The Penn-CHOP Lung Biology Institute (LBI) is dedicated to advancing research and treatment for lung diseases, which are the third leading cause of illness and death in the U.S. The COVID-19 pandemic has highlighted the urgent need for better understanding and innovative treatments for respiratory conditions. The LBI brings together clinicians, researchers, and experts from various fields to explore the mechanisms of lung diseases and apply these insights to improve clinical care. Key goals include fostering collaboration in pulmonary research, facilitating translational research focused on human-related studies, and providing exceptional education and training for future leaders in the field of pulmonary medicine and research.