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Our laboratory has two areas of interest – eicosanoid biology and molecular clocks.
In the case of eicosanoids, we are interested in the role they play in modulating the immune response in atherosclerosis and cancer, the promotion and restraint of cardiopulmonary fibrosis, in the response to viral infection and in stem cell biology. We are interested in the many factors that contribute to variability in the response to NSAIDs, including the microbiome, genomics, time of drug administration and metabolomics; the use of dynamic and network-based modelling to study drug response and the use of AI and machine learning approaches to develop paradigms predictive of efficacy and risk.
In the case of clocks, we are interested in how a decline in oscillatory function may contribute to age related phenotypes. We are integrating multiple remote sensing approaches with multi-omics analyses to characterize the human chronobiome and to identify time dependent networks that decline with age. Besides affording insight into the trajectory of aging this may afford the opportunity to obtain, in an unbiased fashion, mechanistic insights into time dependent disease phenotypes, such as non-dipping hypertension.
Publications
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Challenges and best practices in omics benchmarking.
Nature reviews. Genetics. 2024 May;25(5):326-339 Epub 2024 Jan 12; Authors: Brooks TG, Lahens NF, Mrčela A, Grant GR -
Differential Impact In Vivo of Pf4-ΔCre-Mediated and Gp1ba-ΔCre-Mediated Depletion of Cyclooxygenase-1 in Platelets in Mice.
Arteriosclerosis, thrombosis, and vascular biology. 2024 Apr 25; Authors: Tang SY, Lordan R, Meng H, Auerbach BJ, Hennessy EJ, Sengupta A, Das US, Joshi R, Marcos-Contreras OA, McConnell R, Grant GR, Ricciotti E, Muzykantov VR, Grosser T, Weiljie AM, FitzGerald GA -
BEERS2: RNA-Seq simulation through high fidelity in silico modeling.
Briefings in bioinformatics. 2024 Mar 27;25(3); Authors: Brooks TG, Lahens NF, Mrčela A, Sarantopoulou D, Nayak S, Naik A, Sengupta S, Choi PS, Grant GR -
Circadian regulation of lung repair and regeneration.
JCI insight. 2024 Mar 8;9(5); Authors: Naik A, Forrest KM, Paul O, Issah Y, Valekunja UK, Tang SY, Reddy AB, Hennessy EJ, Brooks TG, Chaudhry F, Babu A, Morley M, Zepp JA, Grant GR, FitzGerald GA, Sehgal A, Worthen GS, Frank DB, Morrisey EE, Sengupta S -
Prostanoids in Cardiac and Vascular Remodeling.
Arteriosclerosis, thrombosis, and vascular biology. 2024 Mar;44(3):558-583 Epub 2024 Jan 25; Authors: Ricciotti E, Haines PG, Chai W, FitzGerald GA