PMCID: PMC4106252.
85: Fuqua BK, Lu Y, Darshan D, Frazer DM, Wilkins SJ, Wolkow N, Bell AG, Hsu J,
Yu CC, Chen H, Dunaief JL, Anderson GJ, Vulpe CD. The multicopper ferroxidase
hephaestin enhances intestinal iron absorption in mice. PLoS One. 2014 Jun
4;9(6):e98792. doi: 10.1371/journal.pone.0098792. PMID: 24896847; PMCID:
PMC4045767.
86: He L, Marioutina M, Dunaief JL, Marneros AG. Age- and gene-dosage-dependent
cre-induced abnormalities in the retinal pigment epithelium. Am J Pathol. 2014
Jun;184(6):1660-7. doi: 10.1016/j.ajpath.2014.02.007. PMID: 24854863; PMCID:
PMC4044719.
87: Masuda T, Wahlin K, Wan J, Hu J, Maruotti J, Yang X, Iacovelli J, Wolkow N,
Kist R, Dunaief JL, Qian J, Zack DJ, Esumi N. Transcription factor SOX9 plays a
key role in the regulation of visual cycle gene expression in the retinal
pigment epithelium. J Biol Chem. 2014 May 2;289(18):12908-21. doi:
10.1074/jbc.M114.556738. Epub 2014 Mar 14. PMID: 24634209; PMCID: PMC4007478.
88: Danis RP, Domalpally A, Chew EY, Clemons TE, Armstrong J, SanGiovanni JP,
Ferris FL 3rd; AREDS2 Study Group. Methods and reproducibility of grading
optimized digital color fundus photographs in the Age-Related Eye Disease Study
2 (AREDS2 Report Number 2). Invest Ophthalmol Vis Sci. 2013 Jul 8;54(7):4548-54.
doi: 10.1167/iovs.13-11804. PMID: 23620429; PMCID: PMC3706107.
89: Song D, Dunaief JL. Retinal iron homeostasis in health and disease. Front
Aging Neurosci. 2013 Jun 28;5:24. doi: 10.3389/fnagi.2013.00024. PMID: 23825457;
PMCID: PMC3695389.
90: Chen Y, Khan RS, Cwanger A, Song Y, Steenstra C, Bang S, Cheah JH, Dunaief
J, Shindler KS, Snyder SH, Kim SF. Dexras1, a small GTPase, is required for
glutamate-NMDA neurotoxicity. J Neurosci. 2013 Feb 20;33(8):3582-7. doi:
10.1523/JNEUROSCI.1497-12.2013. PMID: 23426685; PMCID: PMC3711661.
91: Hadziahmetovic M, Pajic M, Grieco S, Song Y, Song D, Li Y, Cwanger A,
Iacovelli J, Chu S, Ying GS, Connelly J, Spino M, Dunaief JL. The Oral Iron
Chelator Deferiprone Protects Against Retinal Degeneration Induced through
Diverse Mechanisms. Transl Vis Sci Technol. 2012 Oct 25;1(3):2. doi:
10.1167/tvst.1.3.2. PMID: 24049709; PMCID: PMC3763884.
92: Hadziahmetovic M, Pajic M, Grieco S, Song Y, Song D, Li Y, Cwanger A,
Iacovelli J, Chu S, Ying GS, Connelly J, Spino M, Dunaief JL. The Oral Iron
Chelator Deferiprone Protects Against Retinal Degeneration Induced through
Diverse Mechanisms. Transl Vis Sci Technol. 2012 Sep 28;1(2):7. doi:
10.1167/tvst.1.2.7. PMID: 24049707; PMCID: PMC3763881.
93: Hadziahmetovic M, Kumar U, Song Y, Grieco S, Song D, Li Y, Tobias JW,
Dunaief JL. Microarray analysis of murine retinal light damage reveals changes
in iron regulatory, complement, and antioxidant genes in the neurosensory retina
and isolated RPE. Invest Ophthalmol Vis Sci. 2012 Aug 7;53(9):5231-41. doi:
10.1167/iovs.12-10204. PMID: 22736611; PMCID: PMC4159963.
