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Key Publications

A Multivalent mRNA-LNP Vaccine Protects Against Clostridioides Difficile Infection

Alameh MG, Semon A, Bayard NU, Pan YG, Dwivedi G, Knox J, Glover RC, Rangel PC, Tanes C, Bittinger K, She Q, Hu H, Bonam SR, Maslanka JR, Planet PJ, Moustafa AM, Davis B, Chevrier A, Beattie M, Ni H,...

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Improved Influenza Vaccine Responses After Expression of Multiple Viral Glycoproteins From a Single mRNA

Leonard RA, Burke KN, Spreng RL, Macintyre AN, Tam Y, Alameh MG, Weissman D, Heaton NS.

Nat Commun. 2024 Oct 8;15(1):8712. PMID: 39379405 

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Circulating KRAS G12D But Not G12V is Associated With Survival in Metastatic Pancreatic Ductal Adenocarcinoma

Till JE, McDaniel L, Chang C, Long Q, Pfeiffer SM, Lyman JP, Padrón LJ, Maurer DM, Yu JX, Spencer CN, Gherardini PF, Da Silva DM, LaVallee TM, Abbott C, Chen RO, Boyle SM, Bhagwat N, Cannas S, Sagreiya H, Li...

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An Iron-Rich Subset of Macrophages Promotes Tumor Growth Through a Bach1-Ednrb Axis

Folkert IW, Molina Arocho WA, To TKJ, Devalaraja S, Molina IS, Shoush J, Mohei H, Zhai L, Akhtar MN, Kochat V, Arslan E, Lazar AJ, Wani K, Israel WP, Zhang Z, Chaluvadi VS, Norgard RJ, Liu Y, Fuller AM, Dang...

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Senescent Cancer-Associated Fibroblasts in Pancreatic Adenocarcinoma Restrict CD8+ T Cell Activation and Limit Responsiveness to Immunotherapy in Mice

Assouline B, Kahn R, Hodali L, Condiotti R, Engel Y, Elyada E, Mordechai-Heyn T, Pitarresi JR, Atias D, Steinberg E, Bidany-Mizrahi T, Forkosh E, Katz LH, Benny O, Golan T, Hofree M, Stewart SA, Atlan KA, Zamir G, Stanger BZ...

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Transdifferentiation Occurs Without Resetting Development-Specific DNA Methylation, a Key Determinant of Full-Function Cell Identity

Radwan A, Eccleston J, Sabag O, Marcus H, Sussman J, Ouro A, Rahamim M, Azagury M, Azria B, Stanger BZ, Cedar H, Buganim Y.

Proc Natl Acad Sci U S A. 2024 Sep 24;121(39):e2411352121. Epub 2024 Sep 18. PMID: 39292740

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Two Clinical Trials Assessing Treatments for Eosinophilic Esophagitis

Chehade M, Dellon ES, Spergel JM.

N Engl J Med. 2024 Sep 19;391(11):1066-1067. PMID: 39292938 

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Modified C-Type Natriuretic Peptide Normalizes Tumor Vasculature, Reinvigorates Antitumor Immunity, and Improves Solid Tumor Therapies

Lu Z, Verginadis I, Kumazoe M, Castillo GM, Yao Y, Guerra RE, Bicher S, You M, McClung G, Qiu R, Xiao Z, Miao Z, George SS, Beiting DP, Nojiri T, Tanaka Y, Fujimura Y, Onda H, Hatakeyama Y, Nishimoto-Ashfield...

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Immunologic Signatures of Response and Resistance to Nivolumab With Ipilimumab in Advanced Metastatic Cancer

Tsimberidou AM, Alayli FA, Okrah K, Drakaki A, Khalil DN, Kummar S, Khan SA, Hodi FS, Oh DY, Cabanski CR, Gautam S, Meier SL, Amouzgar M, Pfeiffer SM, Kageyama R, Yang E, Spasic M, Tetzlaff MT, Foo WC, Hollmann TJ,...

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Proton Radiation Boosts the Efficacy of Mesothelin-Targeting Chimeric Antigen Receptor T Cell Therapy in Pancreatic Cancer

Amit U, Uslu U, Verginadis II, Kim MM, Motlagh SAO, Diffenderfer ES, Assenmacher CA, Bicher S, Atoche SJ, Ben-Josef E, Young RM, June CH, Koumenis C.

