Key Publications
A Multivalent mRNA-LNP Vaccine Protects Against Clostridioides Difficile Infection
Alameh MG, Semon A, Bayard NU, Pan YG, Dwivedi G, Knox J, Glover RC, Rangel PC, Tanes C, Bittinger K, She Q, Hu H, Bonam SR, Maslanka JR, Planet PJ, Moustafa AM, Davis B, Chevrier A, Beattie M, Ni H,...
Read Moreabout A Multivalent mRNA-LNP Vaccine Protects Against Clostridioides Difficile InfectionImproved Influenza Vaccine Responses After Expression of Multiple Viral Glycoproteins From a Single mRNA
Leonard RA, Burke KN, Spreng RL, Macintyre AN, Tam Y, Alameh MG, Weissman D, Heaton NS.
Nat Commun. 2024 Oct 8;15(1):8712. PMID: 39379405
Read Moreabout Improved Influenza Vaccine Responses After Expression of Multiple Viral Glycoproteins From a Single mRNACirculating KRAS G12D But Not G12V is Associated With Survival in Metastatic Pancreatic Ductal Adenocarcinoma
Till JE, McDaniel L, Chang C, Long Q, Pfeiffer SM, Lyman JP, Padrón LJ, Maurer DM, Yu JX, Spencer CN, Gherardini PF, Da Silva DM, LaVallee TM, Abbott C, Chen RO, Boyle SM, Bhagwat N, Cannas S, Sagreiya H, Li...
Read Moreabout Circulating KRAS G12D But Not G12V is Associated With Survival in Metastatic Pancreatic Ductal AdenocarcinomaAn Iron-Rich Subset of Macrophages Promotes Tumor Growth Through a Bach1-Ednrb Axis
Folkert IW, Molina Arocho WA, To TKJ, Devalaraja S, Molina IS, Shoush J, Mohei H, Zhai L, Akhtar MN, Kochat V, Arslan E, Lazar AJ, Wani K, Israel WP, Zhang Z, Chaluvadi VS, Norgard RJ, Liu Y, Fuller AM, Dang...
Read Moreabout An Iron-Rich Subset of Macrophages Promotes Tumor Growth Through a Bach1-Ednrb AxisSenescent Cancer-Associated Fibroblasts in Pancreatic Adenocarcinoma Restrict CD8+ T Cell Activation and Limit Responsiveness to Immunotherapy in Mice
Assouline B, Kahn R, Hodali L, Condiotti R, Engel Y, Elyada E, Mordechai-Heyn T, Pitarresi JR, Atias D, Steinberg E, Bidany-Mizrahi T, Forkosh E, Katz LH, Benny O, Golan T, Hofree M, Stewart SA, Atlan KA, Zamir G, Stanger BZ...
Read Moreabout Senescent Cancer-Associated Fibroblasts in Pancreatic Adenocarcinoma Restrict CD8+ T Cell Activation and Limit Responsiveness to Immunotherapy in MiceTransdifferentiation Occurs Without Resetting Development-Specific DNA Methylation, a Key Determinant of Full-Function Cell Identity
Radwan A, Eccleston J, Sabag O, Marcus H, Sussman J, Ouro A, Rahamim M, Azagury M, Azria B, Stanger BZ, Cedar H, Buganim Y.
Proc Natl Acad Sci U S A. 2024 Sep 24;121(39):e2411352121. Epub 2024 Sep 18. PMID: 39292740
Read Moreabout Transdifferentiation Occurs Without Resetting Development-Specific DNA Methylation, a Key Determinant of Full-Function Cell IdentityTwo Clinical Trials Assessing Treatments for Eosinophilic Esophagitis
Chehade M, Dellon ES, Spergel JM.
N Engl J Med. 2024 Sep 19;391(11):1066-1067. PMID: 39292938
Read Moreabout Two Clinical Trials Assessing Treatments for Eosinophilic EsophagitisModified C-Type Natriuretic Peptide Normalizes Tumor Vasculature, Reinvigorates Antitumor Immunity, and Improves Solid Tumor Therapies
Lu Z, Verginadis I, Kumazoe M, Castillo GM, Yao Y, Guerra RE, Bicher S, You M, McClung G, Qiu R, Xiao Z, Miao Z, George SS, Beiting DP, Nojiri T, Tanaka Y, Fujimura Y, Onda H, Hatakeyama Y, Nishimoto-Ashfield...
Read Moreabout Modified C-Type Natriuretic Peptide Normalizes Tumor Vasculature, Reinvigorates Antitumor Immunity, and Improves Solid Tumor TherapiesImmunologic Signatures of Response and Resistance to Nivolumab With Ipilimumab in Advanced Metastatic Cancer
Tsimberidou AM, Alayli FA, Okrah K, Drakaki A, Khalil DN, Kummar S, Khan SA, Hodi FS, Oh DY, Cabanski CR, Gautam S, Meier SL, Amouzgar M, Pfeiffer SM, Kageyama R, Yang E, Spasic M, Tetzlaff MT, Foo WC, Hollmann TJ,...
Read Moreabout Immunologic Signatures of Response and Resistance to Nivolumab With Ipilimumab in Advanced Metastatic CancerProton Radiation Boosts the Efficacy of Mesothelin-Targeting Chimeric Antigen Receptor T Cell Therapy in Pancreatic Cancer
Amit U, Uslu U, Verginadis II, Kim MM, Motlagh SAO, Diffenderfer ES, Assenmacher CA, Bicher S, Atoche SJ, Ben-Josef E, Young RM, June CH, Koumenis C.
