Allergy, Asthma and Other Inflammatory Diseases

While inflammation is an essential and important part of the physiological and immunological response to infection and tissue injury, prolonged or mis-directed inflammatory responses can drive pathological outcomes. Examples of pathological inflammatory responses include: allergy and asthma, sepsis, respiratory distress, cardiovascular disease, autoimmunity and some forms of cancer. IFI researchers interrogate human and rodent systems to understand how the balance between protective vs. pathologic inflammation is regulated, with the ultimate goal of identifying pathways that can be therapeutically targeted to re-direct the course of infectious, inflammatory and metabolic disease.