Department of Neurology
Celebrating 150 Years of Advances and Achievements
1860
1860 — 1871
Pre 1871 --- What was happening: Benjamin Rush, Civil War
Diversity
Diversity
The College was chartered.Two Mohawk Indian brothers, Jonathan and Philip Gayienquitioga, attended the Academy of Philadelphia. They are the first Native Americans to attend what became the University of Pennsylvania and were joined in 1756 by another Indian, John Montour, who studied English
1862
First Modern Welfare State
First Modern Welfare State
OTTO VON BISMARCK CREATES EUROPE'S. FIRST MODERN WELFARE STATE- NATIONAL HEALTH CARE (1883) AND OLD AGE PENSION (1889)
1863
EMANCIPATION PROCLAMATION
EMANCIPATION PROCLAMATION
EMANCIPATION PROCLAMATION CHANGED LEGAL STATUS OF 3.5 MILLION ENSLAVED BLACKS IN CONFEDERATE STATES
1870
Nation's First Neurology Department in USA
Nation's First Neurology Department in USA
Instantiation of the first neurology department in the USA at the university of Pennsylvania
1871
1871 — 1900
Horatio C. Wood, Chair
1875
ANA Founded
ANA Founded
American Neurological Association (ANA) is founded by William Hammond and S. Weir Mitchell
1878
First Issue of Brain published
First Issue of Brain published
First issue of Brain is published, founded by John Hughlings Jackson, David Ferrier, and Sir James Crichton-Browne
1879
First African American Students
First African American Students
The first African American students enrolled at Penn: William Adger, James Brister, Nathan Mossell
1880
First Female students admitted into degree programs
First Female students admitted into degree programs
The first female students admitted into degree programs were Mary Alice Bennett, M.D. and Anna H. Johnson, to the School of Auxiliary Medicine. Bennett received a degree of Doctor of Philosophy in June, becoming the first woman to receive a degree from the University of Pennsylvania
1881
Nations First Business School Created (Wharton)
Nations First Business School Created (Wharton)
Wharton Business School - the world’s first collegiate business school created
Continue reading about Nations First Business School Created (Wharton)
1882
First African American to graduate Penn's School of Medicine
First African American to graduate Penn's School of Medicine
Nathan Francis Mossell becomes first African-American man to graduate from Penn School of Medicine
1883
FIRST AFRICAN AMERICAN WOMAN TO GRADUATE MEDICAL SCHOOL
FIRST AFRICAN AMERICAN WOMAN TO GRADUATE MEDICAL SCHOOL
REBECCA LEE CRUMPLER FIRST AFRICAN AMERICAN WOMAN TO GRADUATE MEDICAL SCHOOL IN THE US. IN 1883 SHE PUBLISHES "A BOOK OF MEDICAL DISCOURSES" FOCUSED ON MATERNAL AND PEDIATRIC CARE.
1886
Effects of Alcohol
Effects of Alcohol
1886- First identification of effects of alcohol on the nervous system: Alcoholic Polyneuropathy with Special Psychic Phenomena, Charles K. Mills,
1888
Mills work on motor and sensory brain areas
Mills work on motor and sensory brain areas
Charles Mills delineates how motor and sensory areas in the brain were distinct and used electrical stimulation to help localize functions of specific regions in the brain.
1890
First X-Ray Picture
First X-Ray Picture
The first X-Ray picture is taken by Professor Arthur W. Goodspeed of Physics and photographer William N. Jennings
1897
Nation's First at Rehabilitation Department
Nation's First at Rehabilitation Department
The nation’s first Department of Rehabilitation Services is founded at HUP
Nation's First Radiology Department
Nation's First Radiology Department
The nation’s first Department of Radiology is founded at HUP, then called the Division of Roentgenology Services
1898
First Major Neurology Text
First Major Neurology Text
First major neurology text in the US: The Nervous System and Its Diseases, Contains his original work on cerebral localization, including via electrical cortical stimulation of Fraser in Neurosurgery. Charles K. Mills.
