Laboratory of Rare Lung Diseases

Elena A. Goncharov, Ph.D.

Elena A Goncharov, PhDAssistant Professor of Medicine 
University of Pennsylvania Medical Center
Pulmonary, Allergy & Critical Care Division
Translational Research Laboratories (TRL)
125 South 31st Street, TRL Suite 1200
Philadelphia, PA 19104-3413

(215) 746-3593
 (215) 746-1224
goncharo@mail.med.upenn.edu

Education: 
PhD, Cardiology Research Center, Russian Academy of Sciences, Moscow, Russia

Postdoctoral Fellowship: 
Department of Medicine at the University of Pennsylvania, Philadelphia, PA

Dr. Goncharova joined Airways Biology Initiative (ABI) in 2001 as a postdoctoral fellow. Her research interests are in the cellular and molecular mechanisms of smooth muscle cell remodeling, growth and motility as it relates to pulmonary arterial hypertension (PAH), pulmonary lymphangioleiomyomatosis (LAM), asthma and COPD. The main focus of Dr. Goncharova's current research is defining the role ofmammalian target of rapamycin (mTOR) and specific roles of mTOR complex 1 (mTORC1) and mTORC2 in vascular smooth muscle cell proliferation and pulmonary vascular remodeling in PAH. 

Selected publications

  1. Goncharova EA. mTOR and vascular remodeling in lung diseases: current challenges and therapeutic prospects. FASEB J. 2013 Jan 25. [Epub ahead of print]
  2. Goncharova EA, Khavin IS, Goncharov DA, Krymskaya VP. Differential effects of formoterol on thrombin- and PDGF-induced proliferation of human pulmonary arterial vascular smooth muscle cells. Respir Res. 2012 Nov 27;13(1):109. [Epub ahead of print]
  3. Medvetz DA, Khabibullin D, Hariharan V, Ongusaha PP, Goncharova EA, Schlechter T, Darling TN, Hofmann I, Krymskaya VP, Liao JK, Huang H, Henske EP. Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion. PLoS One. 2012;7(11):e47842. Epub 2012 Nov 6.
  4. Goncharova EA, Goncharov DA, Fehrenbach M, Khavin I, Ducka B, Hino O, Colby TV, Merrilees MJ, Haczku A, Albelda SM, Krymskaya VP. Prevention of Alveolar Destruction and Airspace Enlargement in a Mouse Model of Pulmonary Lymphangioleiomyomatosis (LAM). Sci Transl Med. 2012 Oct 3;4(154):154ra134.
  5. Koziol-White CJ, Goncharova EA, Cao G, Johnson M, Krymskaya VP, Panettieri RA Jr. DHEA-S inhibits human neutrophil and human airway smooth muscle migration. Biochim Biophys Acta. 2012 Jul 3. [Epub ahead of print]
  6. Goncharova EA, Goncharov DA, Zhao H, Penn RB, Krymskaya VP, Panettieri Jr RA. {beta}2AR Agonists Modulate Human Airway Smooth Muscle Cell Migration Via VASP. Am J Respir Cell Mol Biol. 2011 Jul 28
  7. Goncharova EA, Goncharov DA, Li H, Pimtong W, Lu S, Khavin I, Krymskaya VP: mTORC2 is Required for Proliferation and Survival of TSC2-Null Cells. Molecular and Cellular Biology 31(12): 2484-2498, 2011.
  8. Krymskaya VP, Snow J, Cesarone G, Khavin I, Goncharov DA, Lim PN, Veasey SC, Ihida-Stansbury K, Jones PL,Goncharova EA: mTOR is Required for Pulmonary Arterial Vascular Smooth Muscle Cell Proliferation Under Chronic Hypoxia. The FASEB Journal 25(6): 1922-1933, 2011.
  9. Goncharova EA, Lim PN, Chisolm A, Fogle H.W. III, Taylor, J.H., Goncharov, D.A., Eszterhas, A., Panettieri, R.A., Jr., Krymskaya, V.P. : Interferons Modulate Mitogen-Induced Protein Synthesis in Airway Smooth Muscle (ASM) American Journal of Physiology - Lung Cellular and Molecular Physiology 299: L25-L35, 2010.
  10. Goncharova EA, Goncharov DA, Damera G, Tliba O, Amrani Y, Panettieri RA, Krymskaya VP: STAT3 is required for abnormal proliferation and survival of TSC2-deficient cells: relevance to pulmonary LAM.Molecular Pharmacology 76(4): 766-777, 2009.
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