Welcome to The Mach Lab

Our program focuses on the development of novel probes for use with the molecular imaging technique, positron emission tomography (PET). 

[18F]FTT PET Binding and Blockade by the PARP Inhibitor Olaparib Predicts Response Therapy and Progression-Free Survival (PFS)

A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibris in Multiple System Atrophy

[18F]ROStrace oxidative stress images in APP/PS1 mice

Identified lead compounds from virtual screening to in vivo imaging

The Radiopharmaceutical Chemistry and Biology Lab uses basic principles of medicinal chemistry and structural biology in the design and optimization of probes for use in preclinical and translational imaging studies. Current research focuses mostly on radiotracers for imaging PARP-1 expression in tumors ([18F]FTT), cell proliferation and quiescence ([18F]ISO-1) oxidative stress ([18F]ROStrace), dopamine receptor dysregulation, and abnormal protein aggregation in neurodegenerative disorders such as alpha synuclein in Parkinson’s disease.

Recent Award

Lab member Anthony Young received the Alavi-Mandell Award for the publication “Kinetic Analysis and Metabolism of Poly(Adenosine Diphosphate–Ribose) Polymerase-1–Targeted 18F-Fluorthanatrace PET in Breast Cancer”. This award recognizes trainees who made a major contribution as first authors to papers published in The Journal of Nuclear Medicine (JNM). It aims to encourage their pursuit of careers in academic research in nuclear medicine.