Home

Our laboratory has two areas of interest – eicosanoid biology and molecular clocks.

In the case of eicosanoids, we are interested in the role they play in modulating the immune response in atherosclerosis and cancer, the promotion and restraint of cardiopulmonary fibrosis, in the response to viral infection and in stem cell biology. We are interested in the many factors that contribute to variability in the response to NSAIDs, including the microbiome, genomics, time of drug administration and metabolomics; the use of dynamic and network-based modelling to study drug response and the use of AI and machine learning approaches to develop paradigms predictive of efficacy and risk.

In the case of clocks, we are interested in how a decline in oscillatory function may contribute to age related phenotypes. We are integrating multiple remote sensing approaches with multi-omics analyses to characterize the human chronobiome and to identify time dependent networks that decline with age. Besides affording insight into the trajectory of aging this may afford the opportunity to obtain, in an unbiased fashion, mechanistic insights into time dependent disease phenotypes, such as non-dipping hypertension.

Publications

• Novel Mouse Model of Coronary Atherosclerosis With Myocardial Infarction: Insights Into Human CAD.
  Circulation research. 2025 Jun 9; Authors: Chen H, Wan Q, Yang J, Rao H, Xu C, Xu P, Yang X, Wang H, Feng W, Wang L, Bäck M, Widdop RE, Liu F, Lu HS, Daugherty A, Hu S, FitzGerald GA, Liu DP, Huang Y, Jin W, Wang M

• Prostaglandins and the Cardiovascular System.
  Arteriosclerosis, thrombosis, and vascular biology. 2025 Jun;45(6):841-844 Epub 2025 May 21; Authors: Ricciotti E, FitzGerald GA

• Arachidonic acid synergizes with aspirin preventing myocardial ischaemia-reperfusion injury and mitigates bleeding risk.
  Cardiovascular research. 2025 May 23;121(5):775-787; Authors: Talabieke S, Yang X, Yang J, Wan Q, Zhu D, Rao H, Wu Y, Chen Z, Li H, Xu P, Chen H, Liu DP, Zhang X, FitzGerald GA, Wang M

• Technical recommendations for analyzing oxylipins by liquid chromatography-mass spectrometry.
  Science signaling. 2025 May 20;18(887):eadw1245; Authors: Schebb NH, Kampschulte N, Hagn G, Plitzko K, Meckelmann SW, Ghosh S, Joshi R, Kuligowski J, Vuckovic D, Botana MT, Sánchez-Illana Á, Zandkarimi F, Das A, Yang J, Schmidt L, Checa A, Roche HM, Armando AM, Edin ML, Lih FB, Aristizabal-Henao JJ, Miyamoto S, Giuffrida F, Moussaieff A, Domingues R, Rothe M, Hinz C, Das US, Rund KM, Taha AY, Hofstetter RK, Werner M, Werz O, Kahnt AS, Bertrand-Michel J, Le Faouder P, Gurke R, Thomas D, Torta F, Milic I, Dias IHK, Spickett CM, Biagini D, Lomonaco T, Idborg H, Liu JY, Fedorova M, Ford DA, Barden A, Mori TA, Kennedy PD, Maxey K, Ivanisevic J, Gallart-Ayala H, Gladine C, Wenk M, Galano JM, Durand T, Stark KD, Barbas C, Garscha U, Gelhaus SL, Ceglarek U, Flamand N, Griffin JL, Ahrends R, Arita M, Zeldin DC, Schopfer FJ, Quehenberger O, Julian R, Nicolaou A, Blair IA, Murphy MP, Hammock BD, Freeman B, Liebisch G, Serhan CN, Köfeler HC, Jakobsson PJ, Steinhilber D, Gelb MH, Holčapek M, Andrew R, Giera M, FitzGerald GA, Murphy RC, Newman JW, Dennis EA, Ekroos K, Milne GL, Gijón MA, Vesper HW, Wheelock CE, O'Donnell VB

• Obliquity disruption and Antarctic ice sheet dynamics over a 2.4-Myr astronomical grand cycle.
  Science advances. 2025 Apr 25;11(17):eadl1996; Authors: Sullivan NB, Meyers SR, Levy RH, McKay RM, van de Flierdt T, Marschalek J, Perotti M, Zurli L, Talarico F, Harwood D, De Santis L, Florindo F, Naish TR, Grant GR, Patterson MO, Expedition 374 scientists