Elizabeth A Grice, PhD
The Sandra J. Lazarus Professor in Dermatology

- Member, Institute for Immunology
- Member, Institute for Regenerative Medicine
- Member, Institute for Diabetes, Obesity, and Metabolism
- Associate Director, Penn SBDRC Data Sciences and Informatics (DSI) Core
- Director, Penn Skin Biology and Diseases Resource-based Center (SBDRC)
- Vice Chair of Basic Research, Department of Dermatology, Perelman School of Medicine
Department: Dermatology
Graduate Group Affiliations
Contact Information
421 Curie Blvd
1015 BRB II/III
Philadelphia, PA 19104
Office: 215-898-3179
Lab Phone: 215-573-1095
I3H Keywords
- Allergy, Asthma, and Other Inflammatory Diseases
- Innate and Adaptive Immunity to Pathogens
Publications
Links
Education
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B.A. (Biology)
Luther College, 2001 -
Ph.D. (Human Genetics)
Johns Hopkins University, 2006
Post-Graduate Training
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Post-doctoral Fellowship
National Human Genome Research Institute, National Institutes of Health, 2007 - 2011
Description of Research Expertise
Research Interests:
Skin microbiome; cutaneous host-microbe interactions; wound healing
Research Description:
The skin is a formidable barrier and the first line of defense against the external environment. The skin is also colonized with microbial communities, which we hypothesize have critical functions in cutaneous health and disease. These functions may include but are not limited to colonization resistance to block invasion by opportunistic or pathogenic microbiota and regulation of immunity and inflammation. Various cutaneous disorders and infections are hypothesized to in part result from dysregulation of microbiota-host interactions. The Grice lab applies a variety of different approaches, model systems, and human tissues and isolates to elucidate mechanisms regulating such interactions.
Currently, research in the laboratory is divided into the following focus areas:
(1) Skin microbiome regulation of epithelial defense
(2) Microbial regulation of tissue repair and inflammation in chronic wounds
(3) Skin microbiota-driven mechanisms of colonization resistance to pathogens
Selected Publications
- Barbieri JS, Ellenberg S, Grice E, Tierney A, VanderBeek SB, Papadopoulos M, Mason J, Mason A, Dattilo J, Margolis DJ. : Challenges in designing a randomized, double-blind noninferiority trial for treatment of acne: The SD-ACNE trial Clin Trials Jul 2024
- White EK, Uberoi A, Pan JT, Ort JT, Campbell AE, Murga-Garrido SM, Harris JC, Bhanap P, Wei M, Robles NY, Gardner SE, Grice EA. : Alcaligenes faecalis corrects aberrant matrix metalloproteinase expression to promote reepithelialization of diabetic wounds Sci Adv 10 : eadj2020, Jun 2024
- Campbell A, Bae J, Hein M, Hillis SL, Rebeck ON, Rakel BA, Grice E, Gardner SE. : The heterogeneous wound microbiome varies with wound care pain, dressing type, and inflammatory gene expression Wound Repair Regen Apr 2024
- Harris JC, Trigg NA, Goshu B, Yokoyama Y, Dohnalová L, White EK, Harman A, Murga-Garrido SM, Ting-Chun Pan J, Bhanap P, Thaiss CA, Grice EA, Conine CC, Kambayashi T. : The microbiota and T cells non-genetically modulate inherited phenotypes transgenerationally Cell Rep 43 : 114029, Apr 2024
- Cain CL, White E, Citron LE, Zheng Q, Morris DO, Grice EA, Bradley CW 2nd. : Longitudinal evaluation of the cutaneous and rectal microbiota of German shepherd dogs with perianal fistulas undergoing therapy with ciclosporin and ketoconazole Vet Dermatol Apr 2024
- Wei M, Knight SA, Fazelinia H, Spruce L, Roof J, Chu E, Walsh J, Flowers L, Kim DY, Zhu J, Grice EA. : An exploration of mechanisms underlying Desemzia incerta colonization resistance to methicillin-resistant Staphylococcus aureus on the skin mSphere 9 : e0063623, March 2024
- Singh TP, Farias Amorim C, Lovins VM, Bradley CW, Carvalho LP, Carvalho EM, Grice EA, Scott P. : Regulatory T cells control Staphylococcus aureus and disease severity of cutaneous leishmaniasis J Exp Med 220 : e20230558, Dec 2023
- Harris JC, Prouty SM, Nelson MA, Sung DC, Nelson AM, Seykora JT, Kambayashi T, Grice EA. : Laser Capture Microdissection-based RNAseq for Profiling Mouse and Human Sebaceous Gland Transcriptomes J Invest Dermatol Nov 2023
- Wei M, Knight SAB, Flowers L, Walsh J, Grice E. : Complete genome sequence of the bacterium Desemzia incerta isolated from the dorsal skin of a Yucatan pig Microbiol Resour Announc 12 : e0051923, Nov 2023
- Hajfathalian M, de Vries CR, Hsu JC, Amirshaghaghi A, Dong YC, Ren Z, Liu Y, Huang Y, Li Y, Knight SA, Jonnalagadda P, Zlitni A, Grice EA, Bollyky PL, Koo H, Cormode DP. : Theranostic gold-in-gold cage nanoparticles enable photothermal ablation and photoacoustic imaging in biofilm-associated infection models J Clin Invest 133 : e168485, Nov 2023