Mariana Torrente was a post-doctoral researcher in the lab from October 2012 to August 2015. She received dual bachelor’s degrees in Chemistry and Biochemistry from the Florida Institute of Technology in 2005 and her Ph.D. in Chemistry in 2010 from Princeton University where she comprehensively cataloged chromatin proteins -particularly histones- during biologically significant processes using high-end mass spectrometry proteomics. Prior to joining us as a PENN-PORT fellow, she was a NIH NRSA fellow at the Penn State University College of Medicine. In 2015, Mariana won a NINDS Advanced Postdoctoral Career Transition Award to Promote Diversity in Neuroscience Research (K22). Mariana went on to establish her own research program as an Assistant Professor in the Chemistry Department at Brooklyn College.


Zhu, G.*, D.S. Harischandra*, S. Ghaisas, P. Zhang, W. Prall, L. Huang, C. Maghames, L. Guo, E. Luna, K.L. Mack, M.P. Torrente, K.C. Luk, J. Shorter, and X. Yang. (2020). TRIM11 prevents and reverses protein aggregation and rescues a mouse model of Parkinson’s disease. Cell Rep. 33(9):108418. pdf file link (*Co-first author).

Tariq, A.*, J. Lin*, M.M. Noll*, M.P. Torrente, K.L. Mack, O. Hernandez Murillo, M.E. Jackrel, and J. Shorter. (2018). Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain. FEMS Yeast Res. doi: 10.1093/femsyr/foy042. pdf file link (*Co-first author).

Gates, S.N*., A.L. Yokom*, J. Lin, M.E. Jackrel, A.N. Rizo, N.M. Kendsersky, C.E. Buell, E.A. Sweeny, K.L. Mack, E. Chuang, M.P. Torrente, M. Su, J. Shorter, and D.R. Southworth. (2017). Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104. Science. 357(6348):273-279. pdf file link (*Co-first author).

Torrente, M.P., E. Chuang, M.M. Noll, M.E. Jackrel, M.S. Go, and J. Shorter. (2016). Mechanistic insights into Hsp104 potentiation. J. Biol. Chem. 291(10):5101-5115. pdf file link

Torrente, M.P., L.M. Castellano, and J. Shorter. Suramin inhibits Hsp104 ATPase and disaggregase activity. PLoS ONE. 9(10): e110115. (2014). pdf file link

Torrente, M.P., and J. Shorter. The metazoan protein disaggregase and amyloid depolymerase system: Hsp110, Hsp70, Hsp40, and small heat shock proteins. Prion. 7(6): 457-463. (2013). pdf file link

Ouedraogo, Y.P., Huang, L., Torrente, M.P., Proni, G., Chadwick, E., Wehmschulte, R.J., and Nesnas, N. A direct stereoselective preparation of a fish pheromone and application of the zinc porphyrin tweezer chiroptical protocol in its stereochemical assignment. Chirality. 25(9):575-81. (2013). pdf file link

Torrente, M.P, Freeman, W.M., and Vrana, K.V. Protein Biomarkers of Alcohol Abuse. Expert Reviews in Proteomics, 9(4), 425-36. (2012). pdf file link

Torrente, M.P, Gelenberg, A.J., and Vrana, K.V. Boosting serotonin in the brain: is it time to revamp the treatment of depression? J Psychopharmacol. 26(5), 629-35. (2012). pdf file link

Baliban, R.C., Dimaggio, P.A., Plazas-Mayorca, M.D., Garcia, B.A., Floudas, C.A. PILOT_PROTEIN: identification of unmodified and modified proteins via high-resolution mass spectrometry and mixed-integer linear optimization. J Proteome Res. 11(9), 4615-29. (2012). pdf file link

Torrente, M.P., Zee, B.M.; Young, N.L.; Baliban, R.C; Leroy, G.; Floudas, C.A.; Hake, S.B.; Garcia B.A., Proteomic Interrogation of Human Chromatin. PLoS One, 6, (9), e24747. (2011). pdf file link

Plazas-Mayorca, M.D. and Vrana, K.E. Proteomic investigation of epigenetics in neuropsychiatric disorders: A missing link between genetics and behavior? Journal of Proteome Research, 10 (1), 58–65. (2011). pdf file link

Plazas-Mayorca, M.D., Bloom, J.S., Zeissler, U., LeRoy, G., Young, N.L., DiMaggio, P.A., Krugylak, L., Schneider, R. and  Garcia, B.A. Quantitative Proteomics Reveals Direct and Indirect Alterations in the Histone Code Following Methyltransferase Knockdown. Molecular BioSystems, (6), 1719-1729. (2010). pdf file link

Baliban, R. C.; DiMaggio, P. A.; Plazas-Mayorca, M.D.; Young, N. L.; Garcia, B. A.; Floudas, C. A.,  A novel approach for untargeted post-translational modification identification using integer linear optimization and tandem mass spectrometry. Molecular & Cellular Proteomics, 9, (5), 764-79. (2010). pdf file link

Young, N.L.*; Plazas-Mayorca, M.D.*; Flaniken, I.Z.; DiMaggio, P. A.; Beltran, A.; Mishra, N.; LeRoy, G.; Floudas, C. A.; Garcia, B.A., Collective mass spectrometry approaches reveal broad and combinatorial modification of high mobility group protein A1a.. Journal of the American Society for Mass Spectrometry, 21, (6), 960-70 (2010). *These authors contributed equally to this work. pdf file link

Young, N.L.; Plazas-Mayorca, M.D.; Garcia, B.A.  Systems-wide proteomic characterization of combinatorial post-translational modification patterns.  Expert Reviews in Proteomics, 7, (1), 79. (2010) . link

Plazas-Mayorca, M.D.; Zee, B.M.; Young, N.L.; Fingerman, I.M.; LeRoy, G.; Briggs, S.D.; Garcia B.A., One-pot shotgun quantitative mass spectrometry characterization of histones.  Journal of Proteome Research, 8, (11), 5367-74. (2009). pdf file link

Young, N. L.; DiMaggio, P. A.; Plazas-Mayorca, M. D.; Baliban, R. C.; Floudas, C. A.; Garcia, B. A., High-throughput characterization of combinatorial histone codes. Molecular & Cellular Proteomics, 8, (10), 2266-84. (2009). pdf file link

Leroy, G.; Weston, J. T.; Zee, B. M.; Young, N. L.; Plazas-Mayorca, M. D.; Garcia, B. A., Heterochromatin protein 1 is extensively decorated with histone code-like post-translational modifications. Molecular & Cellular Proteomics, 8, (11), 2432-42. (2009). pdf file link







Department of Biochemistry & Biophysics
University of Pennsylvania