94: Song D, Song Y, Hadziahmetovic M, Zhong Y, Dunaief JL. Systemic
administration of the iron chelator deferiprone protects against light-induced
photoreceptor degeneration in the mouse retina. Free Radic Biol Med. 2012 Jul
1;53(1):64-71. doi: 10.1016/j.freeradbiomed.2012.04.020. Epub 2012 May 1. PMID:
22579919; PMCID: PMC3380452.
95: Tarallo V, Hirano Y, Gelfand BD, Dridi S, Kerur N, Kim Y, Cho WG, Kaneko H,
Fowler BJ, Bogdanovich S, Albuquerque RJ, Hauswirth WW, Chiodo VA, Kugel JF,
Goodrich JA, Ponicsan SL, Chaudhuri G, Murphy MP, Dunaief JL, Ambati BK, Ogura
Y, Yoo JW, Lee DK, Provost P, Hinton DR, Núñez G, Baffi JZ, Kleinman ME, Ambati
J. DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3
inflammasome and MyD88. Cell. 2012 May 11;149(4):847-59. doi:
10.1016/j.cell.2012.03.036. Epub 2012 Apr 26. PMID: 22541070; PMCID: PMC3351582.
96: Hunter A, Spechler PA, Cwanger A, Song Y, Zhang Z, Ying GS, Hunter AK,
Dezoeten E, Dunaief JL. DNA methylation is associated with altered gene
expression in AMD. Invest Ophthalmol Vis Sci. 2012 Apr 24;53(4):2089-105. doi:
10.1167/iovs.11-8449. PMID: 22410570; PMCID: PMC4108280.
97: Wolkow N, Song D, Song Y, Chu S, Hadziahmetovic M, Lee JC, Iacovelli J,
Grieco S, Dunaief JL. Ferroxidase hephaestin's cell-autonomous role in the
retinal pigment epithelium. Am J Pathol. 2012 Apr;180(4):1614-24. doi:
10.1016/j.ajpath.2011.12.041. Epub 2012 Feb 17. PMID: 22342521; PMCID:
PMC3349827.
98: Mehta S, Bunya VY, Orlin SE, Sulewski ME, Dunaief JL. A significant drug-
drug interaction detected through corneal examination: resolution of cornea
verticillata while using amiodarone. Cornea. 2012 Jan;31(1):81-3. doi:
10.1097/ICO.0b013e3182107c8e. PMID: 21941175.
99: Wolkow N, Song Y, Wu TD, Qian J, Guerquin-Kern JL, Dunaief JL.
Aceruloplasminemia: retinal histopathologic manifestations and iron-mediated
melanosome degradation. Arch Ophthalmol. 2011 Nov;129(11):1466-74. doi:
10.1001/archophthalmol.2011.309. PMID: 22084216; PMCID: PMC4089978.
100: Dunaief JL. Ironing out neurodegeneration: iron chelation for
neuroprotection. Free Radic Biol Med. 2011 Oct 15;51(8):1480-1. doi:
10.1016/j.freeradbiomed.2011.05.009. Epub 2011 May 14. PMID: 21616141; PMCID:
PMC4380125.
101: Leed MG, Wolkow N, Pham DM, Daniel CL, Dunaief JL, Franz KJ. Prochelators
triggered by hydrogen peroxide provide hexadentate iron coordination to impede
oxidative stress. J Inorg Biochem. 2011 Sep;105(9):1161-72. doi:
10.1016/j.jinorgbio.2011.05.023. Epub 2011 Jun 12. PMID: 21708101; PMCID:
PMC3355344.
102: Hadziahmetovic M, Song Y, Wolkow N, Iacovelli J, Kautz L, Roth MP, Dunaief
JL. Bmp6 regulates retinal iron homeostasis and has altered expression in age-
related macular degeneration. Am J Pathol. 2011 Jul;179(1):335-48. doi:
10.1016/j.ajpath.2011.03.033. Epub 2011 May 3. PMID: 21703414; PMCID:
PMC3123855.
