Innovation

Research in the Department spans a broad spectrum of cutting-edge genetics, encompassing global genomics, evolution of complex traits, single-cell multiomics, precision gene editing, and mechanisms of epigenetic inheritance, among others.

Passion

Our faculty, trainees, and staff are united by an enduring curiosity about the fundamental principles of life and a relentless drive to uncover the genetic underpinnings of health and disease.

Collaboration

Scientific discovery in the Department is deeply collaborative by design. Faculty partner across disciplines with leading experts in medicine, computational biology, engineering, and public health to tackle the most complex questions in genetics.

Impact

Our labs combine advanced technologies with biological insights to accelerate the translation of genetic knowledge in precision medicine, enhance genomic diagnostics, and train future leaders in genomic science.

Message from the Chair: Daniel J. Rader, M.D.

Welcome to the Department of Genetics at the Perelman School of Medicine (PSOM) at the University of Pennsylvania. Our 35 primary faculty members conduct cutting-edge research across a broad spectrum of genetics and genomics, including human genetics, evolutionary and population genetics, epigenetics, functional genomics, experimental model systems, RNA biology, and computational and statistical genomics. Our research ranges from fundamental biological discovery to genomic medicine and translational therapeutics. As the central hub for genetics and genomics research on campus, the Department maintains strong collaborations with clinical departments and numerous Centers and Institutes across PSOM and the University. We also provide administrative oversight for several core facilities that support research laboratories throughout the School of Medicine and affiliated institutions. Additionally, the Department plays a vital role in educating medical and graduate students, as well as training the next generation of genomic scientists.

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News

Department of Genetics Reflects, Connects, and Plans for the Future

The Department of Genetics gathered for its Fall Retreat, bringing together faculty, staff, and trainees to reflect on recent accomplishments, share ideas, and strengthen collaborations. The event provided an opportunity to celebrate the department’s achievements while looking ahead to future research, education, and community-building initiatives.

2026 Kaushal Family Award in Genetics

The Department of Genetics congratulates Fabián Ramos-Almodóvar, Bumsik Cho, and Zachary Rosenthal, recipients of the 2026 Kaushal Family Awards. The Kaushal Awards recognize outstanding predoctoral and postdoctoral scholars for excellence in genetic research, as demonstrated through significant publication.

The awardees presentd their research during a special Genetics Friday Research in Progress session on October 30, 2026. 

Philadelphia Long-read Sequencing Workshop

Come join us and learn how to leverage long-read sequencing technologies to study the transcriptome!

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Featured Publications

CRISPR-associated enzymes are mislocalized to the cytoplasm in iPSC-derived neurons, resulting in KRAB(KOX1)-specific degradation

Shalem Lab

Anthropometric and cardio-metabolic trait variation and genetic associations in sub-Saharan Africa.

Tishkoff Lab

A global view of human centromere variation and evolution

Logsdon Lab

Large-scale admixture mapping in the All of Us Research Program improves the characterization of cross-population phenotypic differences

Pasaniuc Lab

Single-allele chromatin tracing reveals cytokine-dependent super-enhancer repositioning in CD4+ T cells

Vahedi Lab

Biallelic inactivating variants in the chromatin remodeler DMAP1 cause a syndromic neurodevelopmental disorder

Dong Li, PhD

Cross-species variant-to-function analyses implicate MEIS1 in conferring sleep abnormalities and impaired cerebellar development

Grant Lab

Genome-wide analysis implicates inner ear development in Ménière disease

Pasaniuc, Epstein, and Mathieson Labs

Go to the Publications Page