The Department of Physiology

Welcome to Penn Physiology! We invite you to spend time on our site and learn more about our vibrant department.

Cell Biology, Physiology, and Metabolism Program

Our research includes Cytoskeleton, Motor Proteins and Cell & Organellar Motility,Integrative Physiology & Metabolism,Signal Transduction

Welcome to

The Department of Physiology

The Department of Physiology at the University of Pennsylvania traces its origins to 1780, when Caspar Wistar first proposed a course in the “Institutes of Medicine,” making it the first basic medical science department in the United States. Rooted in the traditions of the University of Edinburgh, Penn Physiology has evolved over centuries into a hub of pioneering research and education. Today, the department is recognized for its strengths in molecular biophysics, membrane transport, muscle physiology, and integrative biology, with faculty employing cutting-edge approaches from molecular biology, genetics, engineering, and bioinformatics. By bridging disciplines from biophysics to pharmacology, Penn Physiology continues to play a central role in advancing biomedical knowledge and training the next generation of physician-scientists, with direct relevance to human health and clinical medicine.

Events

Seminar: At the Leading Edge

Dec 1, 2025 @ 03:00pm
Fall 2025 Seminars At the Leading Edge Seminar
Fall 2025 Seminars At the Leading Edge Seminar

Ion Channel Journal Club

Dec 4, 2025 @ 09:30am
Fall 2025 Ion Channel Journal Club Journal Clubs
Fall 2025 Ion Channel Journal Club Journal Clubs

Ion Channel Journal Club

Dec 18, 2025 @ 09:30am
Fall 2025 Ion Channel Journal Club Journal Clubs
Fall 2025 Ion Channel Journal Club Journal Clubs

Ion Channel Journal Club

Jan 8, 2026 @ 09:30am
Ion Channel Journal Club Journal Clubs Spring 2026
Ion Channel Journal Club Journal Clubs Spring 2026

Ion Channel Journal Club

Jan 22, 2026 @ 09:30am
Journal Clubs Spring 2026 Ion Channel Journal Club
Journal Clubs Spring 2026 Ion Channel Journal Club
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News

Announcing the appointment of Zoltan Arany, MD, PhD, as Chair of the Department of Physiology

We are pleased to announce the appointment of Zoltan (Zolt) Arany, MD, PhD, as Chair of the Department of Physiology in the Perelman School of Medicine at the University of Pennsylvania,

2025 index

Congratulations to Professor Grishchuk!

Congratulations to our very own Katya Grishchuk, PhD for her promotion from associate professor to professor! We would like to thank Dr. Grishchuk for her outstanding contributions to our department and the scientific community as a whole.

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Congratulations to Erika Holzbaur!

Congratulations to Erika Holzbaur for securing a $1,000,000 donation to establish a Huntington’s Disease Research Fund. The donation will be used to support basic Huntington’s research by three postdoctoral fellows for three years in key University laboratories.

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Announcing the appointment of Erika L. F. Holzbaur, PhD, as the new Director of the Pennsylvania Muscle Institute

I am pleased to join with Dr. Kevin Foskett, Chair of the Department of Physiology, to announce the appointment of Dr. Erika L. F. Holzbaur as the new director of the Pennsylvania Muscle Institute (PMI),

2024

Congratulations to the Dominguez Lab!

In 2002, Sally Zigmond and other UPenn/PMI scientists made the seminal discovery of formin’s ability to nucleate and elongate actin filaments (Science; DOI: 10.1126/science.1072309). Utilizing UPenn’s cryo-EM facility, Nick Palmer and Kyle Barrie,

2024
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Our Mission

Physiology is the study of how living systems function. Physiologists seek to describe biological processes in physical and chemical terms. Accordingly, physiologists can be trained in diverse, which enable them to bring unique insights and technical approaches to study living systems from the sub-cellular level to the whole organism. For example, faculty in our Department have been trained in chemistry, medicine, zoology, physics, biochemistry, mathematics, biophysics, cell and developmental biology, neurobiology, and, believe it or not, physiology. Physiologists may be interested in the molecular function of individual molecules such as enzymes, membrane transporters, or molecular motors, or in how these molecules interact within a network to generate higher-level biological activities.

Penn Physiology faculty have particular strengths in the molecular biophysics of membrane transport proteins and biological motors, as well as in the cell physiology and integrative biology of transport, motility, signaling and metabolism. We employ a wide range of experimental techniques in the fields of cell and molecular biology, chemistry, physics, engineering, genetics, genomics, and bioinformatics. It may not be an overstatement to suggest that Physiology enables insights from biophysics, biochemistry, molecular biology, cell biology, genetics, and pharmacology to be described in an integrated manner that can be applied to human medicine. Much of clinical medicine relies on understanding molecular, cellular and organ-system physiology.

Our Faculty

Get to know our multi-disciplinary Faculty members.

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