Ongoing Efforts in Cardiac Arrest Research
The study of cardiac arrest mechanisms, pathobiology, and management are central to the mission of the Center for Resuscitation Science and have formed the backbone of our research since our founding in 2006. We currently have active studies that span the range of research, from studies of biomarkers to clinical trials in post-cardiac arrest care.
Principal Investigator: Benjamin Abella, MD MPhil
Contact: benjamin.abella@pennmedicine.upenn.edu
Dr. Abella studies sudden cardiac arrest, a leading cause of death that claims over 350,000 lives each year in the United States. Specifically, projects within his clinical research team include: (1) evaluation of CPR and resuscitation performance, (2) testing new methods to teach CPR in the community, (3) prognostication of neurologic outcomes after cardiac arrest, and (4) methods to improve post-arrest care and outcomes. Dr. Abella is also the developer and Medical Director of a novel training course for post-arrest care and targeted temperature management (TTM), the Penn TTM Academy.
Dr. Abella has published over 250 scholarly works, reviews and monographs in numerous professional journals including NEJM, JAMA and Circulation, as well as textbook chapters on cardiac arrest and resuscitation. He is Co-Chair of the global Resuscitation Science Symposium and has participated in developing international CPR guidelines. He has won a number of honors for his research, clinical care in the Emergency Department and his teaching of residents and medical students and has lectured widely on the topics of cardiac arrest and post-arrest treatment. The investigative work of Dr. Abella’s team is supported by funding from the NIH and PCORI, as well as industry sources.
Dr. Abella can be found on Twitter @benjaminabella
Benjamin Abella's Recent Publications
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The Recovery of Consciousness via Evidence-Based Medicine and Research (RECOVER) Program: A Paradigm for Advancing Neuroprognostication.
Neurology. Clinical practice. 2024 Dec;14(6):e200351 Epub 2024 Aug 16; Authors: Fischer D, Abella BS, Bass GD, Charles J, Hampton S, Kulick-Soper CV, Mendlik MT, Mitchell OJ, Narva AM, Pino W, Sikandar ML, Sinha SR, Waldman GJ, Ware JB, Levine JM -
Anaerobic Lactate Production Is Associated With Decreased Microcirculatory Blood Flow and Decreased Mitochondrial Respiration Following Cardiovascular Surgery With Cardiopulmonary Bypass.
Critical care medicine. 2024 Aug 1;52(8):1239-1250 Epub 2024 Apr 5; Authors: Greenwood JC, Talebi FM, Jang DH, Spelde AE, Gordon EK, Horak J, Acker MA, Kilbaugh TJ, Shofer FS, Augoustides JGT, Brenner JS, Muzykantov VR, Bakker J, Abella BS -
Real-time performance improvement optimizes damage control resuscitation best practice adherence: Results of a pilot prospective observational study.
Transfusion. 2024 Jul 27; Authors: Schmulevich D, Geng Z, Joergensen SM, McLauchlan NR, Winter E, Zone A, Bishop KE, Hinkle A, Holland S, Cacchione PZ, Fox EE, Abella BS, Meador CL, Wade CE, Hynes AM, Cannon JW -
A Systematic Literature Review to Assess Fever Management and the Quality of Targeted Temperature Management in Critically Ill Patients.
Therapeutic hypothermia and temperature management. 2024 Jun;14(2):68-79 Epub 2023 May 22; Authors: Miao B, Skaar JR, O'Hara M, Post A, Kelly T, Abella BS -
Carbon monoxide as a cellular protective agent in a swine model of cardiac arrest protocol.
PloS one. 2024;19(5):e0302653 Epub 2024 May 15; Authors: Greenwood JC, Morgan RW, Abella BS, Shofer FS, Baker WB, Lewis A, Ko TS, Forti RM, Yodh AG, Kao SH, Shin SS, Kilbaugh TJ, Jang DH -
The Association of Racial Residential Segregation and Survival After Out-of-Hospital Cardiac Arrest in the United States.
medRxiv : the preprint server for health sciences. 2024 Apr 22; Authors: Abbott EE, Buckler DG, Shekhar AC, Landry E, Abella BS, Richardson LD, Zebrowski AM, CARES Surveillance Group -
Machine learning model to predict evolution of pulseless electrical activity during in-hospital cardiac arrest.
Resuscitation plus. 2024 Mar;17:100598 Epub 2024 Mar 8; Authors: Urteaga J, Elola A, Norvik A, Unneland E, Eftestøl TC, Bhardwaj A, Buckler D, Abella BS, Skogvoll E, Aramendi E -
Using generative artificial intelligence in bibliometric analysis: 10 years of research trends from the European Resuscitation Congresses.
Resuscitation plus. 2024 Jun;18:100584 Epub 2024 Feb 22; Authors: Fijačko N, Creber RM, Abella BS, Kocbek P, Metličar Š, Greif R, Štiglic G -
Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials.
Nature communications. 2024 Feb 5;15(1):1075; Authors: Axfors C, Schmitt AM, Janiaud P, Van't Hooft J, Abd-Elsalam S, Abdo EF, Abella BS, Akram J, Amaravadi RK, Angus DC, Arabi YM, Azhar S, Baden LR, Baker AW, Belkhir L, Benfield T, Berrevoets MAH, Chen CP, Chen TC, Cheng SH, Cheng CY, Chung WS, Cohen YZ, Cowan LN, Dalgard O, de Almeida E Val FF, de Lacerda MVG, de Melo GC, Derde L, Dubee V, Elfakir A, Gordon AC, Hernandez-Cardenas CM, Hills T, Hoepelman AIM, Huang YW, Igau B, Jin R, Jurado-Camacho F, Khan KS, Kremsner PG, Kreuels B, Kuo CY, Le T, Lin YC, Lin WP, Lin TH, Lyngbakken MN, McArthur C, McVerry BJ, Meza-Meneses P, Monteiro WM, Morpeth SC, Mourad A, Mulligan MJ, Murthy S, Naggie S, Narayanasamy S, Nichol A, Novack LA, O'Brien SM, Okeke NL, Perez L, Perez-Padilla R, Perrin L, Remigio-Luna A, Rivera-Martinez NE, Rockhold FW, Rodriguez-Llamazares S, Rolfe R, Rosa R, Røsjø H, Sampaio VS, Seto TB, Shahzad M, Soliman S, Stout JE, Thirion-Romero I, Troxel AB, Tseng TY, Turner NA, Ulrich RJ, Walsh SR, Webb SA, Weehuizen JM, Velinova M, Wong HL, Wrenn R, Zampieri FG, Zhong W, Moher D, Goodman SN, Ioannidis JPA, Hemkens LG -
Resuscitative transesophageal echocardiography in emergency departments in the United States and Canada: A cross-sectional survey.
The American journal of emergency medicine. 2024 Feb;76:164-172 Epub 2023 Nov 29; Authors: Teran F, West FM, Jelic T, Taylor L, Jafry ZM, Burns KM, Owyang CG, Emt CC, Abella BS, Andrus P, On behalf ACEP Emergency Ultrasound Section and the Resuscitative TEE Collaborative Registry (rTEECoRe) Investigators