103: Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME,
Ponicsan SL, Hauswirth WW, Chiodo VA, Karikó K, Yoo JW, Lee DK, Hadziahmetovic
M, Song Y, Misra S, Chaudhuri G, Buaas FW, Braun RE, Hinton DR, Zhang Q,
Grossniklaus HE, Provis JM, Madigan MC, Milam AH, Justice NL, Albuquerque RJ,
Blandford AD, Bogdanovich S, Hirano Y, Witta J, Fuchs E, Littman DR, Ambati BK,
Rudin CM, Chong MM, Provost P, Kugel JF, Goodrich JA, Dunaief JL, Baffi JZ,
Ambati J. DICER1 deficit induces Alu RNA toxicity in age-related macular
degeneration. Nature. 2011 Mar 17;471(7338):325-30. doi: 10.1038/nature09830.
Epub 2011 Feb 6. PMID: 21297615; PMCID: PMC3077055.
104: Iacovelli J, Zhao C, Wolkow N, Veldman P, Gollomp K, Ojha P, Lukinova N,
King A, Feiner L, Esumi N, Zack DJ, Pierce EA, Vollrath D, Dunaief JL.
Generation of Cre transgenic mice with postnatal RPE-specific ocular expression.
Invest Ophthalmol Vis Sci. 2011 Mar 14;52(3):1378-83. doi: 10.1167/iovs.10-6347.
PMID: 21212186; PMCID: PMC3101664.
105: Hadziahmetovic M, Song Y, Wolkow N, Iacovelli J, Grieco S, Lee J, Lyubarsky
A, Pratico D, Connelly J, Spino M, Harris ZL, Dunaief JL. The oral iron chelator
deferiprone protects against iron overload-induced retinal degeneration. Invest
Ophthalmol Vis Sci. 2011 Feb 16;52(2):959-68. doi: 10.1167/iovs.10-6207. PMID:
21051716; PMCID: PMC4183363.
106: Hadziahmetovic M, Song Y, Ponnuru P, Iacovelli J, Hunter A, Haddad N, Beard
J, Connor JR, Vaulont S, Dunaief JL. Age-dependent retinal iron accumulation and
degeneration in hepcidin knockout mice. Invest Ophthalmol Vis Sci. 2011 Jan
5;52(1):109-18. doi: 10.1167/iovs.10-6113. PMID: 20811044; PMCID: PMC3053271.
107: Zhao C, Yasumura D, Li X, Matthes M, Lloyd M, Nielsen G, Ahern K, Snyder M,
Bok D, Dunaief JL, LaVail MM, Vollrath D. mTOR-mediated dedifferentiation of the
retinal pigment epithelium initiates photoreceptor degeneration in mice. J Clin
Invest. 2011 Jan;121(1):369-83. doi: 10.1172/JCI44303. Epub 2010 Dec 6. PMID:
21135502; PMCID: PMC3007156.
108: Xu W, Grunwald JE, Metelitsina TI, DuPont JC, Ying GS, Martin ER, Dunaief
JL, Brucker AJ. Association of risk factors for choroidal neovascularization in
age-related macular degeneration with decreased foveolar choroidal circulation.
