Benjamin Prosser

Associate Professor

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726 Clinical Research Building

415 Curie Boulevard

Philadelphia, PA 19104

Research Description

The Prosser Lab - developing new therapies for the heart and brain.
(Simple, right?)  

Our lab interrogates the forces of the heart – the mechanisms that control how a heart cell generates force, and how force itself feeds back to regulate cell function and form. We leverage cellular biophysics and engineering, super-resolution imaging and cardiology to tackle the fundamental challenges of the mechanobiology of the heart. Our goal is to provide transformative insight into how the heart beats, and to inform new therapies for the treatment of heart disease.  

The diagnosis of Dr. Prosser's daughter with STXBP1 encephalopathy also spurred the generation of a new therapeutic arm in the lab for neurological applications. We are developing novel, antisense oligonucleotide based therapies for the treatment of inherited neurodevelopmental disorders, such as those caused by mutations in STXBP1. 

Diversity & Inclusion Initiatives

  • Mentor and Lecturer, Penn SUIP and PREP programs
  • Host of Workshop in Cell Biology for STEM undergrads from underrepresented communities
  • Member, Admissions committee for Cell Biology, Physiology and Metabolism (CPM) graduate group, which facilitates recruitment of diversity trainees. 

Degrees & Education

BS, Wake Forest University, 2005

PhD, University of Maryland School of Medicine, 2009

Honors & Awards

2011 Outstanding Postdoctoral Scholar Award

2017 Linda Pechenik Montague Investigator Award

2017 Outstanding Early Career Investigator Award, American Heart Association (AHA)

2018 Outstanding Alumnus Award, University of Maryland School of Medicine

2021 Lead Coordinator, Leducq Transatlantic Network of Excellence

Other Perelman School of Medicine Affiliations

Pennsylvania Muscle Institute

Cardiovascular Institute

Professional Affiliations

Biophysical Society

Cardiac Muscle Society

American Heart Association

STXBP1 Foundation Scientific Advisory Board

Recent Publications
March 11, 2021
Microtubules orchestrate local translation to enable cardiac growth
Benjamin Prosser, Ph.D.
Scarborough EA, Uchida K, Vogel M, Erlitzki N, Iyer M, Phyo SA, Bogush A, Kehat I, Prosser BL. - DOI: 10.1038/s41467-021-21685-4
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January 26, 2021
Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes. Cell Stem Cell
Benjamin Prosser, Ph.D.
Shah PP, Lv W, Rhoades JH, Poleshko A, Abbey D, Caporizzo MA, Linares-Saldana R, Heffler JG, Sayed N, Thomas D, Wang Q, Stanton LJ, Bedi K, Morley MP, Cappola TP, Owens AT, Margulies KB, Frank DB, Wu JC, Rader DJ, Yang W, Prosser BL, Musunuru K, Jain R. - DOI: 10.1016/j.stem.2020.12.016
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January 14, 2021
Tubulin Detyrosination: An Emerging Therapeutic Target in Hypertrophic Cardiomyopathy
Benjamin Prosser, Ph.D.
Margulies KB, Prosser BL - DOI: 10.1161/CIRCHEARTFAILURE.120.008006
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ALL Publications Arrow Icon