Recent Publications

Wattenberg MM, Asch D, Yu S, O'Dwyer PJ, Domchek SM, Nathanson KL, Rosen MA, Beatty GL, Siegelman ES, Reiss KA. Platinum response characteristics of patients with pancreatic ductal adenocarcinoma and a germline BRCA1, BRCA2 or PALB2 mutation. British journal of cancer. 2020 February;122(3):333-339. PubMed PMID: 31787751; PubMed Central PMCID: PMC7000723; DOI: 10.1038/s41416-019-0582-7.

Brandstadter JD, Maillard I. Notch signalling in T cell homeostasis and differentiation. Open biology. 2019 November 29;9(11):190187. PubMed PMID: 31690218; PubMed Central PMCID: PMC6893402; DOI: 10.1098/rsob.190187.

Singh N, Lee YG, Shestova O, Ravikumar P, Hayer KE, Hong SJ, Lu XM, Pajarillo R, Agarwal S, Kuramitsu S, Orlando EJ, Mueller KT, Good CR, Berger SL, Shalem O, Weitzman MD, Frey NV, Maude SL, Grupp SA, June CH, Gill S, Ruella M. Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction. Cancer discovery. 2020 April;10(4):552-567. PubMed PMID: 32001516; PubMed Central PMCID: PMC7416790; DOI: 10.1158/2159-8290.CD-19-0813.

Billingsley MM, Singh N, Ravikumar P, Zhang R, June CH, Mitchell MJ. Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering. Nano letters. 2020 March 11;20(3):1578-1589. PubMed PMID: 31951421; PubMed Central PMCID: PMC7313236; DOI: 10.1021/acs.nanolett.9b04246.

Singh N, June CH. Boosting engineered T cells. Science (New York, N.Y.). 2019 July 12;365(6449):119-120. PubMed PMID: 31296754; PubMed Central PMCID: PMC7433348; DOI: 10.1126/science.aax6331.

Zintner SM, Small JC, Pavani G, Dankner L, Marcos-Contreras OA, Gimotty PA, Kjelgaard-Hansen M, Wiinberg B, Margaritis P. Gene-based FVIIa prophylaxis modulates the spontaneous bleeding phenotype of hemophilia A rats. Blood advances. 2019 February 12;3(3):301-311. PubMed PMID: 30705032; PubMed Central PMCID: PMC6373746; DOI: 10.1182/bloodadvances.2018027219.

Zafar A, Quadri SA, Farooqui M, Ikram A, Robinson M, Hart BL, Mabray MC, Vigil C, Tang AT, Kahn ML, Yonas H, Lawton MT, Kim H, Morrison L. Familial Cerebral Cavernous Malformations. Stroke. 2019 May;50(5):1294-1301. PubMed PMID: 30909834; PubMed Central PMCID: PMC6924279; DOI: 10.1161/STROKEAHA.118.022314.

Mack EA, Pear WS. Transcription factor and cytokine regulation of eosinophil lineage commitment. Current opinion in hematology. 2020 January;27(1):27-33. PubMed PMID: 31688456; PubMed Central PMCID: PMC7388079; DOI: 10.1097/MOH.0000000000000552.

Lövgren KM, Larsen MS, Zintner SM, Small JC, Kjelgaard-Hansen M, Häger M, Petersen M, Wiinberg B, Margaritis P. FVIII activity following FVIII protein infusion or FVIII gene transfer predicts the bleeding risk in hemophilia A rats. Journal of thrombosis and haemostasis : JTH. 2020 July;18(7):1586-1597. PubMed PMID: 32196903; PubMed Central PMCID: PMC7786582; DOI: 10.1111/jth.14804.

Lee JW, Beatty GL. Hepatocytes prepare the soil for liver metastasis. Molecular & cellular oncology. 2019;6(5):e1632686. PubMed PMID: 31528701; PubMed Central PMCID: PMC6736154; DOI: 10.1080/23723556.2019.1632686.

Lee JW, Beatty GL. Inflammatory networks cultivate cancer cell metastasis to the liver. Cell cycle (Georgetown, Tex.). 2020 March;19(6):642-651. PubMed PMID: 32053029; PubMed Central PMCID: PMC7145328; DOI: 10.1080/15384101.2020.1728013.

Thomas SK, Lee J, Beatty GL. Paracrine and cell autonomous signalling in pancreatic cancer progression and metastasis. EBioMedicine. 2020 March;53:102662. PubMed PMID: 32139180; PubMed Central PMCID: PMC7118576; DOI: 10.1016/j.ebiom.2020.102662.