Am J Ophthalmol. 2010 Jul;150(1):40-47.e2. doi: 10.1016/j.ajo.2010.01.041. Epub
2010 May 20. PMID: 20493466; PMCID: PMC2900527.
109: Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, Jakobsdottir J,
Tosakulwong N, Pericak-Vance MA, Campochiaro PA, Klein ML, Tan PL, Conley YP,
Kanda A, Kopplin L, Li Y, Augustaitis KJ, Karoukis AJ, Scott WK, Agarwal A,
Kovach JL, Schwartz SG, Postel EA, Brooks M, Baratz KH, Brown WL; Complications
of Age-Related Macular Degeneration Prevention Trial Research Group; Brucker AJ,
Orlin A, Brown G, Ho A, Regillo C, Donoso L, Tian L, Kaderli B, Hadley D,
Hagstrom SA, Peachey NS, Klein R, Klein BE, Gotoh N, Yamashiro K, Ferris Iii F,
Fagerness JA, Reynolds R, Farrer LA, Kim IK, Miller JW, Cortón M, Carracedo A,
Sanchez-Salorio M, Pugh EW, Doheny KF, Brion M, Deangelis MM, Weeks DE, Zack DJ,
Chew EY, Heckenlively JR, Yoshimura N, Iyengar SK, Francis PJ, Katsanis N,
Seddon JM, Haines JL, Gorin MB, Abecasis GR, Swaroop A. Genetic variants near
TIMP3 and high-density lipoprotein-associated loci influence susceptibility to
age-related macular degeneration. Proc Natl Acad Sci U S A. 2010 Apr
20;107(16):7401-6. doi: 10.1073/pnas.0912702107. Epub 2010 Apr 12. PMID:
20385819; PMCID: PMC2867722.
110: Iacovelli J, Mlodnicka AE, Veldman P, Ying GS, Dunaief JL, Schumacher A.
Brain and retinal ferroportin 1 dysregulation in polycythaemia mice. Brain Res.
2009 Sep 15;1289:85-95. doi: 10.1016/j.brainres.2009.06.098. Epub 2009 Jul 9.
PMID: 19596281; PMCID: PMC2736625.
111: Ying GS, Maguire MG, Alexander J, Martin RW, Antoszyk AN; Complications of
Age-related Macular Degeneration Prevention Trial Research Group. Description of
the Age-Related Eye Disease Study 9-step severity scale applied to participants
in the Complications of Age-related Macular Degeneration Prevention Trial. Arch
Ophthalmol. 2009 Sep;127(9):1147-51. doi: 10.1001/archophthalmol.2009.189. PMID:
19752423.
112: Hahn P, Song Y, Ying GS, He X, Beard J, Dunaief JL. Age-dependent and
gender-specific changes in mouse tissue iron by strain. Exp Gerontol. 2009
Sep;44(9):594-600. doi: 10.1016/j.exger.2009.06.006. Epub 2009 Jun 27. PMID:
19563877; PMCID: PMC4552188.
113: Loh A, Hadziahmetovic M, Dunaief JL. Iron homeostasis and eye disease.
Biochim Biophys Acta. 2009 Jul;1790(7):637-49. doi:
10.1016/j.bbagen.2008.11.001. Epub 2008 Nov 14. PMID: 19059309; PMCID:
PMC2718721.
114: Lukinova N, Iacovelli J, Dentchev T, Wolkow N, Hunter A, Amado D, Ying GS,
Sparrow JR, Dunaief JL. Iron chelation protects the retinal pigment epithelial
cell line ARPE-19 against cell death triggered by diverse stimuli. Invest
Ophthalmol Vis Sci. 2009 Mar;50(3):1440-7. doi: 10.1167/iovs.08-2545. Epub 2009
Jan 31. PMID: 19182262; PMCID: PMC2665187.
115: Charkoudian LK, Dentchev T, Lukinova N, Wolkow N, Dunaief JL, Franz KJ.
Iron prochelator BSIH protects retinal pigment epithelial cells against cell
death induced by hydrogen peroxide. J Inorg Biochem. 2008 Dec;102(12):2130-5.
doi: 10.1016/j.jinorgbio.2008.08.001. Epub 2008 Aug 24. PMID: 18835041; PMCID:
PMC2662444.
116: Shoham A, Hadziahmetovic M, Dunaief JL, Mydlarski MB, Schipper HM.
Oxidative stress in diseases of the human cornea. Free Radic Biol Med. 2008 Oct
15;45(8):1047-55. doi: 10.1016/j.freeradbiomed.2008.07.021. Epub 2008 Aug 3.
PMID: 18718524.
117: Clemons TE, Gillies MC, Chew EY, Bird AC, Peto T, Figueroa M, Harrington
MW; Macular Telangiectasia Research Group. The National Eye Institute Visual
Function Questionnaire in the Macular Telangiectasia (MacTel) Project. Invest
Ophthalmol Vis Sci. 2008 Oct;49(10):4340-6. doi: 10.1167/iovs.08-1749. Epub 2008
Jun 27. PMID: 18586874; PMCID: PMC3021355.