1900
Mills Syndrome
Mills Syndrome
First Description of Mills syndrome A Case of Unilateral Progressive Ascending Paralysis, Probably Representing a New Form of Degenerative Disease. The journal of nervous and mental disease 27(4):p 195-200, Description of Mills syndrome, April
1900 — 1915
Charles Mills, Chair
1902
1906
Neuro-Ophthalmology Text Book
Neuro-Ophthalmology Text Book
1st text on neuro-ophthalmology - The Eye and the Nervous System, W. Campbell Posey, William G. Spiller
1915
1915 — 1937
William G. Spiller, Chair
1918
Aberrant Regeneration
Aberrant Regeneration
First description of aberrant regeneration following facial paralysis-- Spiller, W.G.
1937
Philadelphia Orthopedic Hospital Merger
Philadelphia Orthopedic Hospital Merger
Philadelphia Orthopedic Hospital and Infirmary for Nervous Diseases, a leading center for neurologic research in the early 20th century, merged into the University of Pennsylvania.
Study on Pregnancy Effects on Ovulation
Study on Pregnancy Effects on Ovulation
Drs. A. E. Makepeace, George L. Weinstein, and Maurice Freidman study how pregnancy prevents ovulation, work that was foundational for the invention of “the pill” in 1960.
1937 — 1942
William Cadwalader, Chair
1940
Patent Application
Patent Application
Christian Lambertsen, M’43: applies for a patent for a self-contained underwater breathing apparatus (eventually known as SCUBA)
1942
1942 — 1962
George D. Gammon, Chair
1943
General Hospital Started in India
General Hospital Started in India
20th General Hospital is started in northeast India to treat American and Chinese forces fighting the Japanese in Burma. The 700-member hospital staff predominantly consists of Penn people, including Dr. I. S. Ravdin
1946
Penicillin Therapy in Neurosyphilis
Penicillin Therapy in Neurosyphilis
First report of efficacy of peniciilin in neurosyphilis: Penicillin Therapy Alone in Neurosyphilis: An Analysis of Clinical Results, George D. Gammon, m.d., f.a.c.p., John H. Stokes, m.d., Howard p. Steiger, Willard h. Steele, m.d., Herman Beerman, m.d., Norman r. Ingraham Jr., m.d., Paul Gyorgy, m.d., Elizabeth Rose, m.d., John W. Lentz, m.d., Abraham Ornsteen, m.d., f.a.c.p., Donald Scott, m.d. annals of internal medicine, Sept.
Penicillin Therapy developed
Penicillin Therapy developed
A landmark interventional trial with Penicillin single therapy for neurosyphilis was conducted in the department as part of the Penicillin-Syphillis group, published in JAMA in 1946. Penicillin was purified a mere six years earlier and in the early 1940s was established as the most effective treatment for early-stage disease. The study lead by Dr. Stokes, Dr. Steiger and Dr. Gammon, showed an overall improvement of symptoms and CSF indices in 65% of symptomatic neurosyphilis cases.
1961
First of many .... NIH Program
First of many .... NIH Program
First NIH Program Project Grant (re Neuromuscular Disorders) (G. Milton Shy)
1st NIH Training for residency program
1st NIH Training for residency program
1961-First NIH Training Grant to support residency training (G. Milton Shy)
1962
1962 — 1967
G. Milton Shy, Chair
1st Full time appointment in a clinical dept developed
1st Full time appointment in a clinical dept developed
Dr. Shy’s appointment at Penn represented the first ‘full time’, i.e. fully-salaried faculty position in a clinical department at the University of Pennsylvania.
PET Scan developed
PET Scan developed
Isotope Brain Scanning, and then Positron Emission Tomographic brain scanning were developed. The basic work for PET was done at Penn by David Kuhl.