Proc Natl Acad Sci U S A. 2024 Jul 30;121(31):e2403002121.Epub 2024 Jul 24. PMID: 39047033
Read Moreabout Proton Radiation Boosts the Efficacy of Mesothelin-Targeting Chimeric Antigen Receptor T Cell Therapy in Pancreatic CancerCAR T Cell Combination Therapies to Treat Cancer
Uslu U, Castelli S, June CH.
Cancer Cell. 2024 Aug 12;42(8):1319-1325. Epub 2024 Jul 25. PMID: 39059390
Read Moreabout CAR T Cell Combination Therapies to Treat CancerIntestinal cDC1s Provide Cues Required for CD4+ T Cell-Mediated Resistance to Cryptosporidium
Cohn IS, Wallbank BA, Haskins BE, O'Dea KM, Pardy RD, Shaw S, Merolle MI, Gullicksrud JA, Christian DA, Striepen B, Hunter CA.
J Exp Med. 2024 Jul 1;221(7):e20232067. Epub 2024 Jun 3. PMID: 38829369
Read Moreabout Intestinal cDC1s Provide Cues Required for CD4+ T Cell-Mediated Resistance to CryptosporidiumClonal Hematopoiesis Driven by Mutated DNMT3A Promotes Inflammatory Bone Loss
Wang H, Divaris K, Pan B, Li X, Lim JH, Saha G, Barovic M, Giannakou D, Korostoff JM, Bing Y, Sen S, Moss K, Wu D, Beck JD, Ballantyne CM, Natarajan P, North KE, Netea MG, Chavakis T, Hajishengallis G....
Read Moreabout Clonal Hematopoiesis Driven by Mutated DNMT3A Promotes Inflammatory Bone LossUse of 3M-052-AF With Alum Adjuvant in HIV Trimer Vaccine Induces Human Autologous Neutralizing Antibodies
Hahn WO, Parks KR, Shen M, Ozorowski G, Janes H, Ballweber-Fleming L, Woodward Davis AS, Duplessis C, Tomai M, Dey AK, Sagawa ZK, De Rosa SC, Seese A, Kallur Siddaramaiah L, Stamatatos L, Lee WH, Sewall LM, Karlinsey D, Turner...
Read Moreabout Use of 3M-052-AF With Alum Adjuvant in HIV Trimer Vaccine Induces Human Autologous Neutralizing AntibodiesGenetic and Environmental Interactions Contribute to Immune Variation in Rewilded Mice
Oyesola O, Downie AE, Howard N, Barre RS, Kiwanuka K, Zaldana K, Chen YH, Menezes A, Lee SC, Devlin J, Mondragón-Palomino O, Souza COS, Herrmann C, Koralov SB, Cadwell K, Graham AL, Loke P.
Nat Immunol. 2024 Jul;25(7):1270-1282. Epub...
Read Moreabout Genetic and Environmental Interactions Contribute to Immune Variation in Rewilded MiceDistinct SIV-Specific CD8+ T Cells in the Lymph Node Exhibit Simultaneous Effector and Stem-Like Profiles and Are Associated With Limited SIV Persistence
Strongin Z, Raymond Marchand L, Deleage C, Pampena MB, Cardenas MA, Beusch CM, Hoang TN, Urban EA, Gourves M, Nguyen K, Tharp GK, Lapp S, Rahmberg AR, Harper J, Del Rio Estrada PM, Gonzalez-Navarro M, Torres-Ruiz F, Luna-Villalobos YA, Avila-Rios...
Read Moreabout Distinct SIV-Specific CD8+ T Cells in the Lymph Node Exhibit Simultaneous Effector and Stem-Like Profiles and Are Associated With Limited SIV PersistenceMast Cell Secretory Granule Fusion With Amphisomes Coordinates Their Homotypic Fusion and Release of Exosomes
Omari S, Roded A, Eisenberg M, Ali H, Fukuda M, Galli SJ, Sagi-Eisenberg R.
Cell Rep. 2024 Jul 23;43(7):114482. Epub 2024 Jul 9. PMID: 38985670
Read Moreabout Mast Cell Secretory Granule Fusion With Amphisomes Coordinates Their Homotypic Fusion and Release of ExosomesWriggly Woes: Helminths Stirring Up T Cell Trouble
Pondevida CM, Jay A, Vahedi G.
Immunity. 2024 Aug 13;57(8):1726-1728. PMID: 39142272
Read Moreabout Wriggly Woes: Helminths Stirring Up T Cell TroubleDCAF15 Control of Cohesin Dynamics Sustains Acute Myeloid Leukemia
Grothusen GP, Chang R, Cao Z, Zhou N, Mittal M, Datta A, Wulfridge P, Beer T, Wang B, Zheng N, Tang HY, Sarma K, Greenberg RA, Shi J, Busino L.
Nat Commun. 2024 Jul 3;15(1):5604. PMID: 38961054
Read Moreabout DCAF15 Control of Cohesin Dynamics Sustains Acute Myeloid LeukemiaLAG-3 Sustains TOX Expression and Regulates the CD94/NKG2-Qa-1b Axis to Govern Exhausted CD8 T Cell NK Receptor Expression and Cytotoxicity
Ngiow SF, Manne S, Huang YJ, Azar T, Chen Z, Mathew D, Chen Q, Khan O, Wu JE, Alcalde V, Flowers AJ, McClain S, Baxter AE, Kurachi M, Shi J, Huang AC, Giles JR, Sharpe AH, Vignali DAA,...
Read Moreabout LAG-3 Sustains TOX Expression and Regulates the CD94/NKG2-Qa-1b Axis to Govern Exhausted CD8 T Cell NK Receptor Expression and Cytotoxicity