118: Complications of Age-related Macular Degeneration Prevention Trial (CAPT)
Research Group. Risk factors for choroidal neovascularization and geographic
atrophy in the complications of age-related macular degeneration prevention
trial. Ophthalmology. 2008 Sep;115(9):1474-9, 1479.e1-6. doi:
10.1016/j.ophtha.2008.03.008. Epub 2008 May 27. PMID: 18502512.
119: Maguire MG, Alexander J, Fine SL; Complications of Age-related Macular
Degeneration Prevention Trial (CAPT) Research Group. Characteristics of
choroidal neovascularization in the complications of age-related macular
degeneration prevention trial. Ophthalmology. 2008 Sep;115(9):1468-73,
1473.e1-2. doi: 10.1016/j.ophtha.2008.02.028. Epub 2008 May 16. PMID: 18486222.
120: Bhisitkul RB, Winn BJ, Lee OT, Wong J, Pereira Dde S, Porco TC, He X, Hahn
P, Dunaief JL. Neuroprotective effect of intravitreal triamcinolone acetonide
against photoreceptor apoptosis in a rabbit model of subretinal hemorrhage.
Invest Ophthalmol Vis Sci. 2008 Sep;49(9):4071-7. doi: 10.1167/iovs.08-1892.
Epub 2008 Apr 17. PMID: 18421081.
121: Hadziahmetovic M, Dentchev T, Song Y, Haddad N, He X, Hahn P, Pratico D,
Wen R, Harris ZL, Lambris JD, Beard J, Dunaief JL. Ceruloplasmin/hephaestin
knockout mice model morphologic and molecular features of AMD. Invest Ophthalmol
Vis Sci. 2008 Jun;49(6):2728-36. doi: 10.1167/iovs.07-1472. Epub 2008 Mar 7.
PMID: 18326691; PMCID: PMC2569891.
122: Metelitsina TI, Grunwald JE, DuPont JC, Ying GS, Brucker AJ, Dunaief JL.
Foveolar choroidal circulation and choroidal neovascularization in age-related
macular degeneration. Invest Ophthalmol Vis Sci. 2008 Jan;49(1):358-63. doi:
10.1167/iovs.07-0526. PMID: 18172113; PMCID: PMC3077130.
123: He X, Hahn P, Iacovelli J, Wong R, King C, Bhisitkul R, Massaro-Giordano M,
Dunaief JL. Iron homeostasis and toxicity in retinal degeneration. Prog Retin
Eye Res. 2007 Nov;26(6):649-73. doi: 10.1016/j.preteyeres.2007.07.004. Epub 2007
Aug 11. PMID: 17921041; PMCID: PMC2093950.
124: Wong RW, Richa DC, Hahn P, Green WR, Dunaief JL. Iron toxicity as a
potential factor in AMD. Retina. 2007 Oct;27(8):997-1003. doi:
10.1097/IAE.0b013e318074c290. PMID: 18040235.
125: Dentchev T, Yao Y, Pratico D, Dunaief J. Isoprostane F2alpha-VI, a new
marker of oxidative stress, increases following light damage to the mouse
retina. Mol Vis. 2007 Feb 7;13:190-5. PMID: 17327824; PMCID: PMC2610371.
126: Hahn P, Ying GS, Beard J, Dunaief JL. Iron levels in human retina: sex
difference and increase with age. Neuroreport. 2006 Nov 27;17(17):1803-6. doi:
10.1097/WNR.0b013e3280107776. PMID: 17164668.
127: Dunaief JL. Iron induced oxidative damage as a potential factor in age-
related macular degeneration: the Cogan Lecture. Invest Ophthalmol Vis Sci. 2006
Nov;47(11):4660-4. doi: 10.1167/iovs.06-0568. PMID: 17065470.
128: Krajacic P, Qian Y, Hahn P, Dentchev T, Lukinova N, Dunaief JL. Retinal
localization and copper-dependent relocalization of the Wilson and Menkes
disease proteins. Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3129-34. doi:
10.1167/iovs.05-1601. PMID: 16799059.