First NIH training Grant
First NIH training Grant
First NIH Training Grant to support residency training 1962 (G. Milton Shy)
1963
Cortical Neurons
Cortical Neurons
First Goldensohn ED, Purpura DP. Intracellular Potentials of Cortical Neurons During Focal Epileptogenic Discharges. Science Mar;1;139(3557):840-842,
Measles Vaccine released
Measles Vaccine released
Valium introduced Measles vaccine released Plasmapheresis procedure was perfected at the National Cancer Institute, NIH
1964
Pursuing Residencies
Pursuing Residencies
By 1964, more than 80 percent of the School of Medicine’s graduates pursued residency training in a clinical specialty
1st EMU (Neuro 1st)
1st EMU (Neuro 1st)
Development of the First Epilepsy Monitoring Unit 1964 (Eli Goldensohn) - Perhaps the first in the World
The origin of Triple Threat approach
The origin of Triple Threat approach
It was expected that each of the Neurology faculty at Penn would be engaged in research as well as clinical activities and teaching – the origin of the ‘triple threat’ faculty member. This approach represented the beginnings of translational research in academic departments of neurology in the U.S.
1965
First Clinical Course
First Clinical Course
First integrated Basic and Clinical Neurobiology Course in US, 1965 (Donald Silberberg, James Sprague)
Muscle Biopsies
Muscle Biopsies
Dr. Shy’s exploration of muscle biopsies via light microscopy, together with Dr. Gonatas’ expertise in electron microscopy yielded the original descriptions of several mitochondrial myopathies, assigned names by Dr. Gonatas such as ‘Nemaline myopathy, Megaconial myopathy and Pleoconial myopathy’.
1966
Innovations
Innovations
1966-1967: The 20-bed inpatient until remained on Ground Floor Gibson. HUP’s capacity in 1967 was 900 beds. Neurology’s outpatient visits totaled 3,175
1967
First Woman of Color in Neurology
First Woman of Color in Neurology
Dr. Audrey Penn joined the faculty at Penn as an instructor. In 1972, she was promoted to Associate Professor, becoming the first woman of color on faculty in the Neurology department.
Adult Training Program developed
Adult Training Program developed
1967-68: The adult training program included seven residents and one fellow. The program was expanded to three, and later four residents/yr. Child Neurology trained two/yr., each of whom spent their first year at HUP.
1967 — 1973
Lewis R. Rowland, Chair
1969
1st measurement of cerebral blood flow
1st measurement of cerebral blood flow
First measurement of cerebral blood flow in animals : Reivich, M., Jehle, J., Sokoloff, L., and Kety, S.S.: Measurement of regional cerebral blood flow with 14C antipyrine in awake cats. J. Appl. Physiol 27:296-300
1970
Established MS Center (Neuro 1st)
Established MS Center (Neuro 1st)
Established Comprehensive Multiple Sclerosis Center 1st in US (Donald Silberberg, Hilary Koprowski)
First Muscular Dystrophy Association
First Muscular Dystrophy Association
First Muscular Dystrophy Association Muscular Dystrophy Clinic in US established (Lewis. P. Rowland)
Hyperbilirubenia Treatment (Neuro 1st)
Hyperbilirubenia Treatment (Neuro 1st)
First description of hyperbilirubenia treatment with UV light: Silberberg DH, Johnson L, Schutta H. Effects of photodegredation products of bilirubin on myelinating cerebellum cultures. J Ped 77:6l3-6l8,
Watts Muscular Dystropy Research Center Developed
Watts Muscular Dystropy Research Center Developed
The Watts Muscular Dystrophy Research Center was developed, one of the first recognized by the Muscular Dystrophy Association.
Specialty Treatment Demands
Specialty Treatment Demands
By 1970, the demand for levodopa treatment was enormous, and Penn’s flagship Hospital of the University of Pennsylvania (HUP) was flooded with severely disabled parkinsonian patients
1973
Cerebrovascular Research Center (Neuro 1st)
Cerebrovascular Research Center (Neuro 1st)
First Cerebrovascular Research Center (CVRC) established by Martin Reivich among the first established by NINDS. The CVRC collaborated with investigators in various departments and schools at Penn and other institutions around the world, including Semmelweis University in Budapest and Keio University in Tokyo.
1974
1974 — 1982
Arthur K. Asbury, Chair
Full-Time Neurologists
Full-Time Neurologists
In 1974 the Department of Neurology had nineteen full-time neurologists, along with roughly two dozen affiliated clinical faculty members.
