Open to Enrollment

HIV Comorbidities (CMV, Hepatitis B, Weight Gain)

A5394  Safety, Tolerability, and Impact of Oral TLR8 Agonist Selgantolimod on HBsAg in Participants with Both Chronic Hepatitis B and HIV.  Jason Kirschner

HIV Cure Related

A5374  A Phase I/IIa Randomized, Placebo-Controlled Trial of Conserved-Mosaic T-cell Vaccine in a Regimen with Vesatolimod and Broadly Neutralizing Antibodies in Adults Initiated on Suppressive Antiretroviral Therapy during Acute HIV-1.  Safa Elbakhit

A5388  A Double-Blind, Randomized, Placebo-Controlled Clinical Trial of Combination HIV-Specific Broadly Neutralizing Monoclonal Antibodies Combined with ART Initiation during Acute HIV Infection to Induce HIV Remission.  Tina Nguyen

HIV New Therapies (long-acting medications, switch to new treatment)

Gilead 6143  Phase 1b Randomized, Blinded, Placebo-Controlled, Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of GS-8588 in People with HIV-1 who are Virologically Suppressed on Antiretroviral Therapy. Jason Kirschner

CROWN  A Phase 3b, Open Label, Randomized, Standard-of-Care Control Arm, Multicenter, Superiority Study Evaluating the Efficacy, Safety and Tolerability of Injectable CAB LA + RPV LA in Viremic Participants living with HIV-1.  Tina Nguyen

HIV Women's Health (pregnancy, breastfeeding)

GS-985-6381  Economic Incentive to Increase Provider Reporting to the Antiretroviral Pregnancy Registry.  Erin Logue-Chamberlain

Vaccines

BNT163-01  Phase 1, Randomized, Observer-blinded, Placebo-controlled, 2-part, Dose Escalation and Expended Safety Evaluation Trial to Evaluate the Safety, Tolerability, and Immunogenicity of an Investigational Prophylactic Vaccine for the Prevention of Genital Lesions Caused by HSV-2 and Potentially HSV-1.  Chungdhak Tsang

A5422  Safety and Immunogenicity of Stabilized CH505 TF chTrimer Vaccination in Adults Living with HIV-1 on Suppressive Antiretroviral Therapy. Safa Elbakhit