129: Chowers I, Wong R, Dentchev T, Farkas RH, Iacovelli J, Gunatilaka TL,
Medeiros NE, Presley JB, Campochiaro PA, Curcio CA, Dunaief JL, Zack DJ. The
iron carrier transferrin is upregulated in retinas from patients with age-
related macular degeneration. Invest Ophthalmol Vis Sci. 2006 May;47(5):2135-40.
doi: 10.1167/iovs.05-1135. PMID: 16639025.
130: Glazer-Hockstein C, Dunaief JL. Could blue light-blocking lenses decrease
the risk of age-related macular degeneration? Retina. 2006 Jan;26(1):1-4. doi:
10.1097/00006982-200601000-00001. PMID: 16395131.
131: Dentchev T, Hahn P, Dunaief JL. Strong labeling for iron and the iron-
handling proteins ferritin and ferroportin in the photoreceptor layer in age-
related macular degeneration. Arch Ophthalmol. 2005 Dec;123(12):1745-6. doi:
10.1001/archopht.123.12.1745. PMID: 16344450.
132: Hahn P, Lindsten T, Tolentino M, Thompson CB, Bennett J, Dunaief JL.
Persistent fetal ocular vasculature in mice deficient in bax and bak. Arch
Ophthalmol. 2005 Jun;123(6):797-802. doi: 10.1001/archopht.123.6.797. PMID:
15955981.
133: Dunaief JL, Richa C, Franks EP, Schultze RL, Aleman TS, Schenck JF,
Zimmerman EA, Brooks DG. Macular degeneration in a patient with
aceruloplasminemia, a disease associated with retinal iron overload.
Ophthalmology. 2005 Jun;112(6):1062-5. doi: 10.1016/j.ophtha.2004.12.029. PMID:
15882908.
134: Hahn P, Lindsten T, Lyubarsky A, Ying GS, Pugh EN Jr, Thompson CB, Dunaief
JL. Deficiency of Bax and Bak protects photoreceptors from light damage in vivo.
Cell Death Differ. 2004 Nov;11(11):1192-7. doi: 10.1038/sj.cdd.4401486. PMID:
15272317.
135: Rex TS, Tsui I, Hahn P, Maguire AM, Duan D, Bennett J, Dunaief JL.
Adenovirus-mediated delivery of catalase to retinal pigment epithelial cells
protects neighboring photoreceptors from photo-oxidative stress. Hum Gene Ther.
2004 Oct;15(10):960-7. doi: 10.1089/hum.2004.15.960. PMID: 15585111; PMCID:
PMC4118285.
136: Howes KA, Liu Y, Dunaief JL, Milam A, Frederick JM, Marks A, Baehr W.
Receptor for advanced glycation end products and age-related macular
degeneration. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3713-20. doi:
10.1167/iovs.04-0404. PMID: 15452081.
137: Hahn P, Qian Y, Dentchev T, Chen L, Beard J, Harris ZL, Dunaief JL.
Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload
and retinal degeneration with features of age-related macular degeneration. Proc
Natl Acad Sci U S A. 2004 Sep 21;101(38):13850-5. doi: 10.1073/pnas.0405146101.
Epub 2004 Sep 13. PMID: 15365174; PMCID: PMC518844.
138: Hahn P, Dentchev T, Qian Y, Rouault T, Harris ZL, Dunaief JL.
Immunolocalization and regulation of iron handling proteins ferritin and
ferroportin in the retina. Mol Vis. 2004 Aug 26;10:598-607. PMID: 15354085.
139: Chen L, Wu W, Dentchev T, Wong R, Dunaief JL. Increased metallothionein in
light damaged mouse retinas. Exp Eye Res. 2004 Aug;79(2):287-93. doi:
10.1016/j.exer.2004.05.004. PMID: 15325575.
140: Chen L, Wu W, Dentchev T, Zeng Y, Wang J, Tsui I, Tobias JW, Bennett J,
Baldwin D, Dunaief JL. Light damage induced changes in mouse retinal gene
expression. Exp Eye Res. 2004 Aug;79(2):239-47. doi: 10.1016/j.exer.2004.05.002.