1975
Onyx Senior Honor Society
Onyx Senior Honor Society
1975: the Onyx Senior Honor Society formed to recognize outstanding African American Students.
1977
Duchenne Muscular Dystrophy
Duchenne Muscular Dystrophy
First description of anatomical alterations in Duchenne muscular dystrophy. Duchenne dystrophy: alteration in muscle plasma membrane structure DL Schotland, E Bonilla, M Van Meter, Science 196 (4293), 1005-1007
1978
Immunologic Marker
Immunologic Marker
First immunologic marker for oligodendroglia - Raff M, Mersky R, Fields K, Lisak RP, Dorfman SH, Silberberg DH, Gregson N, Leibowitz S. Galactocerebroside is a specific cell-surface antigenic marker for oligodendrocytes in culture. Nature 274:8l3-8l6
1979
First PET Center
First PET Center
First PET center first FDG-PET studies in man measuring regional brain glucose utilization - The Positron Emission Tomography (PET) Center, including a cyclotron facility, was established in 1979, by Martin Reivich, funded by NINDS.
1980
Funding Sources created
Funding Sources created
In the early 1980s, with the use of what were termed ‘Education and Development Funds’ that the department had accrued, Neurology was able to share in building the Clinical Research building and thus was able to reserve and equipped the research space that it occupies in the CRB.
Outpatients
Outpatients
By 1980 there were over 7, 000 outpatients and 1,600 consultations at HUP, with more than 7,000 additional outpatients and roughly 3,000 consultations at Graduate, Pennsylvania, and Presbyterian combined.
New Positions in Neurology
New Positions in Neurology
By 1980 the program had expanded to 17 positions in adult neurology, with six positions in child neurology at CHOP and three additional positions based at Pennsylvania Hospital. Women (who then comprised 20% of the program’s adult and pediatric residents combined) were actively recruited with the goal of broadening the pipeline to careers in academic medicine, and they began to join the ranks of junior faculty at Penn and elsewhere.**(Over ninety percent of those who graduated from the residency program during those years continued in academia through a fellowship and/or faculty position.) A four-year training program with the Department of Medicine whereby the first year entailed a HUP medical internship—now commonplace but then unheard-of at Penn—was inaugurated with great success.
1981
Guillain-Barré Syndrome
Guillain-Barré Syndrome
Established the criteria for the diagnosis of Guillain-Barré syndrome(determined by the committee he chaired for the National Institute of Neurological Disorders and Stroke) in “Diagnostic considerations in Guillain-Barré syndrome” in Annals of Neurology
1982
Research Labs
Research Labs
In 1982, research laboratories were housed in the Johnson Pavillion, the Stemmler Building, and the cyclotron facility established by Dr. Martin Reivich on a below-ground floor of the Nurses Education Building. Dr. David Pleasure’s research was carried out in laboratories in CHOP.
