The Department of Physiology

Welcome to Penn Physiology! We invite you to spend time on our site and learn more about our vibrant department. We welcome your interest and invite you to spend time on our site. Visit the "Faculty” page to learn about the depth and breadth of our research interests; search the “About" page for department information, administrative staff contacts, and discover some history of the department in the process. Be sure to check the “Events” page frequently to stay current on our upcoming seminars and events.

See the latest
Events

Oct 21, 2021 @ 9:30AM

Ion channel journal club

https://bluejeans.com/306648139

Speaker: Andy Harris, Ph.D.

Oct 21, 2021 @ 12:00PM

Cell biology in neuroscience journal club

Clinical Research Building Rm. 702 - 415 Curie Boulevard; Philadelphia PA, 19104 or bluejeans.com/126430267

Article: “Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C.” Roney, Joseph C., et al. (2021). https://doi.org/10.1016/j.devcel.2021.03.032 - Speaker: Sydney Cason

Oct 21, 2021 @ 4:00PM

Physiology faculty recruitment seminar: natali chanaday ricagni, phd

Clinical Research Building, Austrian Auditorium, 415 Curie Boulevard Philadelphia, PA 19104 - https://pennmedicine.zoom.us/j/96511874414?pwd=Um12K3B1VTkxbStTTGUxZGpBSWtudz09

Title: Novel pathways regulating spontaneous neurotransmission

OUR MISSION

Physiology is the study of how living systems function. Physiologists seek to describe biological processes in physical and chemical terms. Accordingly, physiologists can be trained in diverse, which enable them to bring unique insights and technical approaches to study living systems from the sub-cellular level to the whole organism. For example, faculty in our Department have been trained in chemistry, medicine, zoology, physics, biochemistry, mathematics, biophysics, cell and developmental biology, neurobiology, and, believe it or not, physiology. Physiologists may be interested in the molecular function of individual molecules such as enzymes, membrane transporters, or molecular motors, or in how these molecules interact within a network to generate higher-level biological activities.

Penn Physiology faculty have particular strengths in the molecular biophysics of membrane transport proteins and biological motors, as well as in the cell physiology and integrative biology of transport, motility, signaling and metabolism. We employ a wide range of experimental techniques in the fields of cell and molecular biology, chemistry, physics, engineering, genetics, genomics, and bioinformatics. It may not be an overstatement to suggest that Physiology enables insights from biophysics, biochemistry, molecular biology, cell biology, genetics, and pharmacology to be described in an integrated manner that can be applied to human medicine. Much of clinical medicine relies on understanding molecular, cellular and organ-system physiology.

Our Research
The multi-disciplinary approaches employed by our faculty encourage scientific collaborations with scientists in other departments throughout the Perelman School of Medicine and beyond.
The Physiology Department is comprised of faculty whose research ranges from studies of single molecule behaviors to integrative physiology. In addition, many of our faculty have formal ties to other entities at Penn, including The Pennsylvania Muscle Institute, The Center for Orphan Disease Research and Therapy, The Institute for Environmental Medicine, the Abramson Cancer Center, the Institute for Diabetes, Obesity and Metabolism and the Center for Nanotechnology, among others. Our faculty are also strongly committed to medical and graduate student education, with leadership roles in courses, seminars and journal clubs in Physiology, Biochemistry, Molecular Biophysics, Cell Biology, and many more.

The Lakadamyali Lab

Super-resolution image of microtubules and tau aggregates (α-tubulin in magenta P301L tau in cyan) (in cells that express GFP-P301L tau and contain tau aggregates) Credit: Melina Gyparaki

Carol Deutsch, PhD

The Deutsch laboratory is the only one studying the early stages of folding of Kv proteins and one of a few laboratories studying the functional biophysical properties of the exit tunnel.

Benjamin Prosser, PhD

Ben is an emerging leader in new, exciting aspects of the molecular physiology of cardiomyocyte function and signaling. The photo featured here is credited to his lab.

Zhe Lu, MD, PhD

Zhe Lu, MD, PhD is an internationally recognized leader in studies of potassium channel ion permeation.

From Our Chair
J. Kevin Foskett, Ph.D.
Welcome to the Department of Physiology in the Perelman School of Medicine at the University of Pennsylvania. Our Department is devoted to research, training, and education and strives to push the boundaries of scientific discovery and academic development. The Department’s internationally recognized faculty, in conjunction with post-doctoral fellows, graduate students, and staff, use innovative tools to uncover physical and chemical mechanisms of biological processes. Our frontiers span the molecular to organ level to determine how the human body functions in health and disease. We welcome your interest and invite you to spend time on our site.

Our Faculty

Get to know our multi-disciplinary Faculty members.