Publications

• Segregate Assessment of Data Validity from the More Complex Issue of Fraud.
  The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics. 2025 Mar 21;:1-3; Authors: FitzGerald GA

• Sleep disorders as risk factors for calcific aortic stenosis.
  American journal of preventive cardiology. 2025 Jun;22:100958 Epub 2025 Mar 9; Authors: El Jamal N, Brooks TG, Skarke C, FitzGerald GA

• Generating Correlated Data for Omics Simulation.
  bioRxiv : the preprint server for biology. 2025 Feb 6; Authors: Yang J, Grant GR, Brooks TG

• Sources of non-uniform coverage in short-read RNA-Seq data.
  bioRxiv : the preprint server for biology. 2025 Feb 6; Authors: Brooks TG, Lahens NF, Mrčela A, Yang J, Purohit S, Naik A, Ricciotti E, Sengupta S, Choi PS, Grant GR

• MAJIQ-CLIN: A novel tool for the identification of Mendelian disease-causing variants from RNA-Seq data.
  medRxiv : the preprint server for health sciences. 2025 Feb 2; Authors: Aicher JK, Issakova D, Slaff B, Jewell S, Lahens NF, Grant GR, Baralle D, Rosenfeld JA, Scott DA, Undiagnosed Diseases Network, Bhoj EJ, Barash Y

• Critically ill patients with a reverse blood pressure dipping phenotype at increased risk for delirium and death.
  medRxiv : the preprint server for health sciences. 2025 Jan 30; Authors: El Jamal N, Brooks TG, Mrcela A, Genuardi MV, FitzGerald GA, Skarke C

• Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes.
  Cell. 2025 Jan 9;188(1):187-206.e26 Epub 2024 Nov 11; Authors: Guo JL, Braun D, Fitzgerald GA, Hsieh YT, Rougé L, Litvinchuk A, Steffek M, Propson NE, Heffner CM, Discenza C, Han SJ, Rana A, Skuja LL, Lin BQ, Sun EW, Davis SS, Balasundar S, Becerra I, Dugas JC, Ha C, Hsiao-Nakamoto J, Huang F, Jain S, Kung JE, Liau NPD, Mahon CS, Nguyen HN, Nguyen N, Samaddar M, Shi Y, Tatarakis D, Tian Y, Zhu Y, Suh JH, Sandmann T, Calvert MEK, Arguello A, Kane LA, Lewcock JW, Holtzman DM, Koth CM, Di Paolo G

• Arachidonic acid synergizes with aspirin preventing myocardial ischemia-reperfusion injury and mitigates bleeding risk.
  Cardiovascular research. 2025 Jan 9; Authors: Talabieke S, Yang X, Yang J, Wan Q, Zhu D, Rao H, Wu Y, Chen Z, Li H, Xu P, Chen H, Liu DP, Zhang X, FitzGerald GA, Wang M

• Concomitant suppression of COX-1 and COX-2 is insufficient to induce enteropathy associated with chronic NSAID use.
  bioRxiv : the preprint server for biology. 2025 Jan 8; Authors: Barekat K, Ricciotti E, Ghosh S, Herrmann C, Keat K, Assenmacher CA, Tanes C, Wilson N, Sengupta A, Das US, Joshi R, Ritchie MD, Bittinger K, Weljie A, Cadwell K, Bushman FD, Wu GD, FitzGerald GA

• Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome.
  Cell metabolism. 2025 Jan 7;37(1):154-168.e7 Epub 2024 Nov 18; Authors: Li S, Liu H, Hu H, Ha E, Prasad P, Jenkins BC, Das US, Mukherjee S, Shishikura K, Hu R, Rader DJ, Pei L, Baur JA, Matthews ML, FitzGerald GA, McReynolds MR, Susztak K

• Chiral clues to lipid identity.
  Journal of lipid research. 2025 Jan;66(1):100710 Epub 2024 Nov 20; Authors: Das US, FitzGerald GA

• Metabolomic Response to Non-Steroidal Anti-Inflammatory Drugs.
  bioRxiv : the preprint server for biology. 2024 Dec 2; Authors: Ghosh S, Lahens N, Barekat K, Tang SY, Theken KN, Ricciotti E, Sengupta A, Joshi R, Bushman FD, Weljie A, Grosser T, FitzGerald GA

• Suppression of cyclooxygenase-2 predisposes to heart failure with preserved ejection fraction.
  bioRxiv : the preprint server for biology. 2024 Nov 26; Authors: Ricciotti E, Haines PG, Beerens M, Kartoun U, Castro C, Tang SY, Ghosh S, Das US, Lahens NF, Wang T, Griffin JL, Shaw SY, MacRae CA, FitzGerald GA

• Pivotal roles for cancer cell-intrinsic mPGES-1 and autocrine EP4 signaling in suppressing antitumor immunity.
  JCI insight. 2024 Nov 8;9(21); Authors: Markosyan N, Kim IK, Arora C, Quinones-Ware L, Joshi N, Cheng N, Schechter EY, Tobias JW, Hochberg JE, Corse E, Liu K, Rodriguez DiBlasi V, Chan LE, Smyth EM, FitzGerald GA, Stanger BZ, Vonderheide RH

• Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms.
  eLife. 2024 Nov 1;12; Authors: Schwarz JE, Mrčela A, Lahens NF, Li Y, Hsu C, Grant GR, Skarke C, Zhang SL, Sehgal A

• Brown adipose tissue thermogenesis rhythms are driven by the SCN independent of adipocyte clocks.
  bioRxiv : the preprint server for biology. 2024 Oct 28; Authors: Paschos GK, Lordan R, Hollingsworth T, Lekkas D, Kelch S, Loro E, Verginadis I, Khurana T, Sengupta A, Weljie A, FitzGerald GA

