Shampa Chatterjee

Associate Professor

215-898-9101
shampac@pennmedicine.upenn.edu

1 John Morgan

3620 Hamilton Walk

Philadelphia, PA 19104

 

Research Description

All projects in the lab are centered on understanding the inflammation-immune response to stimuli ranging from mechanical and chemical to pathogenic. In this direction, our interest has been on the vascular system which serves as the converging site for inflammation; indeed, the endothelium that lines the vascular system is where immune cells “home in to adhere” and finally extravasate into tissue. To understand the signaling cues that drive recruitment and adherence, my lab is focused on understanding the endothelial machinery with mechanotransduction (sensing alteration in blood flow) and chemotransduction (sensing chemical cues such as cigarette smoke, oxidants, endotoxins etc.) that upon activation initiates the immune response.  

A major driver of amplification of inflammation is the NLRP3 inflammasome and we are currently engaged in studying its assembly using conventional in vitro and 3-D models of lungs and gingival tissue. Our goal is to block the redox signals that drive NLRP3 priming and activation to modulate and resolve the progression of inflammation in models of lung endothelium and in periodontal tissue.

The intersection of inflammation with disrupted circadian rhythm is also of interest to us. Alteration of circadian rhythm affects reactive oxygen species production and initiates redox signals in diverse cell types ranging from endothelium to osteoblasts and osteoclasts. In collaboration with researchers in sleep medicine, we are engaged in identifying the signaling pathways that are initiated upon sleep deprivation and that in turn activate signaling cascades associated with inflammation.

Diversity & Inclusion Initiatives

  • The lab consists of a racially and ethnically diverse group of individuals
  • It is a safe space to have a discussion and dialogue on diversity, racial and gender equity, and inclusion
  • We actively promote diversity and inclusion and have hosted summer programs for minority groups who at present are underrepresented in STEM disciplines

Degrees & Education

PhD (Biochemistry) Indian Institute of Technology, Bombay, India, 1997

Fellow ITP, GBF, Gelleschaft fuer Biotechnologische Forschung, Braunschweig, Germany, 1996-1997

Fellow, Institut Fuer Medizinische Neurobiologie Otto von Guericke Universitaet Magdeburg, Germany, 1997-1999

Postdoctoral Fellow, Institute for Environmental Medicine, University of Pennsylvania Perelman School of Medicine, 1999-2002

Research Associate, Institute for Environmental Medicine, University of Pennsylvania Perelman School of Medicine, 2002-2006

Honors & Awards

2015 Hermann Rahn Award

2014 APS select for distinction in scholarship in Am J Physiol Lung Cell Mol Physiol (306 :L260-8, 2014)

2002 Julius Comroe, Jr. Award, American Physiological Society

2000 Caroline tum Suden Professional Excellence Award, American Physiology Society

1997 UNESCO International Training Program Fellowship, Braunschweig, Germany

1991 CSIR Research Fellowship Award, Ministry of Human Resources, New Delhi, India

1985 National Talent Search Scholarship, National Council Education, Research & Training, New Delhi, Govt. of India

Other Perelman School of Medicine Affiliations

Radiology

Chronobiology and Sleep Institute

Professional Affiliations

Member of American Physiological Society

Radiation Research Society

American Society for Bone and Mineral Research

Recent Publications
February 10, 2022
Pulmonary vascular inflammation with fatal coronavirus disease 2019 (COVID-19): possible role for the NLRP3 inflammasome
Shampa Chatterjee, Ph.D.
Paul, O., Tao, J.Q., West, E., Litzky, L., Feldman, M., Montone, K., Rajapakse, C., Bermudez, C., & Chatterjee, S. - https://doi.org/10.1186/s12931-022-01944-8
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August 15, 2021
Utility of FDG PET/CT in assessing bowel inflammation
Shampa Chatterjee, Ph.D.
Gelston D, Brosler SC, Vazquez J, Sorci O, Griffith AH, Chatterjee S, Buchner A, Høilund-Carlsen PF, Alavi A, Rajapakse CS. Am J Nucl Med Mol Imaging. 2021 Aug 15;11(4):271-279. PMID: 34513280; PMCID: PMC8414397.
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August 6, 2021
Vascular Health: The Endothelial Perspective in Regulation of Inflammation and Injury
Shampa Chatterjee, Ph.D.
Chatterjee S, Lacchini S, Jungraithmayr W, Wehrli FW. Front Physiol. 2021 Aug 6;12:732234. doi: 10.3389/fphys.2021.732234. PMID: 34426732; PMCID: PMC8379013.
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October 24, 2021
Inhibition of Peroxiredoxin 6 PLA2 Activity Decreases Oxidative Stress and the Severity of Acute Lung Injury in the Mouse Cecal Ligation and Puncture Model
Shampa Chatterjee, Ph.D.
Fisher AB, Dodia C, Tao JQ, Feinstein SI, Chatterjee S. Antioxidants (Basel). 2021 Oct 24;10(11):1676. doi: 10.3390/antiox10111676. PMID: 34829547; PMCID: PMC8615065.
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June 3, 2020
Severe Impairment of Microcirculatory Perfused Vessel Density Is Associated With Postoperative Lactate and Acute Organ Injury After Cardiac Surgery
Shampa Chatterjee, Ph.D.
Greenwood JC, Jang DH, Hallisey SD, Gutsche JT, Horak J, Acker MA, Bermudez CA, Zhou VL, Chatterjee S, Shofer FS, Kilbaugh TJ, Augoustides JGT, Meyer NJ, Bakker J, Abella BS - DOI:https://doi.org/10.1053/j.jvca.2020.04.045
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March 19, 2021
Vascular Inflammation in Lungs of Patients with Fatal Coronavirus Disease 2019 (COVID-19) Infection: Possible role for the NLRP3 inflammasome
Shampa Chatterjee, Ph.D.
Paul O, Tao J, Litzky L, Feldman M, Montone K, Rajapakse C, Bermudez C, Chatterjee, S - DOI: https://doi.org/10.1101/2021.03.19.21253815
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November 11, 2020
Pulmonary pyruvate metabolism as an index of inflammation and injury in a rat model of acute respiratory distress syndrome
Shampa Chatterjee, Ph.D.
Pourfathi M, Xin Y, Rosalino M, Cereda M, Kadlecek S, Duncan I, Profka H, Hamedani H, Siddiqui S, Ruppert K, Chatterjee S, Rizi RR - DOI: 10.1002/nbm.4380
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