The LBI brings together investigators and clinicians to foster cutting edge research projects of an interdisciplinary nature. Here we spotlight some of the groundbreaking research that has come out of these collaborations.
1. A novel human lung cell type that may play a key role in human lung diseases has been discovered by LBI researchers.
Human distal airways contain a multipotent secretory cell that can regenerate alveoli. Basil MC, Cardenas-Diaz FL, Kathiriya JK, Morley MP, Carl J, Brumwell AN, Katzen J, Slovik KJ, Babu A, Zhou S, Kremp MM, McCauley KB, Li S, Planer JD, Hussain SS, Liu X, Windmueller R, Ying Y, Stewart KM, Oyster M, Christie JD, Diamond JM, Engelhardt JF, Cantu E, Rowe SM, Kotton DN, Chapman HA, Morrisey EE. Nature 2022 Apr;604(7904):120-126. doi: 10.1038/s41586-022-04552-0. Epub 2022 Mar 30. PMID: 35355013.
2. A multidisciplinary LBI team developed DART (dual affinity to RBCs and target cells), which significantly increases both specificity and reduces toxicity of drugs being targeted via nanocarriers which could improve therapies in the future.
Dual Affinity to RBCs and Target Cells (DART) Enhances Both Organ- and Cell Type-Targeting of Intravascular Nanocarriers. Ferguson LT, Hood ED, Shuvaeva T, Shuvaev VV, Basil MC, Wang Z, Nong J, Ma X, Wu J, Myerson JW, Marcos-Contreras OA, Katzen J, Carl JM, Morrisey EE, Cantu E, Villa CH, Mitragotri S, Muzykantov VR, Brenner JS. ACS Nano 2022 Mar 22;16(3):4666-4683.doi: 10.1021/acsnano.1c11374. Epub 2022 Mar 10. PMID: 35266686.
3. A Multi-Institutional collaboration yields new insight into the role that Neuropeptides play in human lung diseases.
Excess neuropeptides in lung signal through endothelial cells to impair gas exchange. Xu J, Xu L, Sui P, Chen J, Moya EA, Hume P, Janssen WJ, Duran JM, Thistlewaite P, Carlin A, Gulleman P, Banaschewski B, Goldy MK, Yuan JX, Malhotra A, Pryhuber G, Crotty-Alexander L, Deutsch G, Young LR, Sun X. Dev Cell 2022 Mar 11;S1534-5807(22)00125-3. PMID: 35303432.
4. Perelman School of Medicine researchers have designed a novel utilitization of CAR T cells and set the stage for a novel therapeutic platform to treat diseases including cardiopulmonary diseases.
CAR T cells produced in vivo to treat cardiac injury. Rurik JG, Tombacz I, Yadegari A, Fernandez POM, Shewale SV, Li L Kimura T, Soliman OY, Papper TE, Tam YK, Mui BL, Albelda SM, Pure E, June CH, Aghajanian H, Weissman D, Parhiz H, Epstein JA. Science 2022 2022 Jan 7;375(6576):91-96.doi: 10.1126/science.abm0594. Epub 2022 Jan 6. PMID: 3499023.