Tejvir S. Khurana

Professor

215-898-4116

tsk@pennmedicine.upenn.edu

752B Clinical Research Building

415 Curie Boulevard

Philadelphia, PA 19104

Research Description

We study molecular mechanisms underlying muscle specializations and patho-physiology of muscle diseases. Topics include developmental changes of muscle as a whole that lead to the formation of unique skeletal muscle group such as the extraocular muscle (EOM), control of muscle size by growth / developmental factors, as well as formation of synapses or neuromuscular junctions). This research is also interesting from a disease perspective since some of these molecules / pathways (e.g. myostatin, utrophin) offer therapeutic strategies for muscular dystrophy.

Degrees & Education

MBBS, Delhi University, 1985

PhD, Harvard University, 1992

Honors & Awards

National Talent Search Scholarship, National Council Education, Research & Training, India

Research Fellowship, Muscular Dystrophy Association, USA

Clinical Investigator Development Award, National Institutes of Health, USA

Presidential Early Career Award for Scientists and Engineers

Lindback Award for Distinguished Teaching

Other Perelman School of Medicine Affiliations

Mahoney Institute of Neurological Sciences

Pennsylvania Muscle Institute (PMI)

Professional Affiliations

American Physiological Society

Association for Research in Vision and Ophthalmology

American Society for Human Genetics

World Muscle Society

Recent Publications

November 9, 2021

AKT controls protein synthesis and oxidative metabolism via combined mTORC1 and FOXO1 signaling to govern muscle physiology

Tejvir S. Khurana

Natasha Jaiswal, Matthew Gavin, Emanuele Loro, Jaimarie Sostre-Colón, Paul A. Roberson, Kahealani Uehara, Nicole Rivera-Fuentes, Michael Neinast, Zoltan Arany, Scot R. Kimball, Tejvir S. Khurana, Paul M. Titchenell https://doi.org/10.1002/jcsm.12846

Article

December 9, 2020

PMO-based let-7c site blocking oligonucleotide (SBO) mediated utrophin upregulation in mdx mice, a therapeutic approach for Duchenne muscular dystrophy (DMD)

Tejvir S. Khurana

Sengupta K, Loro E, Khurana TS - DOI: 10.1038/s41598-020-76338-1

Article

December 4, 2020

Genome Editing-Mediated Utrophin Upregulation in Duchenne Muscular Dystrophy Stem Cells

Tejvir S. Khurana

Sengupta K, Mishra MK, Loro E, Spencer MJ, Pyle AD, Khurana TS - DOI: 10.1016/j.omtn.2020.08.031

Article

May 15, 2020

Tibetan PHD2, an allele with loss-of-function properties

Tejvir S. Khurana

Song D, Navalsky BE, Guan W, Ingersoll C, Wang T, Loro E, Eeles L, MatchettKB, Percy MJ, Walsby-Tickle J, McCullagh JSO, Medina RJ, Khurana TS, Bigham AW, Lappin TR, Lee FS - DOI: 10.1073/pnas.1920546117

Article

ALL Publications