PMID: 15325571.
141: King A, Gottlieb E, Brooks DG, Murphy MP, Dunaief JL. Mitochondria-derived
reactive oxygen species mediate blue light-induced death of retinal pigment
epithelial cells. Photochem Photobiol. 2004 May;79(5):470-5. doi:
10.1562/le-03-17.1. PMID: 15191057.
142: Hahn P, Milam AH, Dunaief JL. Maculas affected by age-related macular
degeneration contain increased chelatable iron in the retinal pigment epithelium
and Bruch's membrane. Arch Ophthalmol. 2003 Aug;121(8):1099-105. doi:
10.1001/archopht.121.8.1099. PMID: 12912686.
143: Hahn P, Lindsten T, Ying GS, Bennett J, Milam AH, Thompson CB, Dunaief JL.
Proapoptotic bcl-2 family members, Bax and Bak, are essential for developmental
photoreceptor apoptosis. Invest Ophthalmol Vis Sci. 2003 Aug;44(8):3598-605.
doi: 10.1167/iovs.02-1113. PMID: 12882813.
144: Dentchev T, Milam AH, Lee VM, Trojanowski JQ, Dunaief JL. Amyloid-beta is
found in drusen from some age-related macular degeneration retinas, but not in
drusen from normal retinas. Mol Vis. 2003 May 14;9:184-90. PMID: 12764254.
145: Chen L, Dentchev T, Wong R, Hahn P, Wen R, Bennett J, Dunaief JL. Increased
expression of ceruloplasmin in the retina following photic injury. Mol Vis. 2003
Apr 30;9:151-8. PMID: 12724641.
146: Dunaief JL, Dentchev T, Ying GS, Milam AH. The role of apoptosis in age-
related macular degeneration. Arch Ophthalmol. 2002 Nov;120(11):1435-42. doi:
10.1001/archopht.120.11.1435. PMID: 12427055.
147: Dunaief JL, King A, Esumi N, Eagen M, Dentchev T, Sung CH, Chen S, Zack DJ.
Protein Phosphatase 1 binds strongly to the retinoblastoma protein but not to
p107 or p130 in vitro and in vivo. Curr Eye Res. 2002 May;24(5):392-6. doi:
10.1076/ceyr.24.5.392.8524. PMID: 12434308.
148: Dunaief JL, Conway J, Rigamonti D, Goldberg MF. Retinal venous
telangiectasia and anastomoses with cerebellar venous and cavernous
malformation. Retina. 2001;21(3):262-5. doi: 10.1097/00006982-200106000-00013.
PMID: 11421019.
149: Dunaief JL, Ng EW, Goldberg MF. Corneal dystrophies of epithelial genesis:
the possible therapeutic use of limbal stem cell transplantation. Arch
Ophthalmol. 2001 Jan;119(1):120-2. PMID: 11146737.
150: Strober BE, Dunaief JL, Guha, Goff SP. Functional interactions between the
hBRM/hBRG1 transcriptional activators and the pRB family of proteins. Mol Cell
Biol. 1996 Apr;16(4):1576-83. doi: 10.1128/MCB.16.4.1576. PMID: 8657132; PMCID:
PMC231143.
151: Dunaief JL, Kwun RC, Bhardwaj N, Lopez R, Gouras P, Goff SP. Retroviral
gene transfer into retinal pigment epithelial cells followed by transplantation
into rat retina. Hum Gene Ther. 1995 Sep;6(9):1225-9. doi:
10.1089/hum.1995.6.9-1225. PMID: 8527481.
152: Dunaief JL, Strober BE, Guha S, Khavari PA, Alin K, Luban J, Begemann M,
Crabtree GR, Goff SP. The retinoblastoma protein and BRG1 form a complex and
cooperate to induce cell cycle arrest. Cell. 1994 Oct 7;79(1):119-30. doi:
10.1016/0092-8674(94)90405-7. PMID: 7923370.