Toshinori Hoshi



605B Clinical Research Building

415 Curie Boulevard

Philadelphia, PA 19104

Research Description

Gating, opening, and closing processes, of ion channels are being investigated at multiple levels of biological organizations.  At the atomic and molecular levels, the nature of ion conduction gate and its modulation of large-conductance calcium- and voltage-gated (Slo1 BK) potassium channels are studied computationally and experimentally investigated using molecular dynamics simulations and electrophysiological methods in combination with ion channel kinetics simulations.  In addition, modulation of TMEM16A calcium-dependent chloride channels is studied.  At the cellular and organ level, electrical properties of human, rat and mouse pancreatic beta cells are studied. 

Degrees & Education

PhD, Yale University, 1985

BA, University of New Hampshire, 1981

Honors & Awards

Mercator Fellow at Die Deutsche Forschungsgemeinschaft (German Research Foundation)

Paul F. Cranefield Award, Society of General Physiologists

McKnight Scholar in Neurosciences

Klingenstein Fellowship Award in the Neurosciences

President, Society of General Physiologists (2011-2013)

Other Perelman School of Medicine Affiliations

Mahoney Institute of Neurological Sciences

Neuroscience Graduate Group

Institute of Aging

Professional Affiliations

Society of General Physiologists

Society for Neuroscience

Biophysical Society

American Association for the Advancement of Science

Recent Publications
August 27, 2022
Intracellular hemin is a potent inhibitor of the voltage-gated potassium channel
Toshinori Hoshi, Ph.D.
Sahoo N, Yang K, Coburger I, Bernert A, Swain SM, Gessner G, Kappl R, Kühl T, Imhof D, Hoshi T, Schönherr R, Heinemann SH. Kv10.1. Sci Rep. 2022 Aug 27;12(1):14645. doi: 10.1038/s41598-022-18975-2. PubMed PMID: 36030326; PubMed Central PMCID: PMC9420133.
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February 25, 2022
Blocking Kir6.2 channels with SpTx1 potentiates glucose-stimulated insulin secretion from murine pancreatic β cells and lowers blood glucose in diabetic mice
Toshinori Hoshi, Ph.D.
Ramu Y, Yamakaze J, Zhou Y, Hoshi T, Lu Z DOI: 10.7554/eLife.77026
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February 22, 2021
Regulation of large-conductance Ca2+- and voltage-gated K+ channels by electrostatic interactions with auxiliary β subunits
Toshinori Hoshi, Ph.D.
Tian Y, Heinemann SH, Hoshi T - DOI: 10.1101/2021.02.22.432338.
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March 4, 2021
Decreased KATP channel activity contributes to the low glucose threshold for insulin secretion in the early postnatal period
Toshinori Hoshi, Ph.D.
Yang J, Hammoud B, Li C, Ridler A, Yau D, Kim J, Won K-J, Stanley CA, Hoshi T, Stanescu DE - DOI: 10.1101/2021.03.04.433947
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May 10, 2020
Impact of intracellular hemin on N-type inactivation of voltage-gated K+ channels
Toshinori Hoshi, Ph.D.
Coburger I, Yang K, Bernert A, Wiesel E, Sahoo N, Swain SM, Hoshi T, Schonherr R, Heinemann SH - DOI: 10.1007/s00424-020-02386-1 - PMID: 32388729
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