Congratulations to our very own Katya Grishchuk, PhD for her promotion from associate professor to professor! We would like to thank Dr. Grishchuk for her outstanding contributions to our department and the scientific community as a whole. Please join us in congratulating Katya on this well-deserved accomplishment.

Congratulations to Erika Holzbaur for securing a $1,000,000 donation to establish a Huntington’s Disease Research Fund. The donation will be used to support basic Huntington’s research by three postdoctoral fellows for three years in key University laboratories. The fund will also be used to provide resources for program coordination and laboratory collaboration related to Huntington’s disease. It's absolutely fabulous that such a donation has been elicited and how it is being directed to our young scientists. Both speak to the imagination of the donor and the creativity of the recipient. Pease join me in congratulating Erika on this impressive achievement.

I am pleased to join with Dr. Kevin Foskett, Chair of the Department of Physiology, to announce the appointment of Dr. Erika L. F. Holzbaur as the new director of the Pennsylvania Muscle Institute (PMI), effective May 1, 2024. Dr. Holzbaur is a world-renowned scientist with a research program focused on the cytoskeleton and dynamics of organelle transport in neurons. As former program chair of the Cell Biology, Physiology, and Metabolism graduate program, and former president of the American Society for Cell Biology, Dr. Holzbaur brings a proven track record of leading and fostering strong collaboration within scientific communities. Her skills and collaborative spirit make her a perfect fit to lead the PMI in its mission. As PMI director, Dr. Holzbaur will lead an interdisciplinary group of research investigators from PSOM and across the Penn campus. Established more than half a century ago, the mission of the PMI is to discover the mechanisms of muscle function, muscle disease and motile biological systems; develop state-of-the art technologies for the study of muscle and motile systems; and provide education and training in muscle biology and motility to scientists, physicians, and students. Research is conducted by its more than 50 laboratories using biophysics, biochemistry, genetics, physiology and ultrastructure to understand cell migration and intracellular transport, molecular motors, cell division, muscle contraction and development, muscle pathologies and therapies targeted to muscle disease. For more information about Dr. Holzbaur's impressive background, please see her bio below. Having directed the PMI for the last 14 years, collaborating with exceptional scientists like Dr. Holzbaur has been a highlight of my career. I have every confidence that she will further elevate the rich scientific and mentoring environment for which the PMI is known. Please join in thanking Dr. Holzbaur for serving in this important leadership role. Thank you, Mike E. Michael Ostap, PhD Professor of Physiology Interim Senior Vice Dean and Chief Scientific Officer, Perelman School of Medicine at the University of Pennsylvania

In 2002, Sally Zigmond and other UPenn/PMI scientists made the seminal discovery of formin’s ability to nucleate and elongate actin filaments (Science; DOI: 10.1126/science.1072309). Utilizing UPenn’s cryo-EM facility, Nick Palmer and Kyle Barrie, students in the Dominguez lab, have just published in Nature (https://rdcu.be/dJ8mW) the cryo-EM structures of INF2 and Dia1 that now provide a step-by-step visualization of the mechanisms of actin filament severing and elongation, bringing this story full-circle here at Penn! The implications of this study are profound since formin dysfunction is linked to pathologies, including cardiomyopathies, cancers, and neurological disorders. Mutations in the two formins studied in their paper, INF2 and Dia1, produce focal segmental glomerulosclerosis and Charcot-Marie-Tooth neuropathy (INF2), and deafness (Dia1). Please join me in congratulating the Dominguez lab on this accomplishment!