Research Description

Our lab studies several aspects of cell mechanics. In one project, we produce soft materials, usually hydrogels, to which cell adhesion proteins are linked to study how the stiffness of surfaces alters cell structure, function, and growth. Endothelial cells, fibroblasts, neurons and astrocytes each show unique dependence on both elastic and viscous properties of the substrate, and we seek to understand how they sense and respond to this mechanical cue. In related work we measure the structure and mechanics of cytoskeletal polymers using a variety of imaging, scattering, and rheologic methods. Further studies examine how changes in cell membrane structure mediated by inositol phospholipids lead to production of signals that remodel the cytoskeleton.

Diversity & Inclusion Initiatives

• Sponsor for undergraduate students and high school teachers in REU and RET programs within NSF-supported CEMB and MRSEC programs at Penn.
• Lab composition within the last 10 years:  17% URM; 56% female