Laboratory of Rare Lung Diseases

Joseph Jude, B.V.Sc., Ph.D.

Postdoctoral Fellow
University of Pennsylvania Medical Center
Pulmonary, Allergy, & Critical Care Division
Translational Research Laboratories (TRL)
125 South 31st Street, TRL Suite 1200
Philadelphia, PA 19104-3413

(215) 746-2893
 (215) 746-1224
aantony@mail.med.upenn.edu

Education: 
Ph.D., University of Minnesota, St. Paul, MN
B.V.Sc., University of Peradeniya, Sri Lanka

Postdoctoral Fellowship:
University of Minnesota, St Paul, MN

Airway smooth muscle (ASM) cells contribute to asthma pathology through their synthetic and mechanical (contractile) functions. Joseph is interested in the molecular and cellular signaling mechanisms of ASM cells in airway disorders such as asthma. His current research focus is on the mechanisms of airway hypersensitivity exacerbation by environmental pollutants like ozone. Ozone and other environmental pollutants are associated exacerbation of clinical signs in asthmatic patients.

Selected publications

  1. Balenga NA, Klichinsky M, Xie Z, Chan EC, Zhao M, Jude J, Laviolette M, Panettieri RA Jr, Druey KM. A fungal protease allergen provokes airway hyper-responsiveness in asthma. Nat Commun. 2015 Apr 13;6:6763. 
  2. Guedes AG, Jude JA, Paulin J, Rivero-Nava L, Kita H, Lund FE, Kannan MS. Airway responsiveness in CD38-deficient mice in allergic airway disease: studies with bone marrow chimeras. Am J Physiol Lung Cell Mol Physiol. 2015 Mar 1;308(5):L485-93.
  3. Dileepan M, Jude JA, Rao SP, Walseth TF, Panettieri RA, Subramanian S, Kannan MS. MicroRNA-708 regulates CD38 expression through signaling pathways JNK MAP kinase and PTEN/AKT in human airway smooth muscle cells. Respir Res. 2014 Aug 31; 15(1):107. [Epub ahead of print]
  4. Jude JA, Dileepan M, Panettieri RA Jr, Walseth TF, Kannan MS. Altered CD38/Cyclic ADP-Ribose Signaling Contributes to the Asthmatic Phenotype. J Allergy (Cairo). 2012;2012:289468. Epub 2012 Nov 20.
  5. Joseph A. Jude, Mythili Dileepan, Subbaya Subramanian, Julian Solway, Reynold A. Panettieri, Timothy F.Walseth, Mathur S. Kannan. MiR-140-3p regulation of TNF-alpha-induced CD38 expression in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2012 Sep; 303(5):L460-468.
  6. Joseph A. Jude, Krishnaswamy G. Tirumurugaan, Bit Na Kang. Reynold A. Panettieri, Timothy F. Walseth, Mathur S. Kannan. Regulation of CD38 Expression in Human Airway Smooth Muscle Cells: Role of Class I Phosphatidylinositol 3 Kinases. Am J Respir Cell Mol. Biol. 2012 May 3 (Epub ahead of print).
  7. Joseph A. Jude, Reynold A. Panettieri Jr, Timothy F. Walseth and Mathur S. Kannan. TNF-alpha regulation of CD38 expression in human airway smooth muscle: Role of MAPK Kinases and NF-kB. Adv Exp Med Biol 2011. 691: 449-459.
  8. Joseph A. Jude, Julian Solway, Reynold A. Panettieri, Timothy F. Walseth, Mathur S. Kannan. Differential induction of CD38 expression by TNF-alpha in asthmatic airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2010, 299 (6): L879-890.
  9. Bit Na Kang, Joseph A. Jude*, Reynold A. Panettieri Jr, Timothy F. Walseth, Mathur S. Kannan.Glucocorticoid regulation of CD38 expression in human airway smooth muscle cells: Role of dual specificity phosphatase I. Am J Physiol Lung Cell Mol Physiol. 2008 Jul; 295(1):L186-93 (*Co-first author)
  10. Alonso G.P. Guedes, Joseph A. Jude, Jaime Paulin, Hirohito Kita, Frances E. Lund, Mathur S. Kannan. Role of CD38 in TNF-alpha-induced airway hyperresponsiveness. Am J Physiol Lung Cell Mol Physiol. 2008 Feb; 294(2):L290-9.
Top