1982 — 1994
Donald H. Silberberg, Chair
1983
Varicellar Zostr
Varicellar Zostr
First identification of Varicellar Zostr in human ganglia-Gilden, D.H., Vafai, A, Shtram, Y., Becker, Y., Devlin, M., Wellish, M.: Varice\la zoster virus DNA in human sensory ganglia. Nature 306:478-480,
1985
Awards
Awards
Jin-Moo Lee, MD, PhD -1997; Dianna Quan, MD - 1998; Susan R. Cowdery, MD -1999; Brenda E. Porter, MD, PhD - 2000
Awards
Awards
Robert P Lisak MD, -1985; Robert R. Clancy, MD - 1986; Norman J. Schatz, MD - 1987; David E. Pleasure, MD - 1988; Mark J. Brown, MD - 1989; Steven L. Galetta, MD - 1990; Donald L. Schotland, MD - 1991; Shawn J. Bird, MD - 1992; Donald H. Silberberg, MD - 1993; Lawrence G. Gray, OD -1994
1986
1987
Gadolinium – 1st description
Gadolinium – 1st description
The first demonstration of Gadolinium enhancement of active MS lesions
1989
Innovation
Innovation
Presbyterian Hospital’s neurology service was headed by Myron Frederic, joined in1970 by Sami Kella. It’s relationship to Penn’s Department of Neurology was chiefly to host medical students for electives, a favorite rotation. On January 1, 1989, the hospital was renamed the Presbyterian Medical Center of Philadelphia, and fully merged with the University of Pennsylvania Health System, becoming the Penn Presbyterian Medical Center on June 30, 1995
1992
1993
Cognitive Clinic created
Cognitive Clinic created
Established first Cognitive Neurology Clinic in US, 1993 (Murray Grossman)
Guillain Barre Syndrome
Guillain Barre Syndrome
1993-1996 -First description of Guillain Barre syndrome in a Chinese cohort-McKhann, G.M., Cornblath, D.R., Griffin, J.W., Ho, T.W., Li, C.Y., Jiang, Z., Wu, H.S., Zhaori, G., Liu, Y., Jou, L.P., Acute motor axonal neuropathy - a frequent cause of acute flaccid paralysis in China. Ann. Neurol. 33, 333-342
1994
CMT Mechanism
CMT Mechanism
1994- 1995 First identification of CMT mechanism- Bruzzone, R., T.W. White, S.S. Scherer, Fischbeck, K.H., and Paul, D.L. Null mutations of connexin32 in patients with X-linked Charcot-Marie-Tooth disease. Neuron 13, 1253-1260,
1995
1995 — 1999
Robert L. Barchi, Chair
First Use of fMRI
First Use of fMRI
1995-1996- First use of fMRI to describe cognitive function Aguirre, G.K., J.A. Detre, D.C. Alsop and M. D'Esposito,The parahippocampus subserves topographical learning in humans. Cereb. Cortex, 6: 823-829, Among the first cognitive fMRI papers. Prior work focused mostly on sensorimotor function.
Awards
Awards
Mark D'Esposito, MD -1995; John T. Sladky, MD - 1995; Alan C. Posenquist, PhD -1996; Arthur K. Asbury, MD -1997; Robert A. Barchi, MD - 1998; Jacqueline A. French, MD - 1999
Awards
Awards
John T. Sladky, MD - 1995; Mark D'esposito, MD - 1995; Alan C. Posenquist, PhD - 1996; Arthur K. Asbury, MD - 1997; Robert A. Barchi, MD, PhD - 1998; Jacqueline A. Grench, MD - 1999
1996
Temporal lobectomy
Temporal lobectomy
First outcomes study for temporal lobectomy for refractory epilepsy: outcome five years after surgery.
Non-fluent Aphasia
Non-fluent Aphasia
The first report characterizing the syndrome progressive non-fluent aphasia. Grossman, M., Mickanin, J., Onishi, K., Hughes, E., D'Esposito, M., Ding, X. S., et al. Progressive Nonfluent Aphasia: Language, Cognitive, and PET Measures Contrasted with Probable Alzheimer's Disease. Journal of Cognitive Neuroscience, 8(2), 135
FTLD-tau pathology
FTLD-tau pathology
The first report associating a clinical syndrome with FTLD-tau pathology - Turner, R. S., Kenyon, L. C., Trojanowski, J. Q., Gonatas, N., & Grossman, M. (1996). Clinical, neuroimaging, and pathologic features of progressive nonfluent aphasia. Annals of Neurology, 39(2), 166–173
1998
First ASL Patients
First ASL Patients
The first ASL in patients with chronic cerebrovascular disease. Arterial spin labeled perfusion MRI for noninvasive quantification of cerebral blood flow was conceived at Penn. This was the first ASL perfusion MRI in acute stroke.
