Laboratory of Rare Lung Diseases

Zhilong Jiang, Ph.D.

Zhilong JiangResearch Specialist C
University of Pennsylvania Medical Center
Pulmonary, Allergy, & Critical Care Division
Translational Research Laboratories (TRL)
125 South 31st Street, TRL Suite 1200
Philadelphia, PA 19104-3413

(215) 746-3598
(215) 746-1224
jiangz@mail.med.upenn.edu

Education: 
PhD, Molecular Biology, Shanghai Second Medical University

Postdoctoral Fellowship: 
University of Pittsburgh, Pittsburgh, PA  

Dr. Jiang joined the Airways Biology Initiative (ABI) in 2011 as a postdoctoral fellow in Dr. Haczku's laboratory. Dr. Jiang's current research interests are in the role of PAF-AH/Lp-PLA2 and anaphylactic response to allergic sensitization. He observed an important role of LP-PLA2 in prevention of immune response skewing towards Th2-type during the allergic sensitization process, but LP-PLA2 deficiency did not significantly change lung resistance and dynamic compliance in LP-PLA2-/- mice. Further investigation of underlying immunological mechanisms is under way. In addition, he has developed a protocol for isolation and culture of primary human type II epithelial cells (hAECII), signal transduction mechanisms of dexamethasone and pro-inflammatory cytokines on lung collectins (SP-A and SP-D) expression in hAECII cells is under investigation.

Selected publications

  1. Jiang Z, Fehrenbach M, Ravaioli G, Ducka B, Redai IG, Sheardown SA, Wilson S, Macphee C, Haczku A. The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in aspergillus fumigatus sensitized mice. Respir Res. 2012 Nov 12; 13(1):100. [Epub ahead of print]
  2. Jiang Z, Li H, Fitzgerald DC, Zhang GX, Rostami A. MOG(35-55) i.v suppresses experimental autoimmune encephalomyelitis partially through modulation of Th17 and JAK/STAT pathways. Eur J Immunol. 2009, 39(3):789-99.
  3. Yang J, Jiang Z, Fitzgerald DC, Ma C, Yu S, Li H, Zhao Z, Li Y, Ciric B, Curtis M, Rostami A, Zhang GX. Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis. J Clin Invest. 2009, 119:3678-91.
  4. Jiang Z, Guan Y, Ciric B, Rostami AM, Zhang GX. Upregulation of chemokine receptor expression by IL-10/IL-4 in adult neural stem cells. Exp Mol Pathol. 2008, 85:232-6.
  5. Jiang Z, Clemens, P.R.Cellular caspase-8-like inhibitory protein (cFLIP) prevents inhibition of muscle cell differentiation induced by cancer cells. FASEB J.2006; 20: E1979-1989.
  6. Jiang Z, Schiedner, G., Rooijen, N. V., Liu C. C., Kochanek, S., Clemens, P.R. Sustained muscle expression of dystrophin from a high-capacity adenoviral vector with systemic gene transfer of T cell costimulatory blockade. Molecular Therapy 2004; 10: 688-696.
  7. Jiang Z, Schiedner, G., Gilchrist, S. C., Kochanek, S., Clemens, P. R. CTLA4Ig delivered by high-capacity adenoviral vector induces stable expression of dystrophin in mdx mouse muscle. Gene Therapy 2004; 11:1453-1461.
  8. Jiang Z, Feingold, E., Kochanek, S., Clemens, P.R. Systemic delivery of a high-capacity adenoviral vector expressing mCTLA4Ig improves skeletal muscle gene therapy. Molecular Therapy. 2002; 6: 369-376.
  9. Jiang Z, Reay, D., Kreppel, F., Gambotto, A., Feingold, E., Kochanek, S., McCarthy, S.A., Clemens, P.R. Local high-capacity adenovirus-mediated mCTLA4Ig and mCD40Ig expression prolongs recombinant gene expression in skeletal muscle. Molecular Therapy. 2001; 3: 892-900.
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