Proc Natl Acad Sci U S A. 2024 Jul 30;121(31):e2403002121.Epub 2024 Jul 24. PMID: 39047033 

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CAR T Cell Combination Therapies to Treat Cancer

Uslu U, Castelli S, June CH.

Cancer Cell. 2024 Aug 12;42(8):1319-1325. Epub 2024 Jul 25. PMID: 39059390 

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Intestinal cDC1s Provide Cues Required for CD4+ T Cell-Mediated Resistance to Cryptosporidium

Cohn IS, Wallbank BA, Haskins BE, O'Dea KM, Pardy RD, Shaw S, Merolle MI, Gullicksrud JA, Christian DA, Striepen B, Hunter CA.

J Exp Med. 2024 Jul 1;221(7):e20232067. Epub 2024 Jun 3. PMID: 38829369

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Clonal Hematopoiesis Driven by Mutated DNMT3A Promotes Inflammatory Bone Loss

Wang H, Divaris K, Pan B, Li X, Lim JH, Saha G, Barovic M, Giannakou D, Korostoff JM, Bing Y, Sen S, Moss K, Wu D, Beck JD, Ballantyne CM, Natarajan P, North KE, Netea MG, Chavakis T, Hajishengallis G....

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Use of 3M-052-AF With Alum Adjuvant in HIV Trimer Vaccine Induces Human Autologous Neutralizing Antibodies

Hahn WO, Parks KR, Shen M, Ozorowski G, Janes H, Ballweber-Fleming L, Woodward Davis AS, Duplessis C, Tomai M, Dey AK, Sagawa ZK, De Rosa SC, Seese A, Kallur Siddaramaiah L, Stamatatos L, Lee WH, Sewall LM, Karlinsey D, Turner...

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Genetic and Environmental Interactions Contribute to Immune Variation in Rewilded Mice

Oyesola O, Downie AE, Howard N, Barre RS, Kiwanuka K, Zaldana K, Chen YH, Menezes A, Lee SC, Devlin J, Mondragón-Palomino O, Souza COS, Herrmann C, Koralov SB, Cadwell K, Graham AL, Loke P.

Nat Immunol. 2024 Jul;25(7):1270-1282. Epub...

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Distinct SIV-Specific CD8+ T Cells in the Lymph Node Exhibit Simultaneous Effector and Stem-Like Profiles and Are Associated With Limited SIV Persistence

Strongin Z, Raymond Marchand L, Deleage C, Pampena MB, Cardenas MA, Beusch CM, Hoang TN, Urban EA, Gourves M, Nguyen K, Tharp GK, Lapp S, Rahmberg AR, Harper J, Del Rio Estrada PM, Gonzalez-Navarro M, Torres-Ruiz F, Luna-Villalobos YA, Avila-Rios...

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Mast Cell Secretory Granule Fusion With Amphisomes Coordinates Their Homotypic Fusion and Release of Exosomes

Omari S, Roded A, Eisenberg M, Ali H, Fukuda M, Galli SJ, Sagi-Eisenberg R.

Cell Rep. 2024 Jul 23;43(7):114482. Epub 2024 Jul 9. PMID: 38985670 

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Wriggly Woes: Helminths Stirring Up T Cell Trouble

Pondevida CM, Jay A, Vahedi G.

Immunity. 2024 Aug 13;57(8):1726-1728. PMID: 39142272

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DCAF15 Control of Cohesin Dynamics Sustains Acute Myeloid Leukemia

Grothusen GP, Chang R, Cao Z, Zhou N, Mittal M, Datta A, Wulfridge P, Beer T, Wang B, Zheng N, Tang HY, Sarma K, Greenberg RA, Shi J, Busino L.

Nat Commun. 2024 Jul 3;15(1):5604. PMID: 38961054 

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LAG-3 Sustains TOX Expression and Regulates the CD94/NKG2-Qa-1b Axis to Govern Exhausted CD8 T Cell NK Receptor Expression and Cytotoxicity

Ngiow SF, Manne S, Huang YJ, Azar T, Chen Z, Mathew D, Chen Q, Khan O, Wu JE, Alcalde V, Flowers AJ, McClain S, Baxter AE, Kurachi M, Shi J, Huang AC, Giles JR, Sharpe AH, Vignali DAA,...

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