1999
Merge of PAH and HUP
Merge of PAH and HUP
Merger of PAH and HUP neurology residencies and sequential expansion to 9 adult residents/year by 2010
1999 — 2010
Francisco González-Scarano, Chair
2000
PSOM Faculty Awards
PSOM Faculty Awards
Lindback Award, Arthur Asbury; Special Dean’s Award for Clinical Teaching, Scott Kasner;
Department Of Neurology Residents Award in Recognition of Excellence in Teaching
Department Of Neurology Residents Award in Recognition of Excellence in Teaching
Scott E. Kasner, MD - 2000; Shawn J. Bird, MD - 2001; Charles R. Cantor, MD - 2001; Richard S. Finkel, MD - 2001; Grant T. Liu, MD - 2002; Dennis J. Dlugos, MD - 2002; Susan T. Herman, MD - 2003; Rebecca N. Ichord, MD - 2003; David Solomon, MD - 2004; Carsten Bönnemann, MD - 2004; Josep O. Dalmau, MD, PhD - 2005; Donald P. Younkin - 2005; A.G Christina Bergqvist, MD - 2006; Amy A. Pruitt, MD - 2006; Stacy Horn, DO - 2007; Daniel J Licht, MD - 2007
2001
University of Pennsylvania Medical Center Department of Neurology Arthur K. Asbury Resident Award for Clinical Excellence
University of Pennsylvania Medical Center Department of Neurology Arthur K. Asbury Resident Award for Clinical Excellence
David A. Hinkle, MD, PhD - 2001; David A. Wolk, MD - 2002; Steven R. Messé, MD -2002; Joshua M. Levine, MD - 2003; Stephen Wong, MD - 2001; Beau M. Ances, MD, PhD - 2005; David J. Houghton, MD - 2006; Ellen M. Mowry, MD - 2007; Rachel Goldmann Gross, MD - 2008; Raymond Price, MD - 2008; Michael T. Mullen, MD - 2009; Jennifer Graves, MD, PhD - 2010
2002
Faculty Awards
Faculty Awards
Robert Dunning Dripps Memorial Teaching Award to Steve Galetta; Penn Pearls Awards Grant Liu
2003
Penn Pearls Awards 2003-2007
Penn Pearls Awards 2003-2007
2003 Penn Pearls Awards: Josh Levine (resident, now faculty) and Steve Galetta; 2004 Geoffrey Aguirre (resident, now faculty), Beau Ances (resident); 2005 Roy Hamilton (resident, now faculty), Gregory Wu (resident); 2007 Amy Pruitt, Peter Todd (resident)
2004
Master Clinician Award 2004-2009
Master Clinician Award 2004-2009
2004 Master Clinician Award to Howard I. Hurtig; 2009 Dr. Dan Litch(at CHOP); Dr. Rebecca Ichord (at CHOP)
National Neurology Awards
National Neurology Awards
Distinguished Neurology Teacher Award, American Neurological Association to Steve Galetta
2005
First Female Full Professor of Neurology
First Female Full Professor of Neurology
Dr. Jackie French becomes first female professor of Neurology
Steven L. Galetta, MD Outstanding Resident Teaching Award
Steven L. Galetta, MD Outstanding Resident Teaching Award
Roy H. Hamilton, MD - 2005; Sudha V. Kilaru, MD - 2006; Sarah E. Schmitt, MD - 2007; Sashank Prasad, MD - 2008; Peter E. Turkeltaub, MD, PhD - 2009; Vera Fridman, MD - 2010
Paraneoplastic Encephalitis
Paraneoplastic Encephalitis
First description of paraneoplastic encephalitis- Paraneoplastic Encephalitis, Psychiatric Symptoms, and Hypoventilation in Ovarian Teratoma Roberta Vitaliani, MD1, Warren Mason, MD2, Beau Ances, MD, PhD1, Theodore Zwerdling, MD3, Zhilong Jiang, PhD1, and Josep Dalmau, MD, PhD1 Ann Neurol. October ; 58(4): 594–604
2006
2007
Various Faculty Award
Various Faculty Award
Lindback Award, Amy Pruit; Alpha Omega Alpha Robert J. Glaser Distinguished Teacher Award, Association of American Medical Colleges to Steve Galetta;
Paradigm Shifts
