Research
Molecular Imaging of Proteinopathy in Neurodegenerative Disease - Nasrallah
Alzheimer’s disease is the most common neurodegenerative cause of dementia and is characterized by the accumulation of amyloid plaques and tau protein-containing neurofibrillary tangles. Both of these protein deposits (‘proteinopathies’) can be measured using PET imaging. The laboratory has collaborative studies investigating the relationships between amyloid and tau depositions and effects on brain structure, as measured by MR. We aim to leverage advanced image analytic methods, in collaboration with researchers at the Center for Biomedical Image Computing and Analytics at the University of Pennsylvania.
Imaging Sex Differences in Smoking-Induced Pulmonary Inflammation - Dubroff
Investigators are studying how the information from the PET/CT scan compares to other markers of inflammation in the blood. During the PET scan, Investigators will image Brain and Lungs in order to see if there is a difference between inflammation seen in the brain and the lungs and if these differences change depending on whether a subject is a non-smoker, smoker, e-cigarette user or mixed user.
Multitracer [18F]Fluciclovine and 18F-FDG PET, and Advanced MRI for Metabolic Profiling of Glioblastoma (GBM)- Nabavizadeh
Investigators are using [18F]Fluciclovine and [18F]FDG PET to characterize newly diagnosed and recurrent Glioblastoma (GBM) brain tumors. PET measurements will be compared to MRI quantification measures of glutamate and lactate levels as well as tumor tissue laboratory assays (RNA seq and proteomics) of glutamine/glutamate, glucose, and lactate metabolism.