Open Position: Molecular Biologist for Stem Cell Research

Position Summary

The Lei-Markmann Laboratory Group is hiring Molecular Biologists for stem cell research projects aimed at advancing cell therapies for Type 1 diabetes. We seek postdoctoral candidates with a strong interest in developmental and pancreatic islet biology and expertise in molecular biology. The ideal candidate is scientifically independent, proactive, and demonstrates strong communication, organizational, and multitasking skills.

Key Responsibilities

Implement SOPs, perform cell culture, and design exploratory research to generate stem cell-derived islets (SC-islets) and/or advance islet cell biology. Utilize in vivo transplantation models in small and large animals, including nonhuman primates, alongside cell-based assays to assess the characteristics of stem cells and function of SC-islets. Apply a range of techniques—including gene engineering, gene expression analysis, single-cell RNA sequencing, spatial transcriptomics (spatial Seq), and bioinformatics—to investigate the fate of stem cells and differentiated SC-islets, driving advancements in beta cell replacement. Collaborate with cross-functional teams to plan, coordinate, and execute experiments. Present findings internally and externally.

Scientific and Non-scientific Skills

Experience in molecular biology and molecular immunology techniques, including but not limited to gene engineering, single-cell RNA sequencing, and cell lineage tracing. Proficiency in cell-based assays such as gene expression analysis (e.g., qPCR, Nanostring) and flow cytometry. Familiarity with computational biology and its applications. Experience in differentiating pluripotent stem cells (hESC and/or hiPSC) into functional islets is desirable. A proven track record of publications is required.

Preferred Education and Experience Levels

Ph.D. in Molecular and Cell Biology or related disciplines and 0-3 years of relevant post-doctoral working experience.

Contact: Ji.Lei@pennmedicine.upenn.edu