Serrano-Lopez J, Hegde S, Kumar S, Serrano J, Fang J, Wellendorf AM, Roche PA, Rangel Y, Carrington LJ, Geiger H, Grimes HL, Luther S, Maillard I, Sanchez-Garcia J, Starczynowski DT, Cancelas JA. Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics. eLife. 2021 April 8;10. PubMed PMID: 33830019; PubMed Central PMCID: PMC8137144; DOI: 10.7554/eLife.66190.

Klichinsky M, Ruella M, Shestova O, Lu XM, Best A, Zeeman M, Schmierer M, Gabrusiewicz K, Anderson NR, Petty NE, Cummins KD, Shen F, Shan X, Veliz K, Blouch K, Yashiro-Ohtani Y, Kenderian SS, Kim MY, O'Connor RS, Wallace SR, Kozlowski MS, Marchione DM, Shestov M, Garcia BA, June CH, Gill S. Human chimeric antigen receptor macrophages for cancer immunotherapy. Nature biotechnology. 2020 August;38(8):947-953. PubMed PMID: 32361713; PubMed Central PMCID: PMC7883632; DOI: 10.1038/s41587-020-0462-y.

Chen GM, Chen C, Das RK, Gao P, Chen CH, Bandyopadhyay S, Ding YY, Uzun Y, Yu W, Zhu Q, Myers RM, Grupp SA, Barrett DM, Tan K. Integrative Bulk and Single-Cell Profiling of Premanufacture T-cell Populations Reveals Factors Mediating Long-Term Persistence of CAR T-cell Therapy. Cancer discovery. 2021 September;11(9):2186-2199. PubMed PMID: 33820778; PubMed Central PMCID: PMC8419030; DOI: 10.1158/2159-8290.CD-20-1677.

Reiss KA, Wattenberg MM, Damjanov N, Prechtel Dunphy E, Jacobs-Small M, Lubas MJ, Robinson J, Dicicco L, Garcia-Marcano L, Giannone MA, Karasic TB, Furth EE, Carpenter EL, Wojcieszynski AP, Vonderheide RH, Beatty GL, Ben-Josef E. A Pilot Study of Galunisertib plus Stereotactic Body Radiotherapy in Patients with Advanced Hepatocellular Carcinoma. Molecular cancer therapeutics. 2021 February;20(2):389-397. PubMed PMID: 33268571; PubMed Central PMCID: PMC7867621; DOI: 10.1158/1535-7163.MCT-20-0632.

Poventud-Fuentes I, Kwon KW, Seo J, Tomaiuolo M, Stalker TJ, Brass LF, Huh D. A Human Vascular Injury-on-a-Chip Model of Hemostasis. Small (Weinheim an der Bergstrasse, Germany). 2021 April;17(15):e2004889. PubMed PMID: 33150735; PubMed Central PMCID: PMC8049960; DOI: 10.1002/smll.202004889.

Lin JH, Huffman AP, Wattenberg MM, Walter DM, Carpenter EL, Feldser DM, Beatty GL, Furth EE, Vonderheide RH. Type 1 conventional dendritic cells are systemically dysregulated early in pancreatic carcinogenesis. The Journal of experimental medicine. 2020 August 3;217(8). PubMed PMID: 32453421; PubMed Central PMCID: PMC7398166; DOI: 10.1084/jem.20190673.

Bellissimo DC, Chen CH, Zhu Q, Bagga S, Lee CT, He B, Wertheim GB, Jordan M, Tan K, Worthen GS, Gilliland DG, Speck NA. Runx1 negatively regulates inflammatory cytokine production by neutrophils in response to Toll-like receptor signaling. Blood advances. 2020 March 24;4(6):1145-1158. PubMed PMID: 32208490; PubMed Central PMCID: PMC7094023; DOI: 10.1182/bloodadvances.2019000785.

Mack EA, Stein SJ, Rome KS, Xu L, Wertheim GB, Melo RCN, Pear WS. Trib1 regulates eosinophil lineage commitment and identity by restraining the neutrophil program. Blood. 2019 May 30;133(22):2413-2426. PubMed PMID: 30917956; PubMed Central PMCID: PMC6543518; DOI: 10.1182/blood.2018872218.

Behera V, Stonestrom AJ, Hamagami N, Hsiung CC, Keller CA, Giardine B, Sidoli S, Yuan ZF, Bhanu NV, Werner MT, Wang H, Garcia BA, Hardison RC, Blobel GA. Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription. Cell reports. 2019 April 9;27(2):400-415.e5. PubMed PMID: 30970245; PubMed Central PMCID: PMC6664437; DOI: 10.1016/j.celrep.2019.03.057.