• Disruption of the PGE(2) synthesis / response pathway restrains atherogenesis in programmed cell death-1 (Pd-1) deficient hyperlipidemic mice.
  bioRxiv : the preprint server for biology. 2024 Sep 15; Authors: Ricciotti E, Tang SY, Mrčela A, Das US, Lordan R, Joshi R, Ghosh S, Aoyama J, McConnell R, Yang J, Grant GR, FitzGerald GA

• Differential Impact In Vivo of Pf4-ΔCre-Mediated and Gp1ba-ΔCre-Mediated Depletion of Cyclooxygenase-1 in Platelets in Mice.
  Arteriosclerosis, thrombosis, and vascular biology. 2024 Jun;44(6):1393-1406 Epub 2024 Apr 25; Authors: Tang SY, Lordan R, Meng H, Auerbach BJ, Hennessy EJ, Sengupta A, Das US, Joshi R, Marcos-Contreras OA, McConnell R, Grant GR, Ricciotti E, Muzykantov VR, Grosser T, Weiljie AM, FitzGerald GA

• Degree of Cyclooxygenase-2 Inhibition Modulates Blood Pressure Response to Celecoxib and Naproxen.
  medRxiv : the preprint server for health sciences. 2024 May 31; Authors: Theken KN, Ghosh S, Skarke C, Fries S, Lahens NF, Sarantopoulou D, Grant GR, FitzGerald GA, Grosser T

• Prognostic utility of rhythmic components in 24-h ambulatory blood pressure monitoring for the risk stratification of chronic kidney disease patients with cardiovascular co-morbidity.
  Journal of human hypertension. 2024 May;38(5):420-429 Epub 2024 Jan 11; Authors: El Jamal N, Brooks TG, Cohen J, Townsend RR, Sosa GR, Shah V, Chronic Renal Insufficiency Cohort Study (CRIC) Consortium, Nelson RG, Drawz PE, Rao P, Bhat Z, Chang A, Yang W, FitzGerald GA, Skarke C

• Challenges and best practices in omics benchmarking.
  Nature reviews. Genetics. 2024 May;25(5):326-339 Epub 2024 Jan 12; Authors: Brooks TG, Lahens NF, Mrčela A, Grant GR

• BEERS2: RNA-Seq simulation through high fidelity in silico modeling.
  Briefings in bioinformatics. 2024 Mar 27;25(3); Authors: Brooks TG, Lahens NF, Mrčela A, Sarantopoulou D, Nayak S, Naik A, Sengupta S, Choi PS, Grant GR

• Circadian regulation of lung repair and regeneration.
  JCI insight. 2024 Mar 8;9(5); Authors: Naik A, Forrest KM, Paul O, Issah Y, Valekunja UK, Tang SY, Reddy AB, Hennessy EJ, Brooks TG, Chaudhry F, Babu A, Morley M, Zepp JA, Grant GR, FitzGerald GA, Sehgal A, Worthen GS, Frank DB, Morrisey EE, Sengupta S

• Prostanoids in Cardiac and Vascular Remodeling.
  Arteriosclerosis, thrombosis, and vascular biology. 2024 Mar;44(3):558-583 Epub 2024 Jan 25; Authors: Ricciotti E, Haines PG, Chai W, FitzGerald GA

• Designer high-density lipoprotein particles enhance endothelial barrier function and suppress inflammation.
  Science signaling. 2024 Feb 20;17(824):eadg9256; Authors: Lin YC, Swendeman S, Moreira IS, Ghosh A, Kuo A, Rosário-Ferreira N, Guo S, Culbertson A, Levesque MV, Cartier A, Seno T, Schmaier A, Galvani S, Inoue A, Parikh SM, FitzGerald GA, Zurakowski D, Liao M, Flaumenhaft R, Gümüş ZH, Hla T

• COX Postulates: Remember the Fibroblast.
  Arteriosclerosis, thrombosis, and vascular biology. 2024 Jan;44(1):287-289 Epub 2023 Nov 16; Authors: FitzGerald GA

• PGF2α signaling drives fibrotic remodeling and fibroblast population dynamics in mice.
  JCI insight. 2023 Dec 22;8(24); Authors: Rodriguez LR, Tang SY, Roque Barboza W, Murthy A, Tomer Y, Cai TQ, Iyer S, Chavez K, Das US, Ghosh S, Cooper CH, Dimopoulos TT, Babu A, Connelly C, FitzGerald GA, Beers MF

• Endothelial lipid droplets suppress eNOS to link high fat consumption to blood pressure elevation.
  The Journal of clinical investigation. 2023 Dec 15;133(24); Authors: Kim B, Zhao W, Tang SY, Levin MG, Ibrahim A, Yang Y, Roberts E, Lai L, Li J, Assoian RK, FitzGerald GA, Arany Z

• Meta-analysis of Diurnal Transcriptomics in Mouse Liver Reveals Low Repeatability of Rhythm Analyses.
  Journal of biological rhythms. 2023 Dec;38(6):556-570 Epub 2023 Jun 29; Authors: Brooks TG, Manjrekar A, Mrcˇela A, Grant GR

• Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples.
  Nature communications. 2023 Nov 9;14(1):7172; Authors: O'Donnell VB, Schebb NH, Milne GL, Murphy MP, Thomas CP, Steinhilber D, Gelhaus SL, Kühn H, Gelb MH, Jakobsson PJ, Blair IA, Murphy RC, Freeman BA, Brash AR, FitzGerald GA