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Amber was a research specialist in the lab from September 2013 to August 2015 and February 2018 to March 2021. She graduated from Stanford University with a degree in Biology. She worked at a free clinic during her time there, and is interested in the health care of underserved communities. Amber was born in Houston, but has moved around and lived in different parts of the world.

Publications

Mack, K.L.*, H. Kim*, M.E. Jackrel, J. Lin, J.E. DeNizio, X. Yan, E. Chuang, A. Tariq, R.R. Cupo, L.M. Castellano, K.A. Caldwell, G.A. Caldwell, and J. Shorter. (2020). Tuning Hsp104 specificity to selectively detoxify α-synuclein. BioRxiv. doi: 10.1101/2020.04.15.043935. pdf file link (*Co-first author.).

Sweeny, E.A.^, A. Tariq, E. Gurpinar, M.S. Go, M.A. Sochor, Z.Y. Kan, L. Mayne, S.W. Englander, and J. Shorter^. (2020). Structural and mechanistic insights into Hsp104 function revealed by synchrotron x-ray footprinting. J. Biol. Chem. 295(6):1517–1538. pdf file link (^Co-corresponding author).

Tariq, A.*, J. Lin*, M.E. Jackrel*, C.D. Hesketh, P.J. Carman, K.L. Mack, R. Weitzman, C. Gambogi, O.A. Hernandez Murillo, E.A. Sweeny, E. Gurpinar, A.L. Yokom, S.N. Gates, K. Yee, S. Sudesh, J. Stillman, A.N. Rizo, D.R. Southworth, and J. Shorter. (2019). Mining disaggregase sequence space to safely counter TDP-43, FUS, and alpha-synuclein proteotoxicity. Cell Rep. 28(8):2080–2095. pdf file link (*Co-first author).

Tariq, A.*, J. Lin*, M.M. Noll*, M.P. Torrente, K.L. Mack, O. Hernandez Murillo, M.E. Jackrel, and J. Shorter. (2018). Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain. FEMS Yeast Res. doi: 10.1093/femsyr/foy042. pdf file link (*Co-first author).

Jackrel, M.E., K. Yee, A. Tariq, A.I. Chen, and J. Shorter. (2015). Disparate mutations confer therapeutic gain of Hsp104 function. ACS Chem. Biol. 10(12):2672-9. pdf file link

Jackrel, M.E., A. Tariq, K. Yee, R. Weitzman, and J. Shorter. (2014). Isolating potentiated Hsp104 variants using yeast proteinopathy models. J. Vis. Exp. 93:e52089 doi:10.3791/52089. pdf file link

 

 

People



Department of Biochemistry & Biophysics
p3
University of Pennsylvania