Paradigm Shifts
Paradigm shift to use visual acuity, rather than radiographic features, to guide treatment decisions and as an primary outcome measure for clinical trials in children with optic pathway gliomas. This is now the standard of care nationally and internationally - Lister Listernick R, Ferner RE, Liu GT, Gutmann DH. Optic pathway gliomas in neurofibromatosis-1: controversies and recommendations. Ann Neurol 61:189-198,
Anti-NMDA Antibodies
Anti-NMDA Antibodies
First identicatoin of anti-NMDA antibodies in paraneoplastic disease- Paraneoplastic Anti–N-methyl-D-aspartate Receptor Encephalitis Associated with Ovarian Teratoma. Josep Dalmau, MD, PhD1, Erdem Tüzün, MD1, Haiyan Wu, PhD1, Jaime Masjuan, MD2,Jeffrey E. Rossi, BA1, Alfredo Voloschin, MD3, Joachim M. Baehring, MD4, Haruo Shimazaki,MD, PhD5, Reiji Koide, MD6, Dale King, MD7, Warren Mason, MD8, Lauren H. Sansing, MD1,Marc A. Dichter, MD, PhD1, Myrna R. Rosenfeld, MD, PhD1, and David R. Lynch, MD, PhD1 Ann Neurol. January ; 61(1): 25–36
2008
Department Of Neurology - Residents Award In Recognition Of Excellence In Teaching
Department Of Neurology - Residents Award In Recognition Of Excellence In Teaching
Gihan I.Tennekoon, MD - 2008; Steven L. Caletta, MD - 2008; Peter H. Berman, MD - 2009; Lauren B. Elman, MD - 2009; Laura J. Balcer, MD - 2010; Raymond Price, MD - 2010; Àmy T. Waldman, MD - 2010;
2009
Pathogenic Mutations
Pathogenic Mutations
First Identification of pathogenic mutations in ARX gene - Marsh E, Fulp C, Gomez E, Nasrallah I, et al. Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females. Brain. Jun;132(Pt 6):1563-76
Excellence in Clinical Teaching
Excellence in Clinical Teaching
Dr. Dennis Dlugos received the Dean’s Award for Excellence in Clinical Teaching at an affiliated hospital (CHOP)
Best Lecturer Award
Best Lecturer Award
Dr. Steven Galetta Class of 2011 Best Lecturer award and was inducted into the Gold Humanism Honor Society
2010
Fronto-Temporal Dementia
Fronto-Temporal Dementia
Established first Fronto-Temporal Dementia Clinic (Murray Grossman) - Development of clinical criteria for primary progressive aphasia
CSF Opening
CSF Opening
First Reference range for CSF opening pressures in children. The first prospective study - Avery RA, Shah SS, Licht DJ, Seiden JA, Huh JW, Boswinkel J, Ruppe MD, Chew A, Mistry RD, Liu GT. Reference range of cerebrospinal fluid opening pressure in children undergoing diagnostic lumbar puncture. N Engl J Med 363:891-893
2011
Awards
Awards
Colin Quinn, MD - 2011; Danielle Becker, MD - 2012; Caitlin Loomis, MD - 2013; Matthew Scharf, MD, PhD - 2013; Chloe E. Hill, MD - 2014; Megan B. Richie, MD - 2014; Cen Zhang, MD - 2015; Collin A. Ellis, MD - 2016; Christyn M. Emundson, MD - 2016; Ali G. Hamedani, MD - 2017; Noah Levinson, MD - 2018; Christopher Perrone, MD - 2018; Stephen Aradi, MD - 2019; Erin Conrad, MD - 2019
Development of Clinical Criteria
Development of Clinical Criteria
Development of clinical criteria for behavioral variant frontotemporal dementia Rascovsky, K., Hodges, J. R., Hodges, J. R., Knopman, D., Knopman, D., et al.. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain, 134(Pt 9), 2456–2477
Awards
Awards
Sarah Schmitt, MD - 2011; Sabrina Yum, MD - 2011; Nicholas Abend, MD - 2012; Joshua Levine MD - 2012; Sudha Kilaru Kessler, MD - 2013; Michael T. Mullen, MD - 2013; Lauren Elman, MD - 2014; Michael Rubenstein, MD - 2014; Lauren Elman, MD - 2015; Steven R. Messe, MD - 2015; Raymond S. Price, MD - 2016; Sharon A. Lewis, MD - 2016; Danielle Becker, MD, MS - 2017; Colin Quinn, MD - 2017; Jennifer Mcguire, MD, MSCE - 2017; Geoffrey K. Aguirre, MD, MSCE - 2017; Jay Pathmanathan, MD, PHD - 2018; Sudha Kessler, MD, MSCE - 2018; Sona Narula, MD - 2018; Donna Kurowski George, MD - 2019; Eric Lancaster, MD, PHD - 2019; Alyssa Rosen, MD - 2019; Christina Szperka, MD - 2019
2012
First to Segment the Retina
First to Segment the Retina
The first to segment the retina and correlate the importance of ganglion cell layer thickness to contrast letter acuity and quality of life in MS. This opened the door to the study of ganglion cell layer disease in relation to other neurological disorders - Walter SD, Ishikawa H, Galetta KM, Sakai RE, Feller DJ, Henderson SB, Wilson JA, Maguire MG, Galetta SL, Frohman E, Calabresi PA, Schuman JS, Balcer LJ. Ganglion cell loss in relation to visual disability in multiple sclerosis. Ophthalmology. Jun;119(6):1250-7
Awards
Awards
Ramani Balu, MD, PhD - 2012; Caitlin Loomis, MD - 2013; Megan B. Richie, MD - 2014; Grace C. Kimbaris, MD - 2015; Christyn M. Edmundson, MD - 2016; Donna Kurowski, MD - 2016; Kristina Patterson, MD, PhD - 2017; Kelley Humbert, MD - 2018
2012 — present
Frances Elizabeth Jensen, Chair
2013
First Director of the Consortium of Pediatric Neuro-Ohthalmologists
First Director of the Consortium of Pediatric Neuro-Ohthalmologists
Grant Liu - elected the first Director of the Consortium of Pediatric Neuro-ophthalmologists 2013-16.
2015
Contribution of Subclinical Seizures
Contribution of Subclinical Seizures
2015 Contribution of subclinical seizures to outcomes in critically ill children - Abend NS, Topjian AA, Williams S. Could EEG Monitoring in Critically Ill Children Be a Cost-effective Neuroprotective Strategy? J Clin Neurophysiol. Dec;32(6):486-94
Awards
Awards
Maxwell A. Greene, MD - 2015; David Do, MD - 2017; Elizabeth A. Kichula, MD, PhD - 2015; Jacqueline Gofshteyn, MD - 2017; Allie Massaro, MD - 2015; David C. Couchlin, MD - 2016; Ali G. Hamedani, MD - 2017; Christopher Perrone, MD - 2018; Taneeta Ganguly, MD - 2019; Christopher G. Favilla. MD - 2016; Gabriel R. Pilar, MD - 2016
Awards
Awards
Laura A. Stein, MD - 2015; Christopher M. Perrone, MD- 2016; Noah J. Levinson, MD - 2017; Noah J. Levinson, MD - 2017; Adys Mendizabal, MD - 2018; Daniel Cristancho, MD - 2019
2018
Penn Center for Neuroaesthetics
Penn Center for Neuroaesthetics
Penn Center for Neuroaesthetics, started 2018, Anjan Chatterjee
2019
2020
First Successful Treatment with Baricitinib
First Successful Treatment with Baricitinib
The first successful treatment with baricitinib of The Aicardi–Goutières syndrome, a genetic interferonopathy that is associated with severe disability and death - Vanderver A, Adang L, Gavazzi F, McDonald K, Helman G, Frank DB, Jaffe N, Yum SW, Collins A, Keller SR, Lebon P, Meritet JF, Rhee J, Takanohashi A, Armangue T, Ulrick N, Sherbini O, Koh J, Peer K, Besnier C, Scher C, Boyle K, Dubbs H, Kramer-Golinkoff J, Pizzino A, Woidill S, Shults J. Janus Kinase Inhibition in the Aicardi-Goutières Syndrome. N Engl J Med. Sep 